Protein: TM129
E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129)

Gene: TM129, TMEM129
Organism: Homo sapiens
Interactions: 47
UniProt ID: A0AVI4

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006986 - response to unfolded protein

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

48253

DERL1
Derlin-1

3

1

Small-scale

0.640

High

48221

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

0

Small-scale

0.559

High

48250

RHG07
Rho GTPase-activating protein 7

1

0

High-throughput

0.518

High

48225

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

48229

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

1

Small-scale

0.501

High

48234

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

Small-scale

0.501

High

48219

WFS1
Wolframin

1

0

High-throughput

0.493

High

48222

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

48216

TM129
E3 ubiquitin-protein ligase TM129

1

0

Small-scale

0.480

High

48243

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

48244

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

2

Small-scale

0.479

High

48255

DERL2
Derlin-2

1

1

Small-scale

0.479

High

48228

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.458

High

48232

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

48235

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

48236

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.458

High

48245

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.458

High

48249

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.458

High

48251

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

48252

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

48257

SE1L1
Protein sel-1 homolog 1

1

0

Small-scale

0.458

High

48261

HYOU1
Hypoxia up-regulated protein 1

1

0

High-throughput

0.458

High

48259

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.445

High

48233

FCGRN
IgG receptor FcRn large subunit p51

1

1

Small-scale

0.437

High

48226

ECE1
Endothelin-converting enzyme 1

1

0

High-throughput

0.426

High

48238

UBE4A
Ubiquitin conjugation factor E4 A

1

0

High-throughput

0.426

High

48242

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.426

High

48246

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.426

High

48258

UBQL2
Ubiquilin-2

1

0

High-throughput

0.426

High

48239

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.282

High

48248

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.282

High

48220

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

48231

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.261

Low

48217

CPNE3
Copine-3

1

0

High-throughput

0.249

Low

48218

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.249

Low

48227

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

48254

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.249

Low

48256

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

48260

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.249

Low

48223

INHA
Inhibin alpha chain

1

0

High-throughput

0.232

Low

48224

DCUP
Uroporphyrinogen decarboxylase

1

0

High-throughput

0.232

Low

48230

IST1
IST1 homolog

1

0

High-throughput

0.232

Low

48237

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

High-throughput

0.232

Low

48240

S6A19
Sodium-dependent neutral amino acid transporter B(0)AT1

1

0

High-throughput

0.232

Low

48241

UN13D
Protein unc-13 homolog D

1

0

High-throughput

0.232

Low

48247

DMXL2
DmX-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025