Protein: MED17
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)

Gene: MED17
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q9NVC6

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1312766

MED18
Mediator of RNA polymerase II transcription subunit 18

7

1

Small-scale

0.967

High

206655

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.932

High

1074730

MED22
Mediator of RNA polymerase II transcription subunit 22

5

1

Small-scale

0.927

High

1334002

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.906

High

1342918

MED4
Mediator of RNA polymerase II transcription subunit 4

4

1

High-throughput

0.906

High

1293705

MED30
Mediator of RNA polymerase II transcription subunit 30

4

1

Small-scale

0.903

High

225423

MED14
Mediator of RNA polymerase II transcription subunit 14

4

3

Small-scale

0.895

High

270534

MED6
Mediator of RNA polymerase II transcription subunit 6

4

1

Small-scale

0.895

High

1291849

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

High-throughput

0.871

High

1346440

MED11
Mediator of RNA polymerase II transcription subunit 11

3

1

High-throughput

0.871

High

1346453

MED31
Mediator of RNA polymerase II transcription subunit 31

3

1

High-throughput

0.871

High

181466

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.770

High

826364

CDK8
Cyclin-dependent kinase 8

14

4

Small-scale

0.761

High

1312299

MED10
Mediator of RNA polymerase II transcription subunit 10

11

1

Small-scale

0.760

High

1346437

MED29
Mediator of RNA polymerase II transcription subunit 29

7

1

Small-scale

0.751

High

625063

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.748

High

1328953

MED28
Mediator of RNA polymerase II transcription subunit 28

7

1

Small-scale

0.748

High

1314884

CDK19
Cyclin-dependent kinase 19

7

4

Small-scale

0.746

High

48734

MED19
Mediator of RNA polymerase II transcription subunit 19

10

0

Small-scale

0.726

High

1076204

MED1
Mediator of RNA polymerase II transcription subunit 1

9

0

Small-scale

0.721

High

1274353

MED12
Mediator of RNA polymerase II transcription subunit 12

5

1

High-throughput

0.718

High

1346436

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.705

High

1158926

MED27
Mediator of RNA polymerase II transcription subunit 27

4

1

Small-scale

0.702

High

313469

MED26
Mediator of RNA polymerase II transcription subunit 26

4

1

High-throughput

0.699

High

624518

CCNC
Cyclin-C

4

1

High-throughput

0.686

High

1037104

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.674

High

1346446

MED23
Mediator of RNA polymerase II transcription subunit 23

3

2

High-throughput

0.671

High

265367

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

High-throughput

0.667

High

1061333

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

5

High-throughput

0.667

High

1346451

MED16
Mediator of RNA polymerase II transcription subunit 16

3

1

High-throughput

0.667

High

913964

RPB7
DNA-directed RNA polymerase II subunit RPB7

4

0

High-throughput

0.664

High

1346444

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

High-throughput

0.662

High

1269737

ESR2
Estrogen receptor beta

3

5

Small-scale

0.660

High

1301094

MED15
Mediator of RNA polymerase II transcription subunit 15

3

1

Small-scale

0.656

High

1174780

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

2

High-throughput

0.650

High

245002

BRD4
Bromodomain-containing protein 4

3

1

Small-scale

0.640

High

1221373

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.628

High

1174968

MED25
Mediator of RNA polymerase II transcription subunit 25

2

1

Small-scale

0.611

High

1206162

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

1

High-throughput

0.611

High

177727

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

583816

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

638412

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

666979

TKT
Transketolase

2

0

High-throughput

0.602

High

583599

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.585

High

677024

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

854481

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

897641

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

370538

ESR1
Estrogen receptor

2

5

Small-scale

0.585

High

847094

SMCA4
Transcription activator BRG1

2

1

Small-scale

0.585

High

1271457

KAT2A
Histone acetyltransferase KAT2A

2

2

Small-scale

0.571

High

738995

SRBP1
Sterol regulatory element-binding protein 1

2

0

Small-scale

0.569

High

1281420

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

500448

THA
Thyroid hormone receptor alpha

2

4

Small-scale

0.552

High

749891

BRCA1
Breast cancer type 1 susceptibility protein

2

1

Small-scale

0.552

High

1346442

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.537

High

254518

ROCK2
Rho-associated protein kinase 2

1

1

High-throughput

0.536

High

613021

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.536

High

800538

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.536

High

1116577

LARP7
La-related protein 7

1

1

High-throughput

0.536

High

1182962

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.536

High

1332262

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

2

High-throughput

0.536

High

1346441

STK26
Serine/threonine-protein kinase 26

1

1

High-throughput

0.536

High

1346457

STK24
Serine/threonine-protein kinase 24

1

1

High-throughput

0.536

High

59428

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.513

High

124095

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

161463

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.513

High

207117

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

212183

HTSF1
17S U2 SnRNP complex component HTATSF1

1

0

High-throughput

0.513

High

269272

WBP4
WW domain-binding protein 4

1

0

High-throughput

0.513

High

314688

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.513

High

345555

FOS
Protein c-Fos

1

0

High-throughput

0.513

High

358909

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

554525

GATA1
Erythroid transcription factor

1

0

Small-scale

0.513

High

664035

T2EA
General transcription factor IIE subunit 1

1

0

High-throughput

0.513

High

984540

KPCD
Protein kinase C delta type

1

0

High-throughput

0.513

High

1033978

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.513

High

1036491

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.513

High

1060237

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.513

High

1075818

CIP4
Cdc42-interacting protein 4

1

0

High-throughput

0.513

High

1078498

TOM34
Mitochondrial import receptor subunit TOM34

1

0

High-throughput

0.513

High

1147539

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.513

High

1160900

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1230929

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

1236222

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.513

High

1245040

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

1262001

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.513

High

1272867

GPKOW
G-patch domain and KOW motifs-containing protein

1

0

High-throughput

0.513

High

1284938

ARK2N
Protein ARK2N

1

0

High-throughput

0.513

High

1288133

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1299999

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

1307517

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.513

High

1309135

CMS1
Protein CMSS1

1

0

High-throughput

0.513

High

1319077

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.513

High

1342617

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

1346438

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.513

High

1346448

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.513

High

1346450

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

1346452

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

1346455

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.513

High

831728

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

782672

HNF4A
Hepatocyte nuclear factor 4-alpha

1

5

Small-scale

0.501

High

1035213

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.489

High

1058405

MESD
LRP chaperone MESD

1

1

High-throughput

0.489

High

1329368

SLK
STE20-like serine/threonine-protein kinase

1

3

High-throughput

0.489

High

1346445

GPN3
GPN-loop GTPase 3

1

1

High-throughput

0.489

High

387603

P53
Cellular tumor antigen p53

1

0

Small-scale

0.480

High

781463

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.480

High

1063642

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.480

High

1346456

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

266437

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

295307

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

295565

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.479

High

304666

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.479

High

348025

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

377732

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

487795

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

738894

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

1078682

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1078764

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

1336396

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.479

High

1315452

HEMGN
Hemogen

1

0

Small-scale

0.460

High

228854

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

246617

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

266507

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

297938

ST65G
STAGA complex 65 subunit gamma

1

0

Small-scale

0.458

High

320031

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

455924

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

553854

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

808965

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

841334

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

854377

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

864998

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

918015

H4
Histone H4

1

0

High-throughput

0.458

High

921176

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

964445

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1019145

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1048251

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

1076297

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1132749

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1137960

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1173771

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1174235

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

1236527

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1242670

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1299688

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1306546

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1332184

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1346439

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1346443

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1346447

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.458

High

73045

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

4

High-throughput

0.445

High

91313

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1128610

Q5JWT2
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.445

High

1146883

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1242465

PAPD5
Terminal nucleotidyltransferase 4B

1

1

High-throughput

0.437

High

1301395

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1305959

BARD1
BRCA1-associated RING domain protein 1

1

0

Small-scale

0.426

High

1346454

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

103507

G4U4J3
PAP associated domain containing 5

1

2

High-throughput

0.407

High

329050

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

275331

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.279

Low

276055

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.279

Low

396425

APOD
Apolipoprotein D

1

0

High-throughput

0.279

Low

448003

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.279

Low

935836

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.279

Low

961848

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1061962

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

0

High-throughput

0.279

Low

1062688

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

1232137

RHG18
Rho GTPase-activating protein 18

1

0

High-throughput

0.279

Low

1252890

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1289147

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.279

Low

1295761

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

1298233

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.279

Low

1328014

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.279

Low

1331050

E41L1
Band 4.1-like protein 1

1

0

High-throughput

0.279

Low

1346449

RT33
Small ribosomal subunit protein mS33

1

0

High-throughput

0.279

Low

361614

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

385597

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1150703

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1171938

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

2134

PAL4C
Peptidyl-prolyl cis-trans isomerase A-like 4C

1

0

High-throughput

0.232

Low

473929

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024