Protein: TRI74
Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C)

Gene: TRI74, TRIM74
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q86UV6

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0045087 - innate immune response
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

799256

BRCA1
Breast cancer type 1 susceptibility protein

1

17

High-throughput

0.698

High

1289124

RNF32
RING finger protein 32

1

0

High-throughput

0.663

High

1289118

DTBP1
Dysbindin

3

2

High-throughput

0.657

High

1218725

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

1048899

REL
Proto-oncogene c-Rel

1

5

High-throughput

0.573

High

983866

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.541

High

1248425

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

4

High-throughput

0.541

High

1289121

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.541

High

1243706

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

18

High-throughput

0.536

High

244477

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.518

High

169625

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

High-throughput

0.515

High

300399

KRT34
Keratin, type I cuticular Ha4

1

16

High-throughput

0.515

High

904889

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.515

High

927387

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

1044669

ARI5A
AT-rich interactive domain-containing protein 5A

1

6

High-throughput

0.515

High

1123023

FHL2
Four and a half LIM domains protein 2

1

6

High-throughput

0.515

High

1218925

TASO2
Protein TASOR 2

1

3

High-throughput

0.515

High

1279598

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

7

High-throughput

0.515

High

1289113

PNMA1
Paraneoplastic antigen Ma1

1

5

High-throughput

0.515

High

1289115

PSMF1
Proteasome inhibitor PI31 subunit

1

1

High-throughput

0.515

High

1289117

DDT4L
DNA damage-inducible transcript 4-like protein

1

2

High-throughput

0.515

High

1289119

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

4

High-throughput

0.515

High

1289120

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.515

High

1289122

RUSC1
AP-4 complex accessory subunit RUSC1

1

1

High-throughput

0.515

High

1289123

BEX2
Protein BEX2

1

3

High-throughput

0.515

High

1289116

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.513

High

165771

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.493

High

288453

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.481

High

1289114

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

20

High-throughput

0.481

High

1289125

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

High-throughput

0.481

High

461658

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.479

High

468554

HS90B
Heat shock protein HSP 90-beta

1

19

High-throughput

0.479

High

217137

MS18B
Protein Mis18-beta

1

1

High-throughput

0.470

High

506746

PRR35
Proline-rich protein 35

1

2

High-throughput

0.470

High

622203

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.470

High

992430

GBG3

1

2

High-throughput

0.470

High

1007945

PO6F2
POU domain, class 6, transcription factor 2

1

6

High-throughput

0.470

High

1096080

TADBP
TAR DNA-binding protein 43

1

15

High-throughput

0.470

High

1220010

TTC23
Tetratricopeptide repeat protein 23

1

3

High-throughput

0.470

High

64055

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

653414

HEMH
Ferrochelatase, mitochondrial

2

0

High-throughput

0.318

High

907158

SUOX
Sulfite oxidase, mitochondrial

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025