Protein: EMC8
ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)

Gene: EMC8
Organism: Homo sapiens
Interactions: 228
UniProt ID: O43402

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

202888

EMC2
ER membrane protein complex subunit 2

16

5

Small-scale

0.986

High

202922

EMC5
ER membrane protein complex subunit 5

5

1

High-throughput

0.932

High

202976

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

4

1

High-throughput

0.704

High

202925

EMC1
ER membrane protein complex subunit 1

4

2

High-throughput

0.699

High

202991

EMC3
ER membrane protein complex subunit 3

4

2

High-throughput

0.697

High

202902

EMC4
ER membrane protein complex subunit 4

3

2

High-throughput

0.675

High

202851

VMAT1
Chromaffin granule amine transporter

3

0

High-throughput

0.638

High

202881

TRDN
Triadin

2

1

High-throughput

0.628

High

202938

LPAR1
Lysophosphatidic acid receptor 1

2

1

High-throughput

0.628

High

202964

EMC6
ER membrane protein complex subunit 6

2

1

High-throughput

0.628

High

202854

SC61B
Protein transport protein Sec61 subunit beta

3

0

High-throughput

0.628

High

202830

CALX
Calnexin

2

1

High-throughput

0.611

High

202811

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.585

High

202812

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.585

High

202927

RN149
E3 ubiquitin-protein ligase RNF149

2

3

Small-scale

0.584

High

48192

ESYT2
Extended synaptotagmin-2

2

2

High-throughput

0.571

High

202926

DHB11
Estradiol 17-beta-dehydrogenase 11

2

2

High-throughput

0.571

High

202847

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.547

High

202876

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.547

High

202966

LNP
Endoplasmic reticulum junction formation protein lunapark

2

0

High-throughput

0.547

High

198492

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.536

High

202797

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.536

High

202802

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.536

High

202821

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

202824

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

202827

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

202828

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.536

High

202835

MATR3
Matrin-3

1

1

High-throughput

0.536

High

202837

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.536

High

202838

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.536

High

202842

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.536

High

202849

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

202850

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

202853

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

202859

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.536

High

202860

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

202861

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

202862

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.536

High

202863

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.536

High

202864

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.536

High

202865

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

202866

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

202867

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.536

High

202868

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

202870

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.536

High

202873

RL24
Large ribosomal subunit protein eL24

1

1

High-throughput

0.536

High

202878

DHX9
ATP-dependent RNA helicase A

1

1

High-throughput

0.536

High

202880

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

1

High-throughput

0.536

High

202883

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.536

High

202885

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

2

High-throughput

0.536

High

202904

EMC10
ER membrane protein complex subunit 10

1

1

High-throughput

0.536

High

202912

KTN1
Kinectin

1

2

High-throughput

0.536

High

202943

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

202957

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.536

High

202980

FBX6
F-box only protein 6

1

1

High-throughput

0.536

High

202992

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

202998

UBQL2
Ubiquilin-2

1

1

High-throughput

0.536

High

202999

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

203003

PRC2C
Protein PRRC2C

1

1

High-throughput

0.536

High

123431

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

149490

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

202791

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.513

High

202807

K2C6A
Keratin, type II cytoskeletal 6A

1

0

High-throughput

0.513

High

202816

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

202832

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

202843

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

202903

WDR44
WD repeat-containing protein 44

1

0

High-throughput

0.513

High

202915

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

202920

D106A
Beta-defensin 106

1

0

High-throughput

0.513

High

202924

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.513

High

202933

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

202960

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

202981

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.513

High

202984

PARVA
Alpha-parvin

1

0

High-throughput

0.513

High

202852

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.489

High

202891

SYK
Lysine--tRNA ligase

1

3

High-throughput

0.489

High

202940

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.489

High

202813

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

163672

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

202790

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

202815

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

202823

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

202833

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

202855

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.479

High

202856

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

202857

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

202875

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

202877

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

202898

TECT1
Tectonic-1

1

2

High-throughput

0.479

High

202911

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.479

High

202914

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

202916

MIRO2
Mitochondrial Rho GTPase 2

1

7

High-throughput

0.479

High

202947

TECT2
Tectonic-2

1

2

High-throughput

0.479

High

202948

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

202952

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

202969

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

202970

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

202979

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

202983

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

203000

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

202792

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.458

High

202804

RASK
GTPase KRas

1

0

High-throughput

0.458

High

202822

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

202826

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

202836

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

202844

EMD
Emerin

1

0

High-throughput

0.458

High

202845

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

202871

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

202879

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

202884

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

202886

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

202895

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

202908

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

202917

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

202944

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

202950

TM237
Transmembrane protein 237

1

0

High-throughput

0.458

High

202951

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

202955

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

202956

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

202963

DERL1
Derlin-1

1

0

High-throughput

0.458

High

202974

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

202978

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

202989

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

202993

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

202995

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

202997

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

99757

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

202793

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

202795

STAM2
Signal transducing adapter molecule 2

1

2

High-throughput

0.445

High

202800

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

202801

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

202814

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.445

High

202818

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

202829

CALR
Calreticulin

1

1

High-throughput

0.445

High

202831

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.445

High

202893

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

202896

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.445

High

202901

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

202919

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

202931

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

202936

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

202942

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.445

High

202949

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

202961

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.445

High

202972

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

202977

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

202996

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

203001

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

203002

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

203006

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

120223

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.437

High

202808

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.437

High

202905

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

202937

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

202987

CLC5A
C-type lectin domain family 5 member A

1

2

High-throughput

0.437

High

50057

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

58018

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

199240

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

202794

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

202799

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.426

High

202803

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

202819

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

202820

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

202834

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

202839

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

202840

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

202846

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

202848

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

202858

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

202869

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

202872

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

202874

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

202882

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

202887

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

202889

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

202890

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

202892

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

202894

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

202899

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

202906

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

202923

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

202928

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

202932

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

202934

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

202946

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

202958

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.426

High

202959

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.426

High

202962

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

202965

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

202971

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

202975

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.426

High

202982

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

202990

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

203005

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

202900

BCL7A
B-cell CLL/lymphoma 7 protein family member A

2

0

High-throughput

0.328

High

202954

KCNKG
Potassium channel subfamily K member 16

2

0

High-throughput

0.318

High

202796

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

202798

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

202805

GON1
Progonadoliberin-1

1

0

High-throughput

0.279

Low

202806

IFN21
Interferon alpha-21

1

0

High-throughput

0.279

Low

202809

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

202810

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

202817

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

202825

EGLN
Endoglin

1

0

High-throughput

0.279

Low

202897

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.279

Low

202910

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.279

Low

202918

F186B
Protein FAM186B

1

0

High-throughput

0.279

Low

202930

OR4N2
Olfactory receptor 4N2

1

0

High-throughput

0.279

Low

202941

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.279

Low

202973

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

202994

ZN581
Zinc finger protein 581

1

0

High-throughput

0.279

Low

203004

OR1A2
Olfactory receptor 1A2

1

0

High-throughput

0.279

Low

202907

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.249

Low

202913

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

202921

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

202935

5HT3C
5-hydroxytryptamine receptor 3C

1

0

High-throughput

0.249

Low

202939

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

202945

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

202967

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.249

Low

200954

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.232

Low

202841

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

202909

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.232

Low

202929

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

202953

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

202968

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.232

Low

202985

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

202986

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

202988

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024