Protein: CNOT2
CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)

Gene: CNOT2
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q9NZN8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body
GO:0001222 - transcription corepressor binding
GO:0001829 - trophectodermal cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273942

CNOT3
CCR4-NOT transcription complex subunit 3

11

15

Small-scale

0.977

High

64140

CNOT1
CCR4-NOT transcription complex subunit 1

7

8

Small-scale

0.961

High

1453509

CNO11
CCR4-NOT transcription complex subunit 11

6

1

High-throughput

0.732

High

1453506

CNOT7
CCR4-NOT transcription complex subunit 7

6

10

High-throughput

0.730

High

1397045

CNO6L
CCR4-NOT transcription complex subunit 6-like

5

10

Small-scale

0.716

High

1436888

CNO10
CCR4-NOT transcription complex subunit 10

5

1

High-throughput

0.714

High

866846

CAZA2
F-actin-capping protein subunit alpha-2

4

3

High-throughput

0.691

High

1453503

CNOT8
CCR4-NOT transcription complex subunit 8

4

10

Small-scale

0.691

High

1365377

CNOT9
CCR4-NOT transcription complex subunit 9

4

7

High-throughput

0.686

High

1420822

TB182
182 kDa tankyrase-1-binding protein

4

8

Small-scale

0.683

High

1453511

CNOT6
CCR4-NOT transcription complex subunit 6

4

10

Small-scale

0.683

High

1215872

RC3H1
Roquin-1

4

5

Small-scale

0.676

High

1438631

GPBL1
Vasculin-like protein 1

3

1

High-throughput

0.667

High

897474

TOB1
Protein Tob1

3

3

Small-scale

0.662

High

1439104

TNR6C
Trinucleotide repeat-containing gene 6C protein

3

13

Small-scale

0.660

High

867468

CAPZB
F-actin-capping protein subunit beta

3

1

High-throughput

0.650

High

1438055

RC3H2
Roquin-2

3

10

Small-scale

0.640

High

1325726

RIBC1
RIB43A-like with coiled-coils protein 1

4

1

High-throughput

0.630

High

275464

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

1

High-throughput

0.628

High

949506

NANO2
Nanos homolog 2

2

7

High-throughput

0.628

High

1123153

FHL2
Four and a half LIM domains protein 2

2

4

High-throughput

0.628

High

1326450

MINK1
Misshapen-like kinase 1

2

2

High-throughput

0.628

High

1453502

NLK
Serine/threonine-protein kinase NLK

2

1

High-throughput

0.628

High

1453515

FBW1A
F-box/WD repeat-containing protein 1A

2

1

High-throughput

0.628

High

340590

CNOT4
CCR4-NOT transcription complex subunit 4

2

3

Small-scale

0.624

High

173478

XPO1
Exportin-1

2

2

High-throughput

0.611

High

1364163

TM131
Transmembrane protein 131

2

5

High-throughput

0.611

High

1453501

WRP73
WD repeat-containing protein WRAP73

2

1

High-throughput

0.611

High

480391

MMP7
Matrilysin

3

1

High-throughput

0.609

High

1219899

OBI1
ORC ubiquitin ligase 1

3

1

Small-scale

0.606

High

750488

CSTF2
Cleavage stimulation factor subunit 2

2

3

High-throughput

0.606

High

993004

RACK1
Small ribosomal subunit protein RACK1

2

1

High-throughput

0.606

High

1098307

TBX2
T-box transcription factor TBX2

2

3

High-throughput

0.606

High

1155994

ZFHX3
Zinc finger homeobox protein 3

2

1

High-throughput

0.606

High

1350732

CCHCR
Coiled-coil alpha-helical rod protein 1

2

1

High-throughput

0.606

High

1385400

ARMC5
Armadillo repeat-containing protein 5

2

3

High-throughput

0.606

High

1336864

TNR6A
Trinucleotide repeat-containing gene 6A protein

2

11

Small-scale

0.601

High

1453508

AGO2
Protein argonaute-2

2

3

Small-scale

0.601

High

1453512

TNR6B
Trinucleotide repeat-containing gene 6B protein

2

9

Small-scale

0.601

High

1310663

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

1

High-throughput

0.584

High

269403

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

700964

PSB4
Proteasome subunit beta type-4

2

0

High-throughput

0.580

High

832822

BCL6
B-cell lymphoma 6 protein

2

0

High-throughput

0.580

High

1094429

CSN1
COP9 signalosome complex subunit 1

2

0

High-throughput

0.580

High

1329262

GCSAM
Germinal center-associated signaling and motility protein

2

0

High-throughput

0.580

High

1416789

TEKT3
Tektin-3

2

0

High-throughput

0.580

High

1434577

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.580

High

1438302

BEX1
Protein BEX1

2

0

High-throughput

0.580

High

1417395

TX13A
Testis-expressed protein 13A

2

1

High-throughput

0.574

High

397097

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

1399944

FACOS
FANCD2 opposite strand protein

2

1

High-throughput

0.549

High

64814

EPAB2
Embryonic polyadenylate-binding protein 2

1

4

High-throughput

0.536

High

302089

SEGN
Secretagogin

1

1

High-throughput

0.536

High

844039

HD
Huntingtin

1

1

High-throughput

0.536

High

848735

MAGA9
Melanoma-associated antigen 9

1

3

High-throughput

0.536

High

915205

CAZA1
F-actin-capping protein subunit alpha-1

1

3

High-throughput

0.536

High

1052111

CALD1
Caldesmon

1

3

High-throughput

0.536

High

1245752

LARP1
La-related protein 1

1

4

High-throughput

0.536

High

1347604

UHMK1
Serine/threonine-protein kinase Kist

1

2

High-throughput

0.536

High

1360510

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1361407

NANO1
Nanos homolog 1

1

7

High-throughput

0.536

High

1435382

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1435666

WDR26
WD repeat-containing protein 26

1

2

High-throughput

0.536

High

1453514

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

1

High-throughput

0.536

High

1157971

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.518

High

188377

HDAC3
Histone deacetylase 3

1

1

Small-scale

0.515

High

398011

KLKB1
Plasma kallikrein

1

0

High-throughput

0.513

High

703077

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

716984

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.513

High

928820

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

0

High-throughput

0.513

High

941287

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

970146

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1243434

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

0

High-throughput

0.513

High

1310479

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1367909

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

1370144

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.513

High

1390486

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.513

High

1395301

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1453500

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.513

High

1160961

PDK4
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

1453505

S18L2
SS18-like protein 2

1

1

High-throughput

0.489

High

1098602

GPS2
G protein pathway suppressor 2

1

0

Small-scale

0.486

High

278439

NCOR1
Nuclear receptor corepressor 1

1

8

Small-scale

0.481

High

1453520

NCOR2
Nuclear receptor corepressor 2

1

5

Small-scale

0.481

High

170390

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

175241

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.479

High

176562

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

274252

ANR17
Ankyrin repeat domain-containing protein 17

1

3

High-throughput

0.479

High

281440

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.479

High

538026

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

589897

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

607169

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

613208

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

626383

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

7

High-throughput

0.479

High

684417

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.479

High

688330

TTP
mRNA decay activator protein ZFP36

1

5

High-throughput

0.479

High

713866

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

4

High-throughput

0.479

High

728001

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.479

High

765073

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

769374

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

875811

PRC2A
Protein PRRC2A

1

7

High-throughput

0.479

High

900537

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.479

High

935206

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

954294

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

1096841

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

1101067

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

1116070

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

1122184

UBP2L
Ubiquitin-associated protein 2-like

1

6

High-throughput

0.479

High

1129526

PUM1
Pumilio homolog 1

1

7

High-throughput

0.479

High

1149759

SSXT
Protein SSXT

1

5

High-throughput

0.479

High

1165518

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

7

High-throughput

0.479

High

1208593

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.479

High

1213554

UBAP2
Ubiquitin-associated protein 2

1

9

High-throughput

0.479

High

1241600

CEP85
Centrosomal protein of 85 kDa

1

4

High-throughput

0.479

High

1252406

MEX3B
RNA-binding protein MEX3B

1

3

High-throughput

0.479

High

1280760

YTHD3
YTH domain-containing family protein 3

1

8

High-throughput

0.479

High

1287140

PATL1
Protein PAT1 homolog 1

1

9

High-throughput

0.479

High

1311419

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.479

High

1314164

RAVR1
Ribonucleoprotein PTB-binding 1

1

5

High-throughput

0.479

High

1327737

MACOI
Macoilin

1

1

High-throughput

0.479

High

1335015

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1336316

LS14A
Protein LSM14 homolog A

1

4

High-throughput

0.479

High

1348137

PUM2
Pumilio homolog 2

1

8

High-throughput

0.479

High

1350192

ALMS1
Centrosome-associated protein ALMS1

1

4

High-throughput

0.479

High

1363998

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1367446

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1368159

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1393973

FUBP3
Far upstream element-binding protein 3

1

1

High-throughput

0.479

High

1418749

YTHD1
YTH domain-containing family protein 1

1

8

High-throughput

0.479

High

1419548

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

High-throughput

0.479

High

1420674

UNK
RING finger protein unkempt homolog

1

5

High-throughput

0.479

High

1428565

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.479

High

1435694

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

1437070

AGO3
Protein argonaute-3

1

4

High-throughput

0.479

High

1446699

AKIP1
A-kinase-interacting protein 1

1

1

High-throughput

0.479

High

1448113

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

1451632

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.479

High

1453504

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1453510

AGO1
Protein argonaute-1

1

4

High-throughput

0.479

High

1453513

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

3

High-throughput

0.479

High

1453516

R3HD2
R3H domain-containing protein 2

1

7

High-throughput

0.479

High

1453517

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.479

High

1453518

PRC2C
Protein PRRC2C

1

11

High-throughput

0.479

High

1453519

YTHD2
YTH domain-containing family protein 2

1

8

High-throughput

0.479

High

99212

F2Z2M7
Polypeptide N-acetylgalactosaminyltransferase 10

1

1

High-throughput

0.470

High

129497

MEN1
Menin

1

0

High-throughput

0.458

High

252181

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

352574

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

441515

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.458

High

787260

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

831552

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

981720

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.458

High

1108225

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1151464

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.458

High

1289201

N4BP2
NEDD4-binding protein 2

1

0

High-throughput

0.458

High

1339209

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1382893

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.458

High

1448505

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

114496

H0YCH8
A-kinase interacting protein 1

1

1

High-throughput

0.445

High

1453507

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.445

High

1286623

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

1

High-throughput

0.439

High

1206561

PRC2B
Protein PRRC2B

1

6

High-throughput

0.437

High

1336222

RN214
RING finger protein 214

1

1

High-throughput

0.437

High

1385707

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

1395548

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

108088

G3V529
ATP-dependent RNA helicase

1

2

High-throughput

0.407

High

506774

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1429331

MFR1L
Mitochondrial fission regulator 1-like

2

0

High-throughput

0.316

High

1431184

CMIP1
Ciliary microtubule inner protein 1

2

0

High-throughput

0.316

High

183758

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.279

Low

1438518

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.279

Low

1004297

F193A
Protein FAM193A

1

0

High-throughput

0.249

Low

1366098

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.249

Low

1432594

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.249

Low

1435094

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.249

Low

1439174

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

947068

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025