Protein: DIRA2
GTP-binding protein Di-Ras2 (EC 3.6.5.-) (Distinct subgroup of the Ras family member 2)

Gene: DIRA2, DIRAS2
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q96HU8

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0019003 - GDP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

911859

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

5

12

High-throughput

0.826

High

164824

UN13B
Protein unc-13 homolog B

2

5

High-throughput

0.811

High

1393560

SIRPD
Signal-regulatory protein delta

2

0

High-throughput

0.770

High

1393561

UN45A
Protein unc-45 homolog A

2

2

High-throughput

0.700

High

325402

DIRA1
GTP-binding protein Di-Ras1

1

19

High-throughput

0.691

High

401301

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

822816

VHL
von Hippel-Lindau disease tumor suppressor

1

5

Small-scale

0.618

High

1324042

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.618

High

1393563

ZN581
Zinc finger protein 581

2

1

High-throughput

0.574

High

626331

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

High-throughput

0.514

High

443922

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

7

Small-scale

0.479

High

461810

HS90A
Heat shock protein HSP 90-alpha

1

8

Small-scale

0.479

High

468689

HS90B
Heat shock protein HSP 90-beta

1

8

Small-scale

0.479

High

535410

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

537707

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

947251

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

High-throughput

0.479

High

997464

TBB4B
Tubulin beta-4B chain

1

3

Small-scale

0.479

High

1024763

VIGLN
Vigilin

1

6

High-throughput

0.479

High

1393558

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

1393565

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.479

High

227641

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.437

High

242584

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.437

High

323526

TRI37
E3 ubiquitin-protein ligase TRIM37

1

19

High-throughput

0.437

High

385316

K2C6A
Keratin, type II cytoskeletal 6A

1

2

Small-scale

0.437

High

407510

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.437

High

476376

K1C16
Keratin, type I cytoskeletal 16

1

3

Small-scale

0.437

High

566201

K1C10
Keratin, type I cytoskeletal 10

1

3

Small-scale

0.437

High

573206

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.437

High

772048

K1C9
Keratin, type I cytoskeletal 9

1

3

Small-scale

0.437

High

777538

K22E
Keratin, type II cytoskeletal 2 epidermal

1

2

Small-scale

0.437

High

801465

HSPA9
Stress-70 protein, mitochondrial

1

14

Small-scale

0.437

High

1098093

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

Small-scale

0.437

High

1290109

THOC4
THO complex subunit 4

1

2

Small-scale

0.437

High

1295704

HORN
Hornerin

1

2

Small-scale

0.437

High

1393562

RNF12
E3 ubiquitin-protein ligase RLIM

1

20

High-throughput

0.437

High

1393564

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.437

High

372846

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.407

High

430239

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

843869

HD
Huntingtin

1

8

High-throughput

0.407

High

935001

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.407

High

1393559

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.328

High

1068922

RIPP1
Protein ripply1

2

0

High-throughput

0.316

High

1239778

FAP20
Fanconi anemia core complex-associated protein 20

1

0

High-throughput

0.279

Low

1393566

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

1103

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025