Protein: RRP8
25S rRNA (adenine(645)-N(1))-methyltransferase (EC 2.1.1.287) (Ribosomal RNA-processing protein 8)

Gene: RRP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P38961

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0016433 - rRNA (adenine) methyltransferase activity
GO:0030686 - 90S preribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

808276

RRP8
25S rRNA

1

0

High-throughput

0.586

High

808302

DHR1
Probable ATP-dependent RNA helicase DHR1

2

2

High-throughput

0.584

High

808315

NOC4
Nucleolar complex protein 4

2

4

High-throughput

0.584

High

677395

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

808282

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

523939

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.489

High

149762

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

433640

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

441906

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

512438

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513009

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

585275

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

632669

DBP4
ATP-dependent RNA helicase HCA4

1

6

High-throughput

0.479

High

673177

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

678392

PWP2
Periodic tryptophan protein 2

1

3

High-throughput

0.479

High

753368

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

793476

MAK5
ATP-dependent RNA helicase MAK5

1

4

High-throughput

0.479

High

808278

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

High-throughput

0.479

High

808283

ROK1
ATP-dependent RNA helicase ROK1

1

1

High-throughput

0.479

High

808289

UTP22
U3 small nucleolar RNA-associated protein 22

1

2

High-throughput

0.479

High

808291

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

808292

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

808298

UTP17
NET1-associated nuclear protein 1

1

4

High-throughput

0.479

High

808301

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

High-throughput

0.479

High

808303

UTP15
U3 small nucleolar RNA-associated protein 15

1

2

High-throughput

0.479

High

808305

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.479

High

808306

FCF1
rRNA-processing protein FCF1

1

1

High-throughput

0.479

High

808309

UTP13
U3 small nucleolar RNA-associated protein 13

1

4

High-throughput

0.479

High

808310

UTP21
U3 small nucleolar RNA-associated protein 21

1

6

High-throughput

0.479

High

808313

ESF1
Pre-rRNA-processing protein ESF1

1

1

High-throughput

0.479

High

808314

RRP9
Ribosomal RNA-processing protein 9

1

1

High-throughput

0.479

High

808318

UTP4
U3 small nucleolar RNA-associated protein 4

1

3

High-throughput

0.479

High

808329

UTP12
U3 small nucleolar RNA-associated protein 12

1

4

High-throughput

0.479

High

808330

NOP56
Nucleolar protein 56

1

4

High-throughput

0.479

High

808331

NOP58
Nucleolar protein 58

1

4

High-throughput

0.479

High

808333

RRP12
Ribosomal RNA-processing protein 12

1

1

High-throughput

0.479

High

808334

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

435091

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435964

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

674623

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689455

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

747359

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

754277

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

758371

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

798216

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

806521

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

808279

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

808280

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

808281

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

808284

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

High-throughput

0.458

High

808286

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

808290

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

808295

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

808296

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

808304

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

808312

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

808316

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

808320

NSE1
Non-structural maintenance of chromosomes element 1

1

0

High-throughput

0.458

High

808321

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

808323

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

808325

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

808326

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

808327

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

808307

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.438

High

504212

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

646400

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

745737

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.437

High

808293

H3
Histone H3

1

1

High-throughput

0.437

High

544861

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

526687

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

741575

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

419733

H2A2
Histone H2A.2

1

0

High-throughput

0.279

Low

721932

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

383701

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410130

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

436412

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.249

Low

455063

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503043

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

514639

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

594365

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

707085

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

734978

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

778328

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

798093

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.249

Low

802173

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

808277

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

808285

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

808287

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

808288

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

808294

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

808297

IMA1
Importin subunit alpha

1

0

High-throughput

0.249

Low

808299

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

808300

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

808308

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.249

Low

808311

IMB1
Importin subunit beta-1

1

0

High-throughput

0.249

Low

808319

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

808322

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

808324

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

808328

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.249

Low

808332

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.249

Low

808317

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025