Protein: AMRP
Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)

Gene: AMRP, LRPAP1
Organism: Homo sapiens
Interactions: 167
UniProt ID: P30533

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0002091 - negative regulation of receptor internalization
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720461

VLDLR
Very low-density lipoprotein receptor

6

10

Small-scale

0.954

High

720464

LRP1
Prolow-density lipoprotein receptor-related protein 1

6

10

Small-scale

0.951

High

720518

SORL
Sortilin-related receptor

6

11

Small-scale

0.949

High

720473

LRP8
Low-density lipoprotein receptor-related protein 8

6

10

Small-scale

0.947

High

720462

LRP2
Low-density lipoprotein receptor-related protein 2

5

10

Small-scale

0.928

High

376483

LDLR
Low-density lipoprotein receptor

4

10

Small-scale

0.906

High

270539

LRP4
Low-density lipoprotein receptor-related protein 4

2

10

High-throughput

0.811

High

720545

LRP1B
Low-density lipoprotein receptor-related protein 1B

2

10

High-throughput

0.811

High

720526

SORT
Sortilin

5

1

Small-scale

0.710

High

270776

ROCK2
Rho-associated protein kinase 2

2

0

High-throughput

0.602

High

720465

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

720490

SYDE2
Rho GTPase-activating protein SYDE2

2

1

High-throughput

0.571

High

602868

INAR1
Interferon alpha/beta receptor 1

1

1

Small-scale

0.561

High

720547

GMIP
GEM-interacting protein

2

0

High-throughput

0.547

High

720450

TTC3
E3 ubiquitin-protein ligase TTC3

1

1

High-throughput

0.541

High

582311

ARSA
Arylsulfatase A

1

1

High-throughput

0.536

High

698420

CALX
Calnexin

1

1

High-throughput

0.536

High

720534

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

720522

CALR3
Calreticulin-3

2

1

High-throughput

0.533

High

720537

RTN4
Reticulon-4

1

0

High-throughput

0.518

High

720551

RPGFL
Rap guanine nucleotide exchange factor-like 1

1

1

High-throughput

0.515

High

421571

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

137497

BT3A1
Butyrophilin subfamily 3 member A1

1

0

High-throughput

0.513

High

378837

CD4
T-cell surface glycoprotein CD4

1

0

High-throughput

0.513

High

699543

IL1R2
Interleukin-1 receptor type 2

1

0

High-throughput

0.513

High

720452

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.513

High

720525

SRPK1
SRSF protein kinase 1

1

0

High-throughput

0.513

High

720535

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

122920

SGK1
Serine/threonine-protein kinase Sgk1

1

0

High-throughput

0.493

High

680672

CATS
Cathepsin S

1

0

High-throughput

0.493

High

692862

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

720479

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.493

High

720553

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.493

High

647331

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.489

High

659172

SP100
Nuclear autoantigen Sp-100

1

1

High-throughput

0.489

High

720467

GNDS
Ral guanine nucleotide dissociation stimulator

1

1

Small-scale

0.481

High

217393

E41L2
Band 4.1-like protein 2

1

1

High-throughput

0.479

High

460775

CATB
Cathepsin B

1

1

High-throughput

0.479

High

566573

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.479

High

648434

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.479

High

720142

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.479

High

720442

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.479

High

720443

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.479

High

720444

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.479

High

720468

DNJC3
DnaJ homolog subfamily C member 3

1

3

High-throughput

0.479

High

720480

PDIA6
Protein disulfide-isomerase A6

1

2

High-throughput

0.479

High

720487

EPHAA
Ephrin type-A receptor 10

1

1

High-throughput

0.479

High

720505

DJC10
DnaJ homolog subfamily C member 10

1

4

High-throughput

0.479

High

720513

DJB14
DnaJ homolog subfamily B member 14

1

4

High-throughput

0.479

High

720514

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

1

High-throughput

0.479

High

720542

DJB12
DnaJ homolog subfamily B member 12

1

4

High-throughput

0.479

High

720548

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.479

High

400355

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

Small-scale

0.460

High

720438

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

212163

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

720476

SRC8
Src substrate cortactin

1

0

High-throughput

0.458

High

217878

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

229661

CALU
Calumenin

1

0

High-throughput

0.458

High

359597

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

413266

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

476569

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.458

High

534690

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

593027

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

720440

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

720441

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

720447

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

720449

EFNA4
Ephrin-A4

1

0

High-throughput

0.458

High

720455

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

720457

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

720463

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

720472

CUL3
Cullin-3

1

0

High-throughput

0.458

High

720506

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

720519

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

720529

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

720539

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

720546

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

720549

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.458

High

480722

LEG1
Galectin-1

1

1

High-throughput

0.445

High

609590

LEG3
Galectin-3

1

1

High-throughput

0.445

High

720531

CD244
Natural killer cell receptor 2B4

1

1

High-throughput

0.445

High

187014

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.438

High

318449

TOX4
TOX high mobility group box family member 4

1

1

High-throughput

0.437

High

720445

RBM25
RNA-binding protein 25

1

1

High-throughput

0.437

High

720483

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.437

High

720485

TECT1
Tectonic-1

1

1

High-throughput

0.437

High

720493

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

720504

PHF6
PHD finger protein 6

1

1

High-throughput

0.437

High

720510

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.437

High

720523

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

4

High-throughput

0.437

High

720533

DJC18
DnaJ homolog subfamily C member 18

1

3

High-throughput

0.437

High

720540

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.437

High

720543

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.437

High

720550

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

482675

SPRC
SPARC

1

0

High-throughput

0.426

High

529173

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

720454

CD81
CD81 antigen

1

0

High-throughput

0.426

High

720552

FBX2
F-box only protein 2

1

0

High-throughput

0.426

High

720521

LCOR
Ligand-dependent corepressor

2

0

High-throughput

0.328

High

720446

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.282

High

720474

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.282

High

720556

ETV7
Transcription factor ETV7

1

0

High-throughput

0.282

High

163412

MEIS2
Homeobox protein Meis2

1

0

High-throughput

0.279

Low

251521

CCNT1
Cyclin-T1

1

0

High-throughput

0.279

Low

720437

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.279

Low

720466

TP53B
TP53-binding protein 1

1

0

High-throughput

0.279

Low

720469

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.279

Low

720477

CAPR1
Caprin-1

1

0

High-throughput

0.279

Low

720499

PCLI1
PTB-containing, cubilin and LRP1-interacting protein

1

0

High-throughput

0.279

Low

720502

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.279

Low

720503

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

720507

MICU2
Calcium uptake protein 2, mitochondrial

1

0

High-throughput

0.279

Low

720508

AN36B
Ankyrin repeat domain-containing protein 36B

1

0

High-throughput

0.279

Low

720536

JADE2
E3 ubiquitin-protein ligase Jade-2

1

0

High-throughput

0.279

Low

720544

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.279

Low

96619

E9PAV9
G patch domain-containing protein 4

1

0

High-throughput

0.249

Low

140764

NOP56
Nucleolar protein 56

1

0

High-throughput

0.249

Low

215038

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.249

Low

228186

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.249

Low

336074

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

0

High-throughput

0.249

Low

541848

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.249

Low

559880

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.249

Low

634824

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.249

Low

675380

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.249

Low

720439

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.249

Low

720448

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

720451

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.249

Low

720456

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

720458

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.249

Low

720459

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

720460

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.249

Low

720470

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.249

Low

720471

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.249

Low

720475

ELOA1
Elongin-A

1

0

High-throughput

0.249

Low

720478

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.249

Low

720481

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.249

Low

720482

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.249

Low

720484

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.249

Low

720486

FA76B
Protein FAM76B

1

0

High-throughput

0.249

Low

720489

SPOUT
28S rRNA

1

0

High-throughput

0.249

Low

720491

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.249

Low

720494

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.249

Low

720495

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.249

Low

720496

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

720497

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

720498

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

720500

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.249

Low

720501

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.249

Low

720509

NGEF
Ephexin-1

1

0

High-throughput

0.249

Low

720512

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.249

Low

720515

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.249

Low

720516

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.249

Low

720517

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

720520

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.249

Low

720524

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.249

Low

720527

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.249

Low

720528

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

720530

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.249

Low

720532

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.249

Low

720538

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.249

Low

720541

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.249

Low

720555

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.249

Low

62456

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

720453

SUMO3
Small ubiquitin-related modifier 3

1

0

Small-scale

0.232

Low

720488

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.232

Low

720492

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.232

Low

720511

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

720554

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025