Protein: LAGE3
EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2)

Gene: LAGE3
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q14657

Gene Ontology (top 5):
GO:0000408 - EKC/KEOPS complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0008033 - tRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1129277

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

8

2

Small-scale

0.967

High

1129267

GON7
EKC/KEOPS complex subunit GON7

6

0

Small-scale

0.904

High

1129261

PRPK
EKC/KEOPS complex subunit TP53RK

5

1

Small-scale

0.716

High

1129250

NUP43
Nucleoporin Nup43

4

0

High-throughput

0.661

High

294926

POP7
Ribonuclease P protein subunit p20

4

0

High-throughput

0.660

High

1129288

TPRKB
EKC/KEOPS complex subunit TPRKB

3

1

Small-scale

0.650

High

303329

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3

0

High-throughput

0.646

High

1129285

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

6

High-throughput

0.606

High

1129266

CC28B
Coiled-coil domain-containing protein 28B

2

0

High-throughput

0.602

High

700517

PSB9
Proteasome subunit beta type-9

2

0

High-throughput

0.589

High

1007561

PRAME
Melanoma antigen preferentially expressed in tumors

2

0

Small-scale

0.585

High

63196

VP37C
Vacuolar protein sorting-associated protein 37C

2

0

High-throughput

0.580

High

269202

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

571975

TRI27
Zinc finger protein RFP

2

0

High-throughput

0.580

High

783271

TRI23
E3 ubiquitin-protein ligase TRIM23

2

0

High-throughput

0.580

High

1093616

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

1129248

PNMA1
Paraneoplastic antigen Ma1

2

0

High-throughput

0.580

High

1129251

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.580

High

1129286

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

593664

BGAL
Beta-galactosidase

2

0

High-throughput

0.576

High

60655

HYKK
Hydroxylysine kinase

2

1

High-throughput

0.560

High

950478

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

1129279

PKHJ1
Pleckstrin homology domain-containing family J member 1

2

3

High-throughput

0.553

High

1112836

CUL2
Cullin-2

2

0

Small-scale

0.547

High

1129257

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

848200

MAGA2
Melanoma-associated antigen 2

1

3

High-throughput

0.536

High

1129235

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

1

High-throughput

0.536

High

1129242

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.536

High

1129245

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1129253

RUFY2
RUN and FYVE domain-containing protein 2

1

1

High-throughput

0.536

High

1129263

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.536

High

1129283

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

1

High-throughput

0.536

High

2924

A0A0C4DGM4
Hydroxylysine kinase

1

1

High-throughput

0.515

High

62210

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.513

High

292349

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.513

High

507193

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

630519

RAB3B
Ras-related protein Rab-3B

1

0

High-throughput

0.513

High

1032583

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

0

High-throughput

0.513

High

1129258

CNDP2
Cytosolic non-specific dipeptidase

1

0

High-throughput

0.513

High

1129262

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

1129269

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.513

High

1129280

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.513

High

565618

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.489

High

845024

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.489

High

931235

AT12A
Potassium-transporting ATPase alpha chain 2

1

2

High-throughput

0.489

High

1047215

ATP7A
Copper-transporting ATPase 1

1

2

High-throughput

0.489

High

1129281

ST32B
Serine/threonine-protein kinase 32B

1

1

High-throughput

0.489

High

1129284

CYH4
Cytohesin-4

1

1

High-throughput

0.489

High

1129289

TCAF1
TRPM8 channel-associated factor 1

1

2

High-throughput

0.489

High

1129268

TRI55
Tripartite motif-containing protein 55

1

4

High-throughput

0.481

High

1122482

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

293691

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

970501

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1129228

ELOC
Elongin-C

1

0

Small-scale

0.458

High

1129229

ELOB
Elongin-B

1

0

Small-scale

0.458

High

1129230

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.458

High

1129244

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1129271

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1129272

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1129274

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1129275

MT21D
Protein N-lysine methyltransferase METTL21D

1

0

High-throughput

0.458

High

848384

MAGA6
Melanoma-associated antigen 6

1

3

High-throughput

0.445

High

848962

MAGAC
Melanoma-associated antigen 12

1

3

High-throughput

0.445

High

1081736

FP100
Fanconi anemia core complex-associated protein 100

1

1

High-throughput

0.445

High

1129236

DCAF8
DDB1- and CUL4-associated factor 8

1

1

High-throughput

0.445

High

1129256

VWCE
von Willebrand factor C and EGF domain-containing protein

1

1

High-throughput

0.445

High

2134

PAL4C
Peptidyl-prolyl cis-trans isomerase A-like 4C

1

0

High-throughput

0.426

High

344195

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

983483

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

High-throughput

0.426

High

1107716

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

1129234

CERKL
Ceramide kinase-like protein

1

0

High-throughput

0.426

High

1129237

ZN772
Zinc finger protein 772

1

0

High-throughput

0.426

High

1129243

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.426

High

1129246

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.426

High

1129252

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.426

High

1129254

IFT81
Intraflagellar transport protein 81 homolog

1

0

High-throughput

0.426

High

1129260

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.426

High

1129265

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.426

High

1129270

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.426

High

1129278

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.426

High

1129282

CRNN
Cornulin

1

0

High-throughput

0.426

High

844773

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

1129238

K1C40
Keratin, type I cytoskeletal 40

3

0

High-throughput

0.352

High

65045

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

70206

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

528676

PPGB
Lysosomal protective protein

2

0

High-throughput

0.313

High

1129240

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.313

High

1129249

PDZD8
PDZ domain-containing protein 8

2

0

High-throughput

0.313

High

548498

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.279

Low

914049

SPSY
Spermine synthase

1

0

High-throughput

0.279

Low

914150

HXK3
Hexokinase-3

1

0

High-throughput

0.279

Low

1129239

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

1129255

UBXN4
UBX domain-containing protein 4

1

0

High-throughput

0.279

Low

1129264

F118B
Protein FAM118B

1

0

High-throughput

0.279

Low

1129273

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.279

Low

1129276

NJMU
Protein Njmu-R1

1

0

High-throughput

0.279

Low

1129233

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

380030

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

1129231

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

654499

FBLN1
Fibulin-1

1

0

High-throughput

0.232

Low

960369

SMS
Somatostatin

1

0

High-throughput

0.232

Low

1129232

ANO4
Anoctamin-4

1

0

High-throughput

0.232

Low

1129241

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

0

High-throughput

0.232

Low

1129247

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

1129259

CI085
Uncharacterized protein C9orf85

1

0

High-throughput

0.232

Low

1129287

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025