Protein: FTO
Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-)

Gene: FTO
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9C0B1

Gene Ontology (top 5):
GO:0001659 - temperature homeostasis
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1420689

ZMAT3
Zinc finger matrin-type protein 3

3

0

High-throughput

0.638

High

1413720

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

1

High-throughput

0.628

High

326210

ALX3
Homeobox protein aristaless-like 3

2

0

High-throughput

0.602

High

659703

NFYA
Nuclear transcription factor Y subunit alpha

2

0

High-throughput

0.602

High

1234710

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.602

High

1420703

ZN232
Zinc finger protein 232

2

0

High-throughput

0.602

High

164636

TNPO2
Transportin-2

2

0

High-throughput

0.580

High

1119783

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

0

High-throughput

0.580

High

1156089

ZNF77
Zinc finger protein 77

2

0

High-throughput

0.580

High

1180019

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.580

High

1180821

KLH38
Kelch-like protein 38

2

0

High-throughput

0.580

High

1244218

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.580

High

1289297

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1363734

SHC3
SHC-transforming protein 3

2

0

High-throughput

0.580

High

1371163

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

2

0

High-throughput

0.580

High

1420692

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

0

High-throughput

0.580

High

1420695

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

1420698

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

1420701

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

High-throughput

0.580

High

1420704

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

0

High-throughput

0.580

High

1231793

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

1

High-throughput

0.553

High

1420702

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

2

High-throughput

0.549

High

946454

MTPN
Myotrophin

1

1

High-throughput

0.536

High

287473

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

614755

ARY1
Arylamine N-acetyltransferase 1

1

0

High-throughput

0.513

High

898255

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

High-throughput

0.513

High

1025227

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.513

High

1279581

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

0

High-throughput

0.513

High

1400506

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

0

High-throughput

0.513

High

1420690

MAGF1
Melanoma-associated antigen F1

1

0

High-throughput

0.513

High

1420691

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1420696

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

948078

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

2

High-throughput

0.489

High

1208213

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

1

High-throughput

0.489

High

1208237

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

2

High-throughput

0.489

High

1247976

ANR11
Ankyrin repeat domain-containing protein 11

1

2

High-throughput

0.481

High

185999

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1255432

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1420705

X5D778
Ankyrin repeat domain 11 isoform A

1

2

High-throughput

0.470

High

279486

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

315990

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

417733

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

589621

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

607713

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

Small-scale

0.458

High

769107

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831386

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

862975

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

981072

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1096631

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1292449

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.458

High

1383242

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1415857

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1420688

ZN576
Zinc finger protein 576

1

1

High-throughput

0.445

High

330306

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

404901

PRIO
Major prion protein

1

0

High-throughput

0.426

High

598769

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

952330

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.426

High

1314402

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.426

High

1405162

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.426

High

1416714

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

1420694

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1208278

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

2

High-throughput

0.407

High

329879

OR5F1
Olfactory receptor 5F1

2

0

High-throughput

0.328

High

387889

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

616804

SDC1
Syndecan-1

2

0

High-throughput

0.328

High

1393559

DIRA2
GTP-binding protein Di-Ras2

2

0

High-throughput

0.328

High

1402861

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

350499

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

0

High-throughput

0.316

High

351602

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

0

High-throughput

0.316

High

1420697

GBG13

2

0

High-throughput

0.316

High

106609

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

333513

MPZL1
Myelin protein zero-like protein 1

1

0

High-throughput

0.279

Low

652248

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.279

Low

1158826

CART

1

0

High-throughput

0.279

Low

1420687

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

0

High-throughput

0.279

Low

1420693

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

0

High-throughput

0.279

Low

1420699

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

1420700

PGAP2
Acyltransferase PGAP2

1

0

High-throughput

0.279

Low

1104085

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025