HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: IL5RA (Q01344)
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
Gene: IL5RA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 420
+	Hs
		689941 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		IL3RA_HUMAN (26-409): 1.51e-61: 205: 24.06
+	Hs
		728673 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		IL2RG_HUMAN (80-400): 8.95e-48: 168: 17.26
+	Hs
		533840 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		GHR_HUMAN (106-398): 9.51e-43: 160: 17.54
+	Mm
		575630 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		EPOR_MOUSE (97-392): 7.51e-41: 153: 17.26
+	Hs
		619214 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPOR_HUMAN (113-391): 7.75e-35: 136: 18.54
+	Hs
		619220 GRAP_HUMAN (1-213): 8.58e-61: 191: 56.74		EPOR_HUMAN (113-391): 7.75e-35: 136: 18.54
+	Hs
		987884 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CSF3R_HUMAN (123-339): 1.08e-18: 90.7: 15.58
+	Mm
		821233 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		CSF3R_MOUSE (121-339): 2.04e-16: 83.7: 16.17
+	Hs
		932053 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPHA4_HUMAN (29-239): 3.91e-16: 82.6: 10.39
+	Hs
		599187 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		IL7RA_HUMAN (211-385): 2.37e-15: 79.5: 13.54
+	Mm
		932044 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		EPHB2_MOUSE (25-238): 4.37e-14: 76.4: 11.11
+	Hs
		710698 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPHA8_HUMAN (29-239): 3.62e-14: 76.8: 11.40
+	Hs
		710805 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPHB2_HUMAN (25-238): 4.48e-14: 76.4: 11.11
+	Hs
		710618 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPHA3_HUMAN (29-256): 1.58e-12: 71.4: 13.25
+	Hs
		871470 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		LEPR_HUMAN (38-387): 4.82e-12: 70.2: 15.12
+	Hs
		932029 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		EPHB1_HUMAN (23-237): 3.53e-11: 67.2: 9.79
+	Hs
		820526 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		IL6RB_HUMAN (12-340): 1.38e-10: 65.3: 9.86
+	Hs
		533825 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		GHR_HUMAN (106-398): 9.51e-43: 160: 17.54
+	Mm
		440273 LCK_MOUSE (3-202): 5.91e-38: 139: 28.44		CSF3R_MOUSE (121-339): 2.04e-16: 83.7: 16.17
+	Hs
		439918 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRF_HUMAN (13-274): 3.77e-18: 89.1: 12.03