Protein: REN3B
Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X)

Gene: REN3B, UPF3B
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q9BZI7

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1419947

RENT2
Regulator of nonsense transcripts 2

14

2

Small-scale

0.983

High

1370096

RENT1
Regulator of nonsense transcripts 1

14

2

Small-scale

0.761

High

1419967

RBM8A
RNA-binding protein 8A

9

4

Small-scale

0.748

High

807569

IF4A3
Eukaryotic initiation factor 4A-III

9

2

Small-scale

0.746

High

961105

MGN
Protein mago nashi homolog

6

1

Small-scale

0.721

High

183508

CASC3
Protein CASC3

5

2

Small-scale

0.713

High

1066771

NCBP1
Nuclear cap-binding protein subunit 1

1

1

Small-scale

0.691

High

1145353

RNPS1
RNA-binding protein with serine-rich domain 1

3

7

Small-scale

0.643

High

1400472

SMG1
Serine/threonine-protein kinase SMG1

2

1

Small-scale

0.611

High

1419944

REN3A
Regulator of nonsense transcripts 3A

2

1

Small-scale

0.602

High

1419954

NXF1
Nuclear RNA export factor 1

2

2

Small-scale

0.601

High

302948

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

4

High-throughput

0.584

High

346291

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

3

High-throughput

0.584

High

981071

H2B1C
Histone H2B type 1-C/E/F/G/I

2

1

High-throughput

0.584

High

1334884

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.584

High

941260

IF6
Eukaryotic translation initiation factor 6

2

0

High-throughput

0.561

High

1047099

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.546

High

948131

Z280A
Zinc finger protein 280A

1

1

High-throughput

0.536

High

998000

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1370353

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

1371856

CUL5
Cullin-5

1

3

High-throughput

0.536

High

1291190

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1327654

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

1419957

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.513

High

1390155

MCRS1
Microspherule protein 1

1

1

High-throughput

0.508

High

185994

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

1006686

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.501

High

1419951

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.493

High

1180863

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

1

High-throughput

0.489

High

157818

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

173320

XPO1
Exportin-1

1

3

High-throughput

0.479

High

256981

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

320040

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

373086

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

375916

RASK
GTPase KRas

1

5

High-throughput

0.479

High

401444

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

406612

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

459742

PROF1
Profilin-1

1

1

High-throughput

0.479

High

463747

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

473058

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.479

High

552874

TPR
Nucleoprotein TPR

1

4

High-throughput

0.479

High

658768

JAK1
Tyrosine-protein kinase JAK1

1

9

High-throughput

0.479

High

872720

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

900141

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.479

High

942862

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.479

High

956473

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

975223

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

978278

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.479

High

1024822

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1045735

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1108119

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1123806

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.479

High

1137506

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1138025

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

1138608

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1146805

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

1155732

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1207438

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

1215814

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1288977

EST1A
Telomerase-binding protein EST1A

1

2

Small-scale

0.479

High

1289603

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1360816

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

1382835

FUBP1
Far upstream element-binding protein 1

1

4

High-throughput

0.479

High

1393668

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1399331

NSUN5
28S rRNA

1

1

High-throughput

0.479

High

1403773

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

1419945

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1419948

RC3H2
Roquin-2

1

4

High-throughput

0.479

High

1419949

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1419950

TRI36
E3 ubiquitin-protein ligase TRIM36

1

3

High-throughput

0.479

High

1419953

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.479

High

1419955

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1419959

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1419962

TR150
Thyroid hormone receptor-associated protein 3

1

2

Small-scale

0.479

High

1419963

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

2

High-throughput

0.479

High

1419964

ARI1
E3 ubiquitin-protein ligase ARIH1

1

3

High-throughput

0.479

High

1419966

MAFB
Transcription factor MafB

1

2

High-throughput

0.479

High

1231792

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

1

High-throughput

0.464

High

340400

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

635141

ICAL
Calpastatin

1

0

High-throughput

0.458

High

644036

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

688138

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

703051

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

766826

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

876160

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.458

High

967548

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

975922

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

979212

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

982810

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

984964

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1040203

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.458

High

1135807

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1161653

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1368604

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1419952

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1419956

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

430335

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

485393

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

Small-scale

0.445

High

765862

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

1119293

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1290139

THOC4
THO complex subunit 4

1

5

Small-scale

0.445

High

1419960

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

Small-scale

0.445

High

1103028

CENPR
Centromere protein R

1

0

High-throughput

0.438

High

451444

NFM
Neurofilament medium polypeptide

1

4

High-throughput

0.437

High

1419958

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

1419961

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

1340197

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

1419946

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

887202

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

963127

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.279

Low

1030812

DEF5
Defensin alpha 5

1

0

High-throughput

0.279

Low

1309778

CCD60
Coiled-coil domain-containing protein 60

1

0

High-throughput

0.279

Low

1419965

FADS3
Fatty acid desaturase 3

1

0

High-throughput

0.279

Low

1143671

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.269

Low

1383665

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025