Protein: IZUM1
Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo)

Gene: IZUM1, IZUMO1
Organism: Homo sapiens
Interactions: 34
UniProt ID: Q8IYV9

Gene Ontology (top 5):
GO:0000768 - syncytium formation by plasma membrane fusion
GO:0001669 - acrosomal vesicle
GO:0002080 - acrosomal membrane
GO:0005102 - signaling receptor binding
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

64645

JUNO
Sperm-egg fusion protein Juno

2

0

Small-scale

0.798

High

1315613

IZUM1
Izumo sperm-egg fusion protein 1

1

0

Small-scale

0.657

High

1315615

S39AB
Zinc transporter ZIP11

3

0

High-throughput

0.634

High

1315625

GHITM
Growth hormone-inducible transmembrane protein

3

0

High-throughput

0.634

High

658906

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

1

High-throughput

0.628

High

1256341

AN13D
Ankyrin repeat domain-containing protein 13D

2

1

High-throughput

0.628

High

1315614

AN13A
Ankyrin repeat domain-containing protein 13A

2

1

High-throughput

0.628

High

1315628

CNOT6
CCR4-NOT transcription complex subunit 6

2

1

High-throughput

0.611

High

243809

ADCY3
Adenylate cyclase type 3

2

0

High-throughput

0.602

High

1116823

AVR2B
Activin receptor type-2B

2

0

High-throughput

0.602

High

1315619

CNOT9
CCR4-NOT transcription complex subunit 9

2

0

High-throughput

0.602

High

1315620

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

2

0

High-throughput

0.602

High

1315621

LRAT2
Protein LRATD2

2

0

High-throughput

0.602

High

1315623

EFC4B
EF-hand calcium-binding domain-containing protein 4B

2

0

High-throughput

0.602

High

1315629

S4A7
Sodium bicarbonate cotransporter 3

2

0

High-throughput

0.602

High

522696

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

1

High-throughput

0.536

High

1062994

DDR1
Epithelial discoidin domain-containing receptor 1

1

2

High-throughput

0.536

High

64061

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

541581

FGFR1
Fibroblast growth factor receptor 1

1

0

High-throughput

0.513

High

557374

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

1116942

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

1

0

High-throughput

0.513

High

1233985

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

1

0

High-throughput

0.513

High

1315616

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.513

High

1315618

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.513

High

1315626

TMX1
Thioredoxin-related transmembrane protein 1

1

0

High-throughput

0.513

High

1243149

TMM81
Transmembrane protein 81

1

0

Small-scale

0.458

High

719983

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.426

High

94350

D6R9H6
CCR4-NOT transcription complex subunit 6

1

1

High-throughput

0.407

High

1093002

CDC16
Cell division cycle protein 16 homolog

3

0

High-throughput

0.345

High

1315627

CNO11
CCR4-NOT transcription complex subunit 11

2

0

High-throughput

0.328

High

1315617

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.279

Low

1315624

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.279

Low

1315622

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025