Protein: NSUN5
28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)

Gene: NSUN5
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q96P11

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0009383 - rRNA (cytosine-C5-)-methyltransferase activity
GO:0014003 - oligodendrocyte development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1358649

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

0

High-throughput

0.602

High

372881

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

831264

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

1185864

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

5

High-throughput

0.575

High

396743

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

1053725

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

4

High-throughput

0.541

High

960528

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.536

High

1054633

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.536

High

1093031

CDC16
Cell division cycle protein 16 homolog

1

2

High-throughput

0.536

High

1399330

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1399339

EXOS1
Exosome complex component CSL4

1

2

High-throughput

0.536

High

1111203

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1136052

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

185942

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

174055

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.489

High

1042054

LMNB2
Lamin-B2

1

3

High-throughput

0.489

High

1385971

ZN653
Zinc finger protein 653

1

8

High-throughput

0.489

High

406524

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

485346

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

552861

TPR
Nucleoprotein TPR

1

3

High-throughput

0.479

High

589449

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

607633

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

4

High-throughput

0.479

High

696253

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

768928

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

937858

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

1033751

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1100264

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1106045

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

1137955

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

1197675

MIDN
Midnolin

1

3

High-throughput

0.479

High

1202223

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.479

High

1352697

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1364526

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

Small-scale

0.479

High

1367056

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1393604

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1399331

REN3B
Regulator of nonsense transcripts 3B

1

1

High-throughput

0.479

High

1399334

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

1399335

ANLN
Anillin

1

3

High-throughput

0.479

High

1399336

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

822821

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

474220

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

430249

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

896437

ERF
ETS domain-containing transcription factor ERF

1

3

High-throughput

0.445

High

1037322

H11
Histone H1.1

1

6

High-throughput

0.445

High

1130394

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

1399333

LN28A
Protein lin-28 homolog A

1

4

High-throughput

0.445

High

242632

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.437

High

363729

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.437

High

1290939

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.437

High

1397324

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1399332

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1399337

XPO7
Exportin-7

1

2

High-throughput

0.437

High

1399338

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

1315243

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.426

High

887135

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

58906

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

191759

MAGB2
Melanoma-associated antigen B2

1

7

High-throughput

0.407

High

391416

FRIL
Ferritin light chain

1

2

High-throughput

0.407

High

239177

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.313

High

618413

TSN8
Tetraspanin-8

1

0

High-throughput

0.279

Low

1178318

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

844958

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

1132414

CASP8
Caspase-8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025