Protein: MLX
Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4)

Gene: MLX
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9UH92

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437594

MLXIP
MLX-interacting protein

5

16

Small-scale

0.933

High

1445927

MLXPL
Carbohydrate-responsive element-binding protein

4

17

Small-scale

0.910

High

1405472

MNT
Max-binding protein MNT

3

19

Small-scale

0.880

High

1459690

MLX
Max-like protein X

2

15

Small-scale

0.826

High

1310140

MGAP
MAX gene-associated protein

2

4

High-throughput

0.811

High

893750

MEOX1
Homeobox protein MOX-1

2

12

High-throughput

0.783

High

1050756

MAD1
Max dimerization protein 1

2

19

Small-scale

0.768

High

1128584

MAD4
Max dimerization protein 4

2

19

Small-scale

0.754

High

952375

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

5

2

High-throughput

0.722

High

1061913

TLE5
TLE family member 5

4

1

High-throughput

0.698

High

1232625

Q6FHY5
MEOX2 protein

1

13

High-throughput

0.665

High

1037120

ID3
DNA-binding protein inhibitor ID-3

1

3

Small-scale

0.656

High

166580

BACH1
Transcription regulator protein BACH1

2

16

High-throughput

0.628

High

625689

CSK22
Casein kinase II subunit alpha'

2

10

High-throughput

0.628

High

998094

CSK21
Casein kinase II subunit alpha

2

9

High-throughput

0.628

High

1111989

SNX1
Sorting nexin-1

2

3

High-throughput

0.628

High

1459695

SNX5
Sorting nexin-5

2

3

High-throughput

0.628

High

894229

MEOX2
Homeobox protein MOX-2

1

12

High-throughput

0.621

High

168766

CSKP
Peripheral plasma membrane protein CASK

2

10

High-throughput

0.606

High

297877

PIAS2
E3 SUMO-protein ligase PIAS2

2

9

High-throughput

0.606

High

1238201

RHBD2
Rhomboid domain-containing protein 2

2

1

High-throughput

0.606

High

1253093

ZN620
Zinc finger protein 620

2

1

High-throughput

0.606

High

1348562

LNX1
E3 ubiquitin-protein ligase LNX

2

5

High-throughput

0.606

High

1419360

BACH2
Transcription regulator protein BACH2

2

17

High-throughput

0.606

High

1430357

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

2

High-throughput

0.606

High

1030341

AMPD2
AMP deaminase 2

2

0

High-throughput

0.602

High

852127

TNNT2
Troponin T, cardiac muscle

2

0

High-throughput

0.580

High

1187761

KR133
Keratin-associated protein 13-3

2

0

High-throughput

0.580

High

1330697

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.580

High

1386904

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1398733

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

1127225

RBM39
RNA-binding protein 39

1

20

High-throughput

0.573

High

1459697

MTCH2
Mitochondrial carrier homolog 2

2

12

High-throughput

0.571

High

821611

TCPZ
T-complex protein 1 subunit zeta

1

9

High-throughput

0.541

High

730329

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

966986

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

972101

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.536

High

990839

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

995333

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.536

High

1459696

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

1

High-throughput

0.536

High

1325772

LNX2
Ligand of Numb protein X 2

1

6

High-throughput

0.512

High

1459691

S30BP
SAP30-binding protein

1

2

Small-scale

0.508

High

423399

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

993795

UBC9
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.481

High

1459693

ZBT32
Zinc finger and BTB domain-containing protein 32

1

8

High-throughput

0.481

High

980492

H4
Histone H4

1

18

High-throughput

0.479

High

1033290

EWS
RNA-binding protein EWS

1

16

High-throughput

0.479

High

1125722

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

5

High-throughput

0.479

High

1366615

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1459692

FBXL7
F-box/LRR-repeat protein 7

1

3

Small-scale

0.479

High

2917

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.470

High

1270734

Q7KZS0
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.470

High

1293690

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1459694

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1312298

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.437

High

1414495

DERL1
Derlin-1

1

1

High-throughput

0.437

High

1451743

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.437

High

1453384

MTCH1
Mitochondrial carrier homolog 1

1

11

High-throughput

0.437

High

328831

CSPG5
Chondroitin sulfate proteoglycan 5

2

0

High-throughput

0.328

High

71532

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025