Protein: HPSE
Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]

Gene: HPSE
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9Y251

Gene Ontology (top 5):
GO:0004566 - beta-glucuronidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1101447

SG2A2
Mammaglobin-A

2

1

High-throughput

0.628

High

1359278

CA054
Uncharacterized protein C1orf54

2

0

High-throughput

0.576

High

1358969

DNJA4
DnaJ homolog subfamily A member 4

2

3

High-throughput

0.574

High

286601

SG2A1
Mammaglobin-B

1

1

High-throughput

0.536

High

679291

DNJB1
DnaJ homolog subfamily B member 1

1

3

High-throughput

0.536

High

728020

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.536

High

731711

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.536

High

761936

HSP74
Heat shock 70 kDa protein 4

1

1

High-throughput

0.536

High

1365273

HS105
Heat shock protein 105 kDa

1

1

High-throughput

0.536

High

1438088

RC3H2
Roquin-2

1

1

High-throughput

0.536

High

1372346

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

131210

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.513

High

411123

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.513

High

518935

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

593542

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

879628

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.513

High

887611

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.513

High

931166

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.513

High

935816

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.513

High

1369088

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1416834

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

0

High-throughput

0.513

High

1461356

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1490494

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

1490495

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

259180

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.489

High

331429

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

1405915

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

1462273

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.479

High

1141057

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1490493

HPSE
Heparanase

1

0

Small-scale

0.458

High

116337

H3BS86
RING-type E3 ubiquitin transferase

1

2

High-throughput

0.445

High

117211

K7EIH8
DnaJ heat shock protein family

1

2

High-throughput

0.445

High

1358887

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

1

High-throughput

0.445

High

240169

FGF17
Fibroblast growth factor 17

1

0

High-throughput

0.426

High

288822

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.426

High

591398

CD44
CD44 antigen

1

0

High-throughput

0.426

High

616823

SDC1
Syndecan-1

1

0

High-throughput

0.426

High

652688

GNLY
Granulysin

1

0

High-throughput

0.426

High

658479

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.426

High

1037446

H11
Histone H1.1

1

0

High-throughput

0.426

High

1112228

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.426

High

1179396

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.426

High

1244342

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.426

High

1315267

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.426

High

1394905

EAF1
ELL-associated factor 1

1

0

High-throughput

0.426

High

1413892

ZN692
Zinc finger protein 692

1

0

High-throughput

0.426

High

1414021

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.426

High

1414248

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

0

High-throughput

0.426

High

1451833

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.426

High

1453902

H2AW
Core histone macro-H2A.2

1

0

High-throughput

0.426

High

61834

A4D110
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.407

High

1105591

OS9
Protein OS-9

2

0

High-throughput

0.328

High

1460867

FBX2
F-box only protein 2

2

0

High-throughput

0.313

High

325368

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

347423

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

733471

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

943162

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

1192011

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.279

Low

1334656

RETR2
Reticulophagy regulator 2

1

0

High-throughput

0.279

Low

1400837

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1409621

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

1459709

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

1202049

H90B2
Putative heat shock protein HSP 90-beta 2

1

0

High-throughput

0.232

Low

1234570

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.232

Low

1462398

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025