Protein: LCF4
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Fatty acid activator 4) (Fatty acyl-CoA synthetase) (FACS) (Long-chain acyl-CoA synthetase 4)

Gene: LCF4, FAA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P47912

Gene Ontology (top 5):
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579697

HSC82
ATP-dependent molecular chaperone HSC82

3

6

High-throughput

0.646

High

796234

FAT1
Very long-chain fatty acid transport protein

1

5

Small-scale

0.618

High

808947

LCF3
Long-chain-fatty-acid--CoA ligase 3

1

5

High-throughput

0.618

High

868424

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

6

High-throughput

0.618

High

868460

PGC1
Phosphatidylglycerol phospholipase C

2

0

High-throughput

0.585

High

524464

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.571

High

527094

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.571

High

633487

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.536

High

644637

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.536

High

868454

PSR2
Probable phosphatase PSR2

1

1

High-throughput

0.536

High

868455

RBX1
RING-box protein HRT1

1

2

High-throughput

0.536

High

850084

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.533

High

453677

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.513

High

453967

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

656329

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

0

High-throughput

0.513

High

743348

FIMB
Fimbrin

1

0

High-throughput

0.513

High

757840

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.513

High

868433

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

868441

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.513

High

738670

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.489

High

762983

SPT7
SAGA complex subunit SPT7

1

5

High-throughput

0.489

High

793949

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

4

High-throughput

0.489

High

808524

TEM1
Protein TEM1

1

5

High-throughput

0.489

High

868440

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.489

High

868443

UTP5
U3 small nucleolar RNA-associated protein 5

1

4

High-throughput

0.489

High

518070

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

432343

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

439377

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

392994

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.479

High

430880

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

435207

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

514717

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

558796

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

679845

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

737902

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

747935

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

796097

IMB2
Importin subunit beta-2

1

1

High-throughput

0.479

High

803606

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

815170

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

868442

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

868444

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

868464

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

868465

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

868466

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

868451

LEC1
PX domain-containing protein LEC1

1

0

Small-scale

0.460

High

868452

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.460

High

368461

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

417137

VDAC1
Non-selective voltage-gated ion channel 1

1

0

Small-scale

0.458

High

436048

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

518329

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.458

High

585715

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.458

High

610173

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.458

High

674712

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

735057

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

778417

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

797757

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

802264

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

804855

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.458

High

805352

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.458

High

813293

FHP
Flavohemoprotein

1

0

High-throughput

0.458

High

828298

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

868425

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

868432

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.458

High

868434

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

868437

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

868438

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

868447

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

868453

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

868456

SGO1
Shugoshin

1

0

High-throughput

0.458

High

868457

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

868461

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

868462

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

868463

HSP42
Heat shock protein 42

1

0

High-throughput

0.458

High

394700

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

509627

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

High-throughput

0.445

High

545461

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

741922

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

819188

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

382198

H4
Histone H4

1

1

High-throughput

0.437

High

670894

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

707558

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

779284

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

812457

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

844523

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

868426

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

868431

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

868436

H3
Histone H3

1

3

High-throughput

0.437

High

868459

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

386775

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

554364

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.426

High

592352

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

747459

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.426

High

812244

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

836779

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

868429

YGI2
Uncharacterized protein YGL082W

1

0

High-throughput

0.426

High

868427

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.407

High

826638

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

622378

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

743437

MSS4
Protein DSS4

1

0

High-throughput

0.279

Low

755128

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.279

Low

868430

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.279

Low

868439

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.279

Low

868446

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.279

Low

405111

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

798100

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.251

Low

820313

PEX17
Peroxisomal membrane protein PEX17

1

0

High-throughput

0.251

Low

410219

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

441999

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

503130

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504300

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

513099

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

647160

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

676654

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

806761

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

827549

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

868435

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

868445

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

868448

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

868449

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

868450

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

868458

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

807241

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

868428

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.232

Low

868467

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025