Protein: LSS
Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)

Gene: LSS
Organism: Homo sapiens
Interactions: 60
UniProt ID: P48449

Gene Ontology (top 5):
GO:0000250 - lanosterol synthase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005811 - lipid droplet
GO:0006694 - steroid biosynthetic process
GO:0006695 - cholesterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

819101

PNKD
Probable hydrolase PNKD

3

0

High-throughput

0.638

High

819106

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.585

High

303887

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

819102

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.580

High

819108

CIB1
Calcium and integrin-binding protein 1

2

0

High-throughput

0.580

High

819088

NTCP
Hepatic sodium/bile acid cotransporter

2

1

High-throughput

0.553

High

819090

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.553

High

724708

MYH9
Myosin-9

1

0

High-throughput

0.513

High

819079

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

819082

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

819095

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.513

High

819110

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.513

High

819116

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

0

High-throughput

0.513

High

377176

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

162500

XPO1
Exportin-1

1

0

High-throughput

0.458

High

226814

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

742122

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

819097

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

611398

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

1

High-throughput

0.439

High

394317

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.438

High

819086

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

121454

TR10A
Tumor necrosis factor receptor superfamily member 10A

2

0

High-throughput

0.328

High

456309

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.328

High

819084

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

819111

KISHB
Protein kish-B

2

0

High-throughput

0.316

High

819109

GPR35
G-protein coupled receptor 35

1

0

High-throughput

0.282

High

50810

NTM2F
NUT family member 2F

1

0

High-throughput

0.279

Low

195371

DHX15
ATP-dependent RNA helicase DHX15

1

0

High-throughput

0.279

Low

277290

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

323634

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

819078

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.279

Low

819080

SUMO1
Small ubiquitin-related modifier 1

1

0

High-throughput

0.279

Low

819083

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

819087

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.279

Low

819089

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

819091

ZN718
Zinc finger protein 718

1

0

High-throughput

0.279

Low

819092

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

0

High-throughput

0.279

Low

819093

RAB12
Ras-related protein Rab-12

1

0

High-throughput

0.279

Low

819094

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.279

Low

819096

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

819100

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

819103

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

819104

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

819105

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

819107

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

819113

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

819115

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.279

Low

130791

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.249

Low

384467

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

552193

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

594715

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.249

Low

650632

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

719934

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

819077

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

819081

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

819085

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

819099

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

819112

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

819114

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

819098

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024