HitPredict

Interactor 1: APLP2 (Q06481)
Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)
Gene: APLP2

Interactor 2: KLK15 (Q9H2R5)
Kallikrein-15 (EC 3.4.21.-) (ACO protease)
Gene: KLK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Kunitz_BPTI~Trypsin
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 256
+	Hs
		589596 APLP2_HUMAN (26-763): 0: 992: 100.00		KLK2_HUMAN (1-256): 2.8e-108: 314: 39.63
+	Rn
		341604 A4_RAT (42-762): 0: 832: 49.22		TRY2_RAT (1-256): 6.72e-123: 351: 42.25
+	Hs
		395374 A4_HUMAN (42-762): 0: 820: 49.09		KLK6_HUMAN (1-255): 1.16e-108: 315: 43.14
+	Hs
		394096 A4_HUMAN (42-762): 0: 820: 49.09		KLK2_HUMAN (1-256): 2.8e-108: 314: 39.63
+	Hs
		371454 A4_HUMAN (42-762): 0: 820: 49.09		FA11_HUMAN (5-255): 3.36e-97: 298: 30.08
+	Hs
		394348 A4_HUMAN (42-762): 0: 820: 49.09		KLK7_HUMAN (13-255): 1.69e-101: 297: 41.98
+	Hs
		396025 A4_HUMAN (42-762): 0: 820: 49.09		KLK9_HUMAN (19-255): 1.14e-98: 290: 46.89
+	Hs
		395252 A4_HUMAN (42-762): 0: 820: 49.09		PRS33_HUMAN (10-250): 1.67e-95: 283: 32.18
+	Hs
		395060 A4_HUMAN (42-762): 0: 820: 49.09		TM11B_HUMAN (12-252): 2.35e-92: 279: 33.33
+	Hs
		199478 SPIT1_HUMAN (282-405): 1.24e-20: 98.4: 21.60		KLK15_HUMAN (1-256): 3.74e-114: 329: 100.00
+	Bt
		341601 BPT1_BOVIN (288-366): 2.29e-21: 91.1: 36.71		TRY1_BOVIN (1-256): 4.58e-117: 336: 43.41
+	Hs
		498395 TFPI1_HUMAN (287-405): 2.87e-18: 88: 19.73		TRY3_HUMAN (8-256): 1.1e-114: 332: 41.37
+	Hs
		199968 SPIT2_HUMAN (305-423): 9.2e-20: 91.5: 18.94		KLK11_HUMAN (19-256): 3.18e-107: 312: 50.41
+	Hs
		199896 SPIT2_HUMAN (305-423): 9.2e-20: 91.5: 18.94		PRSS8_HUMAN (10-253): 4.37e-98: 292: 33.46
+	Hs
		199447 SPIT1_HUMAN (282-405): 1.24e-20: 98.4: 21.60		GRAH_HUMAN (14-255): 1.82e-48: 162: 37.10