Protein: ZN581
Zinc finger protein 581

Gene: ZN581, ZNF581
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q9P0T4

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1186366

ZN792
Zinc finger protein 792

2

20

High-throughput

0.783

High

1271972

ZN765
Zinc finger protein 765

2

20

High-throughput

0.783

High

1454007

PLAL2
Zinc finger protein PLAGL2

2

18

High-throughput

0.783

High

1104688

IKZF1
DNA-binding protein Ikaros

1

20

High-throughput

0.740

High

1372111

RBPMS
RNA-binding protein with multiple splicing

5

2

High-throughput

0.728

High

783436

TRI23
E3 ubiquitin-protein ligase TRIM23

5

1

High-throughput

0.722

High

1407118

MDFI
MyoD family inhibitor

5

6

High-throughput

0.722

High

51508

FSD2
Fibronectin type III and SPRY domain-containing protein 2

3

20

High-throughput

0.675

High

572254

TRI27
Zinc finger protein RFP

3

20

High-throughput

0.675

High

1218031

MYOME
Myomegalin

3

2

High-throughput

0.675

High

1238137

HMBX1
Homeobox-containing protein 1

3

6

High-throughput

0.675

High

1348552

LNX1
E3 ubiquitin-protein ligase LNX

3

6

High-throughput

0.675

High

1414795

TRAF4
TNF receptor-associated factor 4

3

20

High-throughput

0.675

High

1157502

PKN1
Serine/threonine-protein kinase N1

1

5

High-throughput

0.665

High

1454005

ZRAN1
Ubiquitin thioesterase ZRANB1

3

10

High-throughput

0.653

High

1336491

PNMA1
Paraneoplastic antigen Ma1

4

3

High-throughput

0.646

High

1014218

CBX1
Chromobox protein homolog 1

2

20

High-throughput

0.628

High

1066252

DMWD
Dystrophia myotonica WD repeat-containing protein

2

10

High-throughput

0.628

High

1133016

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

5

High-throughput

0.628

High

1401948

ERBIN
Erbin

2

2

High-throughput

0.628

High

1432098

ADNP
Activity-dependent neuroprotector homeobox protein

2

5

High-throughput

0.628

High

1206011

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

8

High-throughput

0.628

High

1454003

ZN581
Zinc finger protein 581

1

17

High-throughput

0.621

High

950424

KR107
Keratin-associated protein 10-7

3

20

High-throughput

0.616

High

1230291

K1C40
Keratin, type I cytoskeletal 40

3

11

High-throughput

0.616

High

1332058

BANP
Protein BANP

3

1

High-throughput

0.616

High

1332446

CBY2
Protein chibby homolog 2

3

1

High-throughput

0.616

High

225711

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

2

High-throughput

0.606

High

913075

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

5

High-throughput

0.606

High

1121172

SRTD2
SERTA domain-containing protein 2

2

2

High-throughput

0.606

High

1151676

TRIP6
Thyroid receptor-interacting protein 6

2

1

High-throughput

0.606

High

1216165

FHL5
Four and a half LIM domains protein 5

2

5

High-throughput

0.606

High

1219152

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

1

High-throughput

0.606

High

1359008

TEKT4
Tektin-4

2

1

High-throughput

0.606

High

1408118

SPAG8
Sperm-associated antigen 8

2

1

High-throughput

0.606

High

1436614

PKHF2
Pleckstrin homology domain-containing family F member 2

2

5

High-throughput

0.606

High

1448901

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

2

4

High-throughput

0.606

High

1453157

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.606

High

1198922

HIKES
Protein Hikeshi

2

0

High-throughput

0.602

High

1349617

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

2

0

High-throughput

0.602

High

1397696

KS6R
Ribosomal protein S6 kinase-related protein

1

3

High-throughput

0.594

High

1410112

KR412
Keratin-associated protein 4-12

2

20

High-throughput

0.590

High

1411349

LZTS2
Leucine zipper putative tumor suppressor 2

2

12

High-throughput

0.590

High

1356691

CHUR
Protein Churchill

2

0

High-throughput

0.580

High

1370720

SMRC1
SWI/SNF complex subunit SMARCC1

2

0

High-throughput

0.580

High

1451056

FANCL
E3 ubiquitin-protein ligase FANCL

2

0

High-throughput

0.580

High

1277432

NT2NA
Notch homolog 2 N-terminal-like protein A

2

20

High-throughput

0.578

High

1393563

DIRA2
GTP-binding protein Di-Ras2

2

1

High-throughput

0.574

High

1395359

CC136
Coiled-coil domain-containing protein 136

2

7

High-throughput

0.573

High

332593

CCDB1
Cyclin-D1-binding protein 1

1

1

High-throughput

0.573

High

776137

SOX5
Transcription factor SOX-5

1

11

High-throughput

0.573

High

1093984

TRAF1
TNF receptor-associated factor 1

1

11

High-throughput

0.573

High

1095825

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.573

High

159892

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

8

High-throughput

0.560

High

1325771

LNX2
Ligand of Numb protein X 2

1

6

High-throughput

0.560

High

65178

GG6L9
Golgin subfamily A member 6-like protein 9

2

15

High-throughput

0.553

High

70517

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.553

High

269404

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.553

High

300519

KRT34
Keratin, type I cuticular Ha4

2

11

High-throughput

0.553

High

351613

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

20

High-throughput

0.553

High

948400

KR122
Keratin-associated protein 12-2

2

20

High-throughput

0.553

High

950708

KR108
Keratin-associated protein 10-8

2

20

High-throughput

0.553

High

1059754

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

1119793

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

5

High-throughput

0.553

High

1277646

K1C27
Keratin, type I cytoskeletal 27

2

4

High-throughput

0.553

High

1361065

ASB13
Ankyrin repeat and SOCS box protein 13

2

3

High-throughput

0.553

High

1371459

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

10

High-throughput

0.553

High

1386726

AP2M1
AP-2 complex subunit mu

2

1

High-throughput

0.553

High

1411586

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

1

High-throughput

0.553

High

1416378

CAR10
Caspase recruitment domain-containing protein 10

2

12

High-throughput

0.553

High

1430128

ENKD1
Enkurin domain-containing protein 1

2

2

High-throughput

0.553

High

1453216

SPG21
Maspardin

2

1

High-throughput

0.553

High

180608

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.541

High

462687

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

6

High-throughput

0.541

High

1139154

DAZP2
DAZ-associated protein 2

1

1

High-throughput

0.541

High

1380873

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.541

High

1419315

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

270119

TMCC2
Transmembrane and coiled-coil domains protein 2

2

1

High-throughput

0.526

High

685966

KRA59
Keratin-associated protein 5-9

1

20

High-throughput

0.523

High

950908

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.523

High

1063662

GOGA2
Golgin subfamily A member 2

1

16

High-throughput

0.523

High

1338522

DOCK8
Dedicator of cytokinesis protein 8

1

1

High-throughput

0.523

High

1419098

KRA42
Keratin-associated protein 4-2

1

20

High-throughput

0.523

High

1430873

SDCB2
Syntenin-2

1

8

High-throughput

0.523

High

1439574

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

4

High-throughput

0.523

High

1031963

NC2B
Protein Dr1

1

2

High-throughput

0.515

High

1096253

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.515

High

1454004

RIM3A
RIMS-binding protein 3A

1

3

High-throughput

0.515

High

246997

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.508

High

963381

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.493

High

1136400

EMC2
ER membrane protein complex subunit 2

1

4

High-throughput

0.489

High

66405

RIM3C
RIMS-binding protein 3C

1

1

High-throughput

0.481

High

216551

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.481

High

1432692

BOLA2
BolA-like protein 2

1

2

High-throughput

0.481

High

1005192

RNF4
E3 ubiquitin-protein ligase RNF4

1

17

High-throughput

0.479

High

1114502

CUL3
Cullin-3

1

20

High-throughput

0.479

High

780

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

2

High-throughput

0.470

High

109525

G5E9A7
DM1 locus, WD repeat containing

1

10

High-throughput

0.470

High

442500

GELS
Gelsolin

1

4

High-throughput

0.470

High

517126

NT2NC
Notch homolog 2 N-terminal-like protein C

1

20

High-throughput

0.470

High

570619

GFAP
Glial fibrillary acidic protein

1

9

High-throughput

0.470

High

650459

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.470

High

1119015

BYST
Bystin

1

4

High-throughput

0.470

High

1279777

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

13

High-throughput

0.470

High

1308338

Q8IV28
Nidogen-2

1

16

High-throughput

0.470

High

1360768

JPH3
Junctophilin-3

1

7

High-throughput

0.470

High

1419149

KRA24
Keratin-associated protein 2-4

1

20

High-throughput

0.470

High

1454009

TF3C3
General transcription factor 3C polypeptide 3

1

7

High-throughput

0.470

High

423360

A4
Amyloid-beta precursor protein

1

13

High-throughput

0.457

High

1454006

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

High-throughput

0.457

High

646

NBPFJ
NBPF family member NBPF19

1

5

High-throughput

0.439

High

505388

KRA23
Keratin-associated protein 2-3

1

20

High-throughput

0.439

High

949789

KR101
Keratin-associated protein 10-1

1

20

High-throughput

0.439

High

950023

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

1120555

NID2
Nidogen-2

1

12

High-throughput

0.439

High

1340369

CEP70
Centrosomal protein of 70 kDa

1

4

High-throughput

0.417

High

1156356

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

2

0

High-throughput

0.316

High

1160378

OBF1
POU domain class 2-associating factor 1

2

0

High-throughput

0.316

High

1186719

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1276345

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.316

High

1295118

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1418294

CNFN
Cornifelin

2

0

High-throughput

0.316

High

1454008

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.316

High

215675

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.279

Low

1326751

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

728833

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.268

Low

1191407

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025