Protein: MKLN1
Muskelin

Gene: MKLN1
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q9UL63

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001726 - ruffle
GO:0002090 - regulation of receptor internalization
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1461468

MKLN1
Muskelin

3

19

Small-scale

0.843

High

1402343

RANB9
Ran-binding protein 9

8

6

Small-scale

0.753

High

1436205

RMD5A
E3 ubiquitin-protein transferase RMND5A

6

8

Small-scale

0.733

High

1451499

GID8
Glucose-induced degradation protein 8 homolog

4

10

Small-scale

0.696

High

1307952

ARMC8
Armadillo repeat-containing protein 8

4

3

High-throughput

0.691

High

1272759

MAEA
E3 ubiquitin-protein transferase MAEA

4

10

Small-scale

0.689

High

1104698

IKZF1
DNA-binding protein Ikaros

3

2

High-throughput

0.662

High

1435673

WDR26
WD repeat-containing protein 26

3

11

Small-scale

0.656

High

1388514

ZMY19
Zinc finger MYND domain-containing protein 19

3

0

High-throughput

0.634

High

561397

TDGF1
Protein Cripto

4

1

High-throughput

0.630

High

568015

PRG2
Bone marrow proteoglycan

4

1

High-throughput

0.630

High

1194801

GRPL2
GLIPR1-like protein 2

4

1

High-throughput

0.630

High

340951

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

2

7

High-throughput

0.628

High

1250536

RBP10
Ran-binding protein 10

2

6

High-throughput

0.611

High

480395

MMP7
Matrilysin

3

1

High-throughput

0.609

High

1369086

GGH
Gamma-glutamyl hydrolase

3

1

High-throughput

0.609

High

1329003

ZBTB2
Zinc finger and BTB domain-containing protein 2

2

3

High-throughput

0.606

High

1393015

CC120
Coiled-coil domain-containing protein 120

3

2

High-throughput

0.604

High

1461469

PRG3
Proteoglycan 3

3

1

High-throughput

0.604

High

1461472

INSL6
Insulin-like peptide INSL6

3

1

High-throughput

0.604

High

1447790

DBLOH
Diablo IAP-binding mitochondrial protein

2

1

High-throughput

0.601

High

1449498

EMIL3
EMILIN-3

2

12

High-throughput

0.601

High

1098609

GPS2
G protein pathway suppressor 2

2

0

High-throughput

0.585

High

1309323

GID4
Glucose-induced degradation protein 4 homolog

2

0

Small-scale

0.585

High

1416261

CYREN
Cell cycle regulator of non-homologous end joining

2

0

High-throughput

0.580

High

562771

BMP1
Bone morphogenetic protein 1

2

2

High-throughput

0.574

High

1340136

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

2

3

High-throughput

0.574

High

1454818

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

2

High-throughput

0.574

High

1460046

TCAL9
Transcription elongation factor A protein-like 9

2

1

High-throughput

0.549

High

219245

LTOR5
Ragulator complex protein LAMTOR5

1

1

High-throughput

0.541

High

216849

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.536

High

253461

CST8
Cystatin-8

1

1

High-throughput

0.536

High

505901

R10B1
Radial spoke head 10 homolog B

1

1

High-throughput

0.536

High

786300

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.536

High

872876

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.536

High

928236

HAP1
Huntingtin-associated protein 1

1

8

High-throughput

0.536

High

1116788

AAMP
Angio-associated migratory cell protein

1

7

High-throughput

0.536

High

1124086

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.536

High

1250860

CRDL2
Chordin-like protein 2

1

2

High-throughput

0.536

High

1335258

KCTD6
BTB/POZ domain-containing protein KCTD6

1

4

High-throughput

0.536

High

1349244

PMFBP
Polyamine-modulated factor 1-binding protein 1

1

12

High-throughput

0.536

High

1408517

GDF15
Growth/differentiation factor 15

1

1

High-throughput

0.536

High

1409967

DDX50
ATP-dependent RNA helicase DDX50

1

1

High-throughput

0.536

High

615203

PACA
Pituitary adenylate cyclase-activating polypeptide

2

2

High-throughput

0.521

High

1121659

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.518

High

373464

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.515

High

1145433

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.515

High

1383162

LRC59
Leucine-rich repeat-containing protein 59

1

6

High-throughput

0.515

High

169321

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.513

High

270285

MTG16
Protein CBFA2T3

1

0

High-throughput

0.513

High

376924

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.513

High

477349

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.513

High

555439

SKI
Ski oncogene

1

0

High-throughput

0.513

High

1179882

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.513

High

1389033

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1432705

MMAD
Cobalamin trafficking protein CblD

1

0

High-throughput

0.513

High

139087

LAD1
Ladinin-1

1

2

High-throughput

0.489

High

652687

GNLY
Granulysin

1

2

High-throughput

0.489

High

852319

MMP13
Collagenase 3

1

1

High-throughput

0.489

High

933245

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.489

High

1395089

JPH4
Junctophilin-4

1

1

High-throughput

0.489

High

1414013

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

1417808

ANGL4
Angiopoietin-related protein 4

1

1

High-throughput

0.489

High

1428803

WN10A
Protein Wnt-10a

1

3

High-throughput

0.489

High

1438805

SPON1
Spondin-1

1

1

High-throughput

0.489

High

1453407

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.489

High

1459927

IL17B
Interleukin-17B

1

2

High-throughput

0.489

High

1459972

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

3

High-throughput

0.489

High

1461426

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

159913

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

9

High-throughput

0.479

High

248369

HBP1
HMG box-containing protein 1

1

7

High-throughput

0.479

High

294517

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

358827

LDHA
L-lactate dehydrogenase A chain

1

1

Small-scale

0.479

High

573277

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.479

High

590009

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

814927

GDNF
Glial cell line-derived neurotrophic factor

1

1

High-throughput

0.479

High

971274

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

977169

YPEL5
Protein yippee-like 5

1

1

High-throughput

0.479

High

1048183

TLE4
Transducin-like enhancer protein 4

1

11

High-throughput

0.479

High

1095518

NR1H3
Oxysterols receptor LXR-alpha

1

10

High-throughput

0.479

High

1100525

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

1135166

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1256053

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

1358140

NUDC2
NudC domain-containing protein 2

1

20

High-throughput

0.479

High

1360252

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

1

High-throughput

0.479

High

1391447

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

8

High-throughput

0.479

High

1435438

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1458539

HDAC6
Protein deacetylase HDAC6

1

6

Small-scale

0.479

High

561158

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.458

High

956024

RAB8A
Ras-related protein Rab-8A

1

0

High-throughput

0.458

High

131528

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

11

High-throughput

0.445

High

639179

SYT1
Synaptotagmin-1

1

4

High-throughput

0.445

High

1029170

E2F1
Transcription factor E2F1

1

4

High-throughput

0.445

High

1030823

DEF5
Defensin alpha 5

1

1

High-throughput

0.445

High

1314478

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.445

High

1432380

PININ
Pinin

1

1

High-throughput

0.445

High

72989

WDR64
WD repeat-containing protein 64

1

13

High-throughput

0.437

High

941602

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.437

High

1243906

SG11A
Sperm-associated antigen 11A

1

1

High-throughput

0.437

High

63788

KRBA1
Protein KRBA1

1

1

High-throughput

0.407

High

1064643

SG11B
Sperm-associated antigen 11B

1

1

High-throughput

0.407

High

1206458

Q5JSZ1
TLE family member 4, transcriptional corepressor

1

2

High-throughput

0.407

High

1324287

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.407

High

1331878

SYT2
Synaptotagmin-2

1

4

High-throughput

0.407

High

1416820

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

9

High-throughput

0.407

High

1393187

SFRP2
Secreted frizzled-related protein 2

4

0

High-throughput

0.360

High

409624

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

3

0

High-throughput

0.347

High

1418281

RM04
Large ribosomal subunit protein uL4m

3

0

High-throughput

0.347

High

1380564

PIGT
GPI-anchor transamidase component PIGT

3

0

High-throughput

0.345

High

1198328

TIGD5
Tigger transposable element-derived protein 5

2

0

High-throughput

0.328

High

1451570

HPF1
Histone PARylation factor 1

2

0

High-throughput

0.319

High

377298

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

2

0

High-throughput

0.313

High

275789

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.279

Low

278776

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.279

Low

316702

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.279

Low

774009

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

1309558

NNRD
ATP-dependent

1

0

High-throughput

0.279

Low

1341069

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

1389236

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.279

Low

1430530

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low

1435554

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

1460231

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

1461470

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.279

Low

1461471

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

0

High-throughput

0.279

Low

845493

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

0

Small-scale

0.275

Low

1418512

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1133815

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.232

Low

1401823

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.232

Low

1402431

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025