Protein: GLYC
Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Gene: GLYC, SHMT1
Organism: Homo sapiens
Interactions: 64
UniProt ID: P34896

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

760816

GLYC
Serine hydroxymethyltransferase, cytosolic

3

5

High-throughput

0.861

High

760817

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

5

High-throughput

0.811

High

760820

MK09
Mitogen-activated protein kinase 9

4

1

High-throughput

0.698

High

693248

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

1

High-throughput

0.628

High

760830

ABRX2
BRISC complex subunit Abraxas 2

1

1

Small-scale

0.618

High

684095

DDX6
Probable ATP-dependent RNA helicase DDX6

2

3

High-throughput

0.606

High

760831

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

760844

DPYL5
Dihydropyrimidinase-related protein 5

2

0

High-throughput

0.602

High

240890

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

760843

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

760854

FBX2
F-box only protein 2

2

0

High-throughput

0.576

High

516056

ST1A4
Sulfotransferase 1A4

1

0

High-throughput

0.549

High

540988

PIM1
Serine/threonine-protein kinase pim-1

1

1

High-throughput

0.541

High

760826

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

760838

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

760850

DOCK5
Dedicator of cytokinesis protein 5

1

1

High-throughput

0.536

High

326238

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

256586

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.513

High

549541

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

760823

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.513

High

760824

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

760825

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

760857

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

67625

RHG32
Rho GTPase-activating protein 32

1

1

High-throughput

0.479

High

258780

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

529201

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

588030

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

623142

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

694744

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

760818

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

760819

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

760821

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

Small-scale

0.479

High

760822

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

760827

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

760828

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

760837

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

760839

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

760840

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

760841

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

760848

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

760853

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

289071

DEDD
Death effector domain-containing protein

1

0

High-throughput

0.460

High

227400

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

255389

SNX2
Sorting nexin-2

1

0

High-throughput

0.458

High

760835

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

760845

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.458

High

760847

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

760849

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

429389

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

760832

FAXC
Failed axon connections homolog

1

1

High-throughput

0.445

High

760834

WDR74
WD repeat-containing protein 74

1

1

High-throughput

0.445

High

760842

FRMD6
FERM domain-containing protein 6

1

1

High-throughput

0.445

High

760846

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.445

High

602871

INAR1
Interferon alpha/beta receptor 1

1

2

Small-scale

0.437

High

648439

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.437

High

760833

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

760836

NBEL2
Neurobeachin-like protein 2

1

0

High-throughput

0.426

High

760855

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.426

High

760856

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

760851

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

211677

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low

760829

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.232

Low

760852

PCD10
Protocadherin-10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025