Protein: ARHG4
Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1)

Gene: ARHG4, ARHGEF4
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q9NR80

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0019904 - protein domain specific binding
GO:0030032 - lamellipodium assembly
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925649

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.800

High

894480

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.778

High

900947

RHOA
Transforming protein RhoA

2

20

Small-scale

0.778

High

626260

APC
Adenomatous polyposis coli protein

4

6

Small-scale

0.703

High

63612

ASB14
Ankyrin repeat and SOCS box protein 14

1

5

High-throughput

0.691

High

1164152

WDR74
WD repeat-containing protein 74

2

8

High-throughput

0.659

High

905155

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

982535

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

341467

FA12
Coagulation factor XII

1

2

High-throughput

0.618

High

1223881

AN13A
Ankyrin repeat domain-containing protein 13A

1

5

High-throughput

0.618

High

387581

P53
Cellular tumor antigen p53

1

3

High-throughput

0.618

High

1298561

SPT13
Spermatogenesis-associated protein 13

1

16

Small-scale

0.618

High

647309

1433T
14-3-3 protein theta

2

20

High-throughput

0.611

High

910068

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.611

High

927568

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

253201

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

1079610

NEDD8
NEDD8

1

2

Small-scale

0.575

High

1244718

NUP35
Nucleoporin NUP35

2

1

High-throughput

0.571

High

1344362

SLAI2
SLAIN motif-containing protein 2

2

1

High-throughput

0.571

High

881036

IF6
Eukaryotic translation initiation factor 6

2

0

High-throughput

0.547

High

1327491

BTBD1
BTB/POZ domain-containing protein 1

1

4

High-throughput

0.536

High

1092630

KNOP1
Lysine-rich nucleolar protein 1

2

1

High-throughput

0.521

High

1294261

FUBP3
Far upstream element-binding protein 3

2

5

High-throughput

0.521

High

1306822

EBP2
Probable rRNA-processing protein EBP2

2

1

High-throughput

0.521

High

1344360

RBM22
Pre-mRNA-splicing factor RBM22

2

4

High-throughput

0.521

High

277361

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

430430

PMGE
Bisphosphoglycerate mutase

1

0

High-throughput

0.513

High

1332115

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

299023

TMCC1
Transmembrane and coiled-coil domains protein 1

1

0

High-throughput

0.493

High

1100153

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

451574

CLCA
Clathrin light chain A

1

5

High-throughput

0.479

High

614437

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.479

High

683745

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

911058

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.479

High

911977

RUXF
Small nuclear ribonucleoprotein F

1

3

High-throughput

0.479

High

1057402

SMC1A
Structural maintenance of chromosomes protein 1A

1

5

High-throughput

0.479

High

1068677

PLEC
Plectin

1

12

High-throughput

0.479

High

1259872

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

4

High-throughput

0.479

High

1344363

TPX2
Targeting protein for Xklp2

1

5

High-throughput

0.479

High

1344365

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.479

High

958529

CYC
Cytochrome c

1

0

High-throughput

0.458

High

152338

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

7

Small-scale

0.457

High

1344358

DISC1
Disrupted in schizophrenia 1 protein

1

7

High-throughput

0.457

High

1344359

EXOC1
Exocyst complex component 1

1

3

High-throughput

0.457

High

500893

CLUS
Clusterin

1

0

High-throughput

0.438

High

279728

FLOT1
Flotillin-1

1

8

High-throughput

0.437

High

300268

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.437

High

328662

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.437

High

839691

SERPH
Serpin H1

1

5

High-throughput

0.437

High

1162385

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

1

High-throughput

0.437

High

1332274

CCD86
Coiled-coil domain-containing protein 86

1

3

High-throughput

0.437

High

1344361

MIC19
MICOS complex subunit MIC19

1

2

High-throughput

0.437

High

354573

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.417

High

991896

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

7

Small-scale

0.408

High

1078361

MLF2
Myeloid leukemia factor 2

2

0

High-throughput

0.298

High

1232970

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1344364

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

1128029

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.249

Low

1318606

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024