Protein: RDHE2
Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)

Gene: RDHE2, SDR16C5
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q8N3Y7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0004745 - all-trans-retinol dehydrogenase (NAD+) activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391638

FRIH
Ferritin heavy chain

2

1

High-throughput

0.628

High

1325561

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.628

High

1325557

RDHE2
Epidermal retinol dehydrogenase 2

1

15

High-throughput

0.621

High

1325563

SENP2
Sentrin-specific protease 2

2

1

High-throughput

0.606

High

1325567

HSFX1
Heat shock transcription factor, X-linked

2

1

High-throughput

0.606

High

1325571

NDRG4
Protein NDRG4

2

1

High-throughput

0.606

High

1325562

FUND2
FUN14 domain-containing protein 2

2

0

High-throughput

0.580

High

885169

TTPA
Alpha-tocopherol transfer protein

2

5

High-throughput

0.553

High

1050858

DCE2
Glutamate decarboxylase 2

2

3

High-throughput

0.553

High

1111940

SNX1
Sorting nexin-1

2

1

High-throughput

0.553

High

1165338

SYT16
Synaptotagmin-16

2

1

High-throughput

0.553

High

1325558

EXTL1
Exostosin-like 1

1

1

High-throughput

0.541

High

1325568

NLK
Serine/threonine-protein kinase NLK

1

1

High-throughput

0.541

High

552308

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.536

High

602814

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

876365

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.536

High

943092

STX17
Syntaxin-17

1

1

High-throughput

0.536

High

1292317

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.536

High

1325564

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1325570

PHF11
PHD finger protein 11

1

2

High-throughput

0.536

High

1325572

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

194473

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

943485

DSCR6
Protein ripply3

1

0

High-throughput

0.513

High

1325560

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.513

High

1325569

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.513

High

733394

CCR1
C-C chemokine receptor type 1

1

4

High-throughput

0.489

High

914155

HXK3
Hexokinase-3

1

1

High-throughput

0.489

High

1023833

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.489

High

1181324

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

1325559

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.489

High

461699

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

468589

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

1063980

ECHP
Peroxisomal bifunctional enzyme

1

6

High-throughput

0.470

High

47546

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

554235

BMP4
Bone morphogenetic protein 4

1

1

High-throughput

0.445

High

1325566

TBA8
Tubulin alpha-8 chain

1

3

High-throughput

0.439

High

261221

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.407

High

1325565

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

255123

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

1315960

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

906318

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025