Protein: EXOS1
Exosome complex component CSL4 (Exosome component 1)

Gene: EXOS1, EXOSC1
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9Y3B2

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1447245

EXOS5
Exosome complex component RRP46

15

20

Small-scale

0.989

High

1384053

EXOS8
Exosome complex component RRP43

9

20

High-throughput

0.974

High

1447263

EXOS3
Exosome complex component RRP40

9

8

Small-scale

0.973

High

1446210

EXOS4
Exosome complex component RRP41

8

20

Small-scale

0.973

High

1137689

EXOS7
Exosome complex component RRP42

8

20

Small-scale

0.972

High

1209134

EXOS6
Exosome complex component MTR3

6

20

Small-scale

0.948

High

1118359

EXOS2
Exosome complex component RRP4

6

3

Small-scale

0.943

High

1054528

EXOS9
Exosome complex component RRP45

4

20

High-throughput

0.903

High

838813

MTREX
Exosome RNA helicase MTR4

2

9

High-throughput

0.789

High

1032273

EXOSX
Exosome complex component 10

7

8

Small-scale

0.745

High

1353563

DI3L1
DIS3-like exonuclease 1

5

10

Small-scale

0.723

High

1405178

MPH6
M-phase phosphoprotein 6

5

4

Small-scale

0.716

High

1491130

HBS1L
HBS1-like protein

4

1

Small-scale

0.696

High

1258864

KCTD1
BTB/POZ domain-containing protein KCTD1

3

1

High-throughput

0.675

High

1119085

C1D
Nuclear nucleic acid-binding protein C1D

3

1

High-throughput

0.675

High

1049069

REL
Proto-oncogene c-Rel

4

0

High-throughput

0.668

High

1240277

ZCHC8
Zinc finger CCHC domain-containing protein 8

3

1

High-throughput

0.667

High

1491131

RBM7
RNA-binding protein 7

3

2

High-throughput

0.667

High

1490743

MAST1
Microtubule-associated serine/threonine-protein kinase 1

2

4

High-throughput

0.633

High

970188

RS16
Small ribosomal subunit protein uS9

2

2

High-throughput

0.628

High

1432571

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

2

1

High-throughput

0.628

High

854962

RECQ1
ATP-dependent DNA helicase Q1

1

4

High-throughput

0.618

High

783769

ZNF76
Zinc finger protein 76

2

1

High-throughput

0.606

High

913912

ZN143
Zinc finger protein 143

2

1

High-throughput

0.606

High

1280145

PTAR1
Protein prenyltransferase alpha subunit repeat-containing protein 1

2

0

High-throughput

0.602

High

1400466

BTBD9
BTB/POZ domain-containing protein 9

2

0

High-throughput

0.602

High

587266

ITF2
Transcription factor 4

2

0

High-throughput

0.601

High

1348591

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

1386914

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1388037

ASB9
Ankyrin repeat and SOCS box protein 9

2

0

High-throughput

0.580

High

1454404

PAK5
Serine/threonine-protein kinase PAK 5

1

1

High-throughput

0.573

High

397285

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

1102387

GRB10
Growth factor receptor-bound protein 10

2

1

High-throughput

0.571

High

1372127

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.559

High

1397934

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

0

High-throughput

0.559

High

244796

ZC3H1
Zinc finger C3H1 domain-containing protein

1

3

High-throughput

0.536

High

278456

NCOR1
Nuclear receptor corepressor 1

1

3

High-throughput

0.536

High

849272

KSYK
Tyrosine-protein kinase SYK

1

2

High-throughput

0.536

High

859122

RL27A
Large ribosomal subunit protein uL15

1

2

High-throughput

0.536

High

884281

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

954321

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.536

High

969732

RS15A
Small ribosomal subunit protein uS8

1

1

High-throughput

0.536

High

977423

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.536

High

1051088

FAK1
Focal adhesion kinase 1

1

1

High-throughput

0.536

High

1085735

TBL3
Transducin beta-like protein 3

1

8

High-throughput

0.536

High

1144334

STK38
Serine/threonine-protein kinase 38

1

1

High-throughput

0.536

High

1341175

WDR36
WD repeat-containing protein 36

1

10

High-throughput

0.536

High

1399339

NSUN5
28S rRNA

1

2

High-throughput

0.536

High

1429086

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.536

High

1460371

BAZ1B
Tyrosine-protein kinase BAZ1B

1

1

High-throughput

0.536

High

1462454

SRPK3
SRSF protein kinase 3

1

1

High-throughput

0.536

High

1490812

RRP44
Exosome complex exonuclease RRP44

1

10

Small-scale

0.536

High

1158616

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.518

High

1347264

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.518

High

1410350

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.518

High

1429658

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

487907

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

627740

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.513

High

749170

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.513

High

769926

RFC2
Replication factor C subunit 2

1

0

High-throughput

0.513

High

983092

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.513

High

1136891

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.513

High

1384975

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.513

High

1437735

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.508

High

951915

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

1085309

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.486

High

974296

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

1

High-throughput

0.481

High

1206584

PRC2B
Protein PRRC2B

1

2

High-throughput

0.481

High

423505

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

252201

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

346540

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

473205

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

616061

RL17
Large ribosomal subunit protein uL22

1

3

High-throughput

0.479

High

914973

THOP1
Thimet oligopeptidase

1

1

High-throughput

0.479

High

937988

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

980583

H4
Histone H4

1

2

High-throughput

0.479

High

1151240

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.479

High

1227754

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

1251475

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

1290845

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.479

High

1352853

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1367656

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1368689

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

1393855

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1414721

MET22
Methyltransferase-like protein 22

1

1

High-throughput

0.479

High

1434299

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1454372

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

1459407

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1461929

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

713146

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.460

High

1116627

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.460

High

1150853

SF01
Splicing factor 1

1

0

High-throughput

0.460

High

1316493

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

1329145

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.460

High

1447960

SHLB2
Endophilin-B2

1

0

High-throughput

0.460

High

129582

MEN1
Menin

1

0

High-throughput

0.458

High

348007

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

971332

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1100570

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1116161

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

1128870

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.458

High

328201

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

373572

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.445

High

1412057

WDR83
WD repeat domain-containing protein 83

1

5

High-throughput

0.439

High

1112465

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

Small-scale

0.438

High

116292

H3BNT4
M-phase phosphoprotein 6

1

4

High-throughput

0.407

High

117107

J3QQT2
Large ribosomal subunit protein uL22

1

3

High-throughput

0.407

High

369789

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.282

High

1315010

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.251

Low

1126221

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1250338

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.238

Low

1288177

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025