Protein: CBX4
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)

Gene: CBX4
Organism: Homo sapiens
Interactions: 222
UniProt ID: O00257

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0003727 - single-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

123193

BMI1
Polycomb complex protein BMI-1

17

20

Small-scale

0.985

High

123243

RING1
E3 ubiquitin-protein ligase RING1

10

20

Small-scale

0.976

High

123308

RING2
E3 ubiquitin-protein ligase RING2

8

20

Small-scale

0.973

High

123194

PCGF2
Polycomb group RING finger protein 2

9

20

Small-scale

0.970

High

123325

CBX8
Chromobox protein homolog 8

5

16

Small-scale

0.922

High

123317

PCGF6
Polycomb group RING finger protein 6

4

20

High-throughput

0.909

High

123249

CBX2
Chromobox protein homolog 2

4

17

Small-scale

0.873

High

123312

PCGF1
Polycomb group RING finger protein 1

3

20

Small-scale

0.861

High

123257

PCGF3
Polycomb group RING finger protein 3

3

20

High-throughput

0.847

High

123140

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

20

Small-scale

0.844

High

123337

KDM5B
Lysine-specific demethylase 5B

2

4

Small-scale

0.806

High

123136

CBX4
E3 SUMO-protein ligase CBX4

2

16

Small-scale

0.802

High

123153

CBX6
Chromobox protein homolog 6

2

17

High-throughput

0.789

High

123273

PCGF5
Polycomb group RING finger protein 5

2

20

High-throughput

0.789

High

123234

PHC1
Polyhomeotic-like protein 1

10

20

Small-scale

0.754

High

123246

CTBP1
C-terminal-binding protein 1

9

5

Small-scale

0.751

High

123280

PHC2
Polyhomeotic-like protein 2

6

20

Small-scale

0.735

High

123290

PHC3
Polyhomeotic-like protein 3

6

20

Small-scale

0.729

High

123351

DNM3A
DNA

1

9

Small-scale

0.724

High

123242

1433F
14-3-3 protein eta

5

8

High-throughput

0.709

High

123327

HELLS
Lymphoid-specific helicase

1

20

High-throughput

0.691

High

123184

1433T
14-3-3 protein theta

4

8

High-throughput

0.691

High

123229

CSK2B
Casein kinase II subunit beta

3

4

Small-scale

0.674

High

123230

CSK21
Casein kinase II subunit alpha

3

10

Small-scale

0.671

High

123175

CSK22
Casein kinase II subunit alpha'

3

10

Small-scale

0.667

High

123268

BCOR
BCL-6 corepressor

3

20

Small-scale

0.667

High

123189

1433B
14-3-3 protein beta/alpha

3

8

Small-scale

0.660

High

123236

H33
Histone H3.3

3

20

Small-scale

0.650

High

123218

1433G
14-3-3 protein gamma

5

8

High-throughput

0.648

High

123240

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.647

High

123245

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

Small-scale

0.647

High

123299

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

9

Small-scale

0.640

High

123226

1433Z
14-3-3 protein zeta/delta

2

8

High-throughput

0.621

High

123227

SUMO1
Small ubiquitin-related modifier 1

2

4

Small-scale

0.611

High

123303

SCMH1
Polycomb protein SCMH1

2

20

High-throughput

0.611

High

123288

KCD17
BTB/POZ domain-containing protein KCTD17

3

3

High-throughput

0.609

High

63824

ARI3C
AT-rich interactive domain-containing protein 3C

2

4

High-throughput

0.606

High

123174

RO52
E3 ubiquitin-protein ligase TRIM21

2

6

High-throughput

0.606

High

123147

PR40A
Pre-mRNA-processing factor 40 homolog A

2

1

High-throughput

0.601

High

123231

H31
Histone H3.1

2

20

Small-scale

0.601

High

123253

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.597

High

123237

SATB1
DNA-binding protein SATB1

2

1

Small-scale

0.595

High

123219

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.595

High

123146

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

123166

RB
Retinoblastoma-associated protein

2

10

Small-scale

0.584

High

123207

ZN131
Zinc finger protein 131

2

20

Small-scale

0.584

High

123221

H4
Histone H4

2

15

High-throughput

0.584

High

123233

GTF2I
General transcription factor II-I

2

2

Small-scale

0.584

High

123251

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

123258

DCAF6
DDB1- and CUL4-associated factor 6

2

14

High-throughput

0.584

High

123283

SLX4
Structure-specific endonuclease subunit SLX4

2

8

High-throughput

0.584

High

123143

ZEB2
Zinc finger E-box-binding homeobox 2

1

20

Small-scale

0.578

High

123241

ERCC6
DNA excision repair protein ERCC-6

1

20

High-throughput

0.575

High

123332

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

High-throughput

0.575

High

123256

KLH40
Kelch-like protein 40

2

4

High-throughput

0.574

High

123300

VWCE
von Willebrand factor C and EGF domain-containing protein

2

4

High-throughput

0.574

High

123254

H31T
Histone H3.1t

2

20

Small-scale

0.571

High

123157

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

123190

1433S
14-3-3 protein sigma

2

8

High-throughput

0.571

High

123339

MBD1
Methyl-CpG-binding domain protein 1

1

20

Small-scale

0.561

High

123324

FBRS
Probable fibrosin-1

2

6

High-throughput

0.558

High

123212

CTBP2
C-terminal-binding protein 2

1

5

Small-scale

0.552

High

123155

WIZ
Protein Wiz

1

20

High-throughput

0.536

High

123178

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

123201

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.536

High

123208

TXTP
Tricarboxylate transport protein, mitochondrial

1

7

High-throughput

0.536

High

123216

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.536

High

123228

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.536

High

123244

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

123255

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

123276

TSYL5
Testis-specific Y-encoded-like protein 5

1

3

High-throughput

0.536

High

123278

KMT5C
Histone-lysine N-methyltransferase KMT5C

1

3

High-throughput

0.536

High

123291

KDM2B
Lysine-specific demethylase 2B

1

10

High-throughput

0.536

High

123311

TBA1C
Tubulin alpha-1C chain

1

9

High-throughput

0.536

High

123342

SCML1
Sex comb on midleg-like protein 1

1

20

High-throughput

0.536

High

123348

KDM2A
Lysine-specific demethylase 2A

1

13

High-throughput

0.536

High

123162

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.515

High

123269

H32
Histone H3.2

1

20

Small-scale

0.515

High

123171

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

123223

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.515

High

123144

CCNT1
Cyclin-T1

1

0

High-throughput

0.513

High

123145

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.513

High

123179

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.513

High

123261

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.513

High

123301

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

123334

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

123321

KDM4C
Lysine-specific demethylase 4C

1

9

Small-scale

0.501

High

123137

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.493

High

123186

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

123210

CASP6
Caspase-6

1

0

High-throughput

0.493

High

119694

AP4M1
AP-4 complex subunit mu-1

1

1

High-throughput

0.489

High

123180

LAMA1
Laminin subunit alpha-1

1

1

High-throughput

0.489

High

123213

MYL6
Myosin light polypeptide 6

1

1

High-throughput

0.489

High

123260

CD158
Coiled-coil domain-containing protein 158

1

2

High-throughput

0.489

High

123305

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

1

High-throughput

0.489

High

123335

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

123338

S18L2
SS18-like protein 2

1

1

High-throughput

0.489

High

123340

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

123350

PCDBB
Protocadherin beta-11

1

11

High-throughput

0.489

High

123170

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

123142

SPOP
Speckle-type POZ protein

1

5

Small-scale

0.481

High

123156

ZBED1
E3 SUMO-protein ligase ZBED1

1

1

Small-scale

0.481

High

123176

MX1
Interferon-induced GTP-binding protein Mx1

1

1

Small-scale

0.481

High

123298

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

123139

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

5

High-throughput

0.479

High

123148

EED
Polycomb protein EED

1

17

High-throughput

0.479

High

123149

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

3

High-throughput

0.479

High

123152

TOX4
TOX high mobility group box family member 4

1

18

High-throughput

0.479

High

123154

EYA4
Eyes absent homolog 4

1

7

High-throughput

0.479

High

123158

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

123159

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

123160

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.479

High

123163

JUN
Transcription factor Jun

1

9

High-throughput

0.479

High

123167

NPM
Nucleophosmin

1

3

High-throughput

0.479

High

123168

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

123169

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.479

High

123173

EGR1
Early growth response protein 1

1

20

High-throughput

0.479

High

123181

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

123182

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

123183

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

123187

PML
Protein PML

1

20

High-throughput

0.479

High

123191

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

123196

SYUA
Alpha-synuclein

1

1

Small-scale

0.479

High

123197

COIL
Coilin

1

2

High-throughput

0.479

High

123198

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

123200

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.479

High

123202

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.479

High

123204

RBM25
RNA-binding protein 25

1

5

High-throughput

0.479

High

123205

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

123206

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

14

Small-scale

0.479

High

123209

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

123211

SUMO3
Small ubiquitin-related modifier 3

1

4

Small-scale

0.479

High

123214

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.479

High

123215

SUMO2
Small ubiquitin-related modifier 2

1

4

Small-scale

0.479

High

123217

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

7

Small-scale

0.479

High

123220

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

123222

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

123224

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

123225

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

123232

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

123238

CENPE
Centromere-associated protein E

1

2

High-throughput

0.479

High

123247

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.479

High

123250

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

123252

NONO
Non-POU domain-containing octamer-binding protein

1

5

High-throughput

0.479

High

123265

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

123267

WDR82
WD repeat-containing protein 82

1

17

High-throughput

0.479

High

123271

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.479

High

123277

DDX42
ATP-dependent RNA helicase DDX42

1

3

High-throughput

0.479

High

123279

MGAP
MAX gene-associated protein

1

9

High-throughput

0.479

High

123281

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

123282

YAF2
YY1-associated factor 2

1

12

High-throughput

0.479

High

123285

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

15

Small-scale

0.479

High

123287

RYBP
RING1 and YY1-binding protein

1

12

High-throughput

0.479

High

123289

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.479

High

123294

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

3

High-throughput

0.479

High

123295

ATX2L
Ataxin-2-like protein

1

5

High-throughput

0.479

High

123296

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.479

High

123297

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

123307

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

3

High-throughput

0.479

High

123314

RBM4
RNA-binding protein 4

1

3

Small-scale

0.479

High

123316

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

15

Small-scale

0.479

High

123318

NSRP1
Nuclear speckle splicing regulatory protein 1

1

6

High-throughput

0.479

High

123319

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

5

High-throughput

0.479

High

123320

HIPK2
Homeodomain-interacting protein kinase 2

1

4

Small-scale

0.479

High

123328

MDN1
Midasin

1

1

Small-scale

0.479

High

123329

DCA13
DDB1- and CUL4-associated factor 13

1

10

High-throughput

0.479

High

123330

DDX56
Probable ATP-dependent RNA helicase DDX56

1

6

High-throughput

0.479

High

123331

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

1

20

High-throughput

0.479

High

123336

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

123346

SCML2
Sex comb on midleg-like protein 2

1

20

Small-scale

0.479

High

123349

KDM3A
Lysine-specific demethylase 3A

1

15

High-throughput

0.479

High

123352

MORC2
ATPase MORC2

1

1

Small-scale

0.479

High

123177

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.470

High

123195

CBS
Cystathionine beta-synthase

1

0

Small-scale

0.460

High

123141

E41L2
Band 4.1-like protein 2

1

0

High-throughput

0.458

High

123259

FA76B
Protein FAM76B

1

0

High-throughput

0.458

High

123264

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

123270

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

123309

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

123323

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

111555

K7EK07
Histone H3

1

20

High-throughput

0.445

High

123150

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

17

High-throughput

0.445

High

123161

ADT2
ADP/ATP translocase 2

1

5

High-throughput

0.445

High

123172

FER
Tyrosine-protein kinase Fer

1

6

High-throughput

0.445

High

123199

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.445

High

123203

CENPF
Centromere protein F

1

10

High-throughput

0.445

High

123239

H11
Histone H1.1

1

13

High-throughput

0.445

High

123262

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

2

High-throughput

0.445

High

123275

ZN546
Zinc finger protein 546

1

20

High-throughput

0.445

High

123306

SMG1
Serine/threonine-protein kinase SMG1

1

3

High-throughput

0.445

High

123315

RNF17
RING finger protein 17

1

1

High-throughput

0.445

High

123326

MOV10
Helicase MOV-10

1

4

High-throughput

0.445

High

123345

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.445

High

123347

RUVB2
RuvB-like 2

1

1

High-throughput

0.445

High

123286

LNX2
Ligand of Numb protein X 2

1

4

Small-scale

0.439

High

123138

TRNK1
TPR and ankyrin repeat-containing protein 1

1

1

High-throughput

0.437

High

123192

SDC2
Syndecan-2

1

1

High-throughput

0.437

High

123248

SRC8
Src substrate cortactin

1

2

High-throughput

0.437

High

123263

RN213
E3 ubiquitin-protein ligase RNF213

1

2

High-throughput

0.437

High

123284

DI3L2
DIS3-like exonuclease 2

1

1

High-throughput

0.437

High

123292

RIN3
Ras and Rab interactor 3

1

4

High-throughput

0.437

High

123322

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

123333

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

123343

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.437

High

123344

ANR26
Ankyrin repeat domain-containing protein 26

1

4

High-throughput

0.437

High

123293

MDM1
Nuclear protein MDM1

1

0

High-throughput

0.426

High

91485

E7ESK6
Syndecan

1

1

High-throughput

0.407

High

123341

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

3

High-throughput

0.407

High

123185

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.279

Low

123235

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

123266

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

123272

RM55
Large ribosomal subunit protein mL55

1

0

High-throughput

0.279

Low

123304

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

123310

TTC1
Tetratricopeptide repeat protein 1

1

0

High-throughput

0.279

Low

123164

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

123165

GELS
Gelsolin

1

0

High-throughput

0.268

Low

123188

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

123274

RN180
E3 ubiquitin-protein ligase RNF180

1

0

Small-scale

0.249

Low

123313

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.249

Low

123151

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.232

Low

123302

STALP
AMSH-like protease

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024