HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PTPR2 (Q92932)
Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
Gene: PTPRN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1015
+	Hs
		440050 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTN13_HUMAN (90-1015): 3.07e-152: 502: 17.72
+	Hs
		440088 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTN14_HUMAN (95-1007): 5.85e-150: 478: 15.75
+	Hs
		711089 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTN6_HUMAN (740-1014): 6.09e-118: 376: 37.98
+	Hs
		440094 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRO_HUMAN (165-1011): 3.83e-144: 463: 16.25
+	Mm
		611452 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		PTPRA_MOUSE (729-1006): 1.93e-106: 352: 36.20
+	Hs
		614675 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTPRA_HUMAN (729-1006): 2.96e-105: 348: 36.20
+	Hs
		658960 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTPRE_HUMAN (741-1006): 7.89e-97: 323: 36.16
+	Hs
		439966 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTN6_HUMAN (740-1014): 6.09e-118: 376: 37.98
+	Mm
		449217 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		PTPRC_MOUSE (735-1013): 5.08e-65: 241: 28.34
+	Hs
		439918 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRF_HUMAN (740-1006): 5.34e-91: 321: 34.94
+	Hs
		155413 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTPRT_HUMAN (737-1008): 1.82e-60: 228: 32.14
+	Hs
		987595 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTPRJ_HUMAN (763-997): 1.07e-43: 175: 41.60
+	Mm
		440267 LCK_MOUSE (3-202): 5.91e-38: 139: 28.44		PTPRC_MOUSE (735-1013): 5.08e-65: 241: 28.34
+	Hs
		439951 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRG_HUMAN (123-1011): 1.81e-63: 237: 15.14
+	Hs
		439963 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRM_HUMAN (735-1009): 4.1e-60: 227: 31.10
+	Hs
		440082 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRK_HUMAN (734-1008): 2.68e-57: 218: 31.10
+	Hs
		658997 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		PTPRG_HUMAN (123-1011): 1.81e-63: 237: 15.14
+	Hs
		439952 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRZ_HUMAN (708-1014): 1.51e-51: 200: 22.79
+	Hs
		440049 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRJ_HUMAN (763-997): 1.07e-43: 175: 41.60
+	Hs
		659075 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		PTPRZ_HUMAN (708-1014): 1.51e-51: 200: 22.79