Protein: CRY2
Cryptochrome-2

Gene: CRY2
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q49AN0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0003677 - DNA binding
GO:0003684 - damaged DNA binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165988

PER2
Period circadian protein homolog 2

5

20

Small-scale

0.922

High

1082120

CRY1
Cryptochrome-1

4

7

Small-scale

0.892

High

182350

PER1
Period circadian protein homolog 1

3

20

High-throughput

0.849

High

1115719

CRY2
Cryptochrome-2

2

7

Small-scale

0.767

High

1115767

FBXL3
F-box/LRR-repeat protein 3

7

7

Small-scale

0.751

High

830380

KC1E
Casein kinase I isoform epsilon

4

8

Small-scale

0.702

High

881735

PER3
Period circadian protein homolog 3

1

20

High-throughput

0.691

High

1115720

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

1

High-throughput

0.675

High

822280

KC1D
Casein kinase I isoform delta

3

8

High-throughput

0.675

High

1070066

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.667

High

1115737

TEKT4
Tektin-4

3

1

High-throughput

0.667

High

1115745

AP2M1
AP-2 complex subunit mu

3

1

High-throughput

0.667

High

283311

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3

0

High-throughput

0.646

High

928934

SKP1
S-phase kinase-associated protein 1

2

1

Small-scale

0.628

High

1032443

CTBP1
C-terminal-binding protein 1

2

1

High-throughput

0.628

High

1115755

XRN2
5'-3' exoribonuclease 2

3

0

High-throughput

0.625

High

858631

PPP5
Serine/threonine-protein phosphatase 5

2

7

Small-scale

0.614

High

642062

KRA59
Keratin-associated protein 5-9

2

8

High-throughput

0.606

High

889259

KR107
Keratin-associated protein 10-7

2

7

High-throughput

0.606

High

889497

KR108
Keratin-associated protein 10-8

2

7

High-throughput

0.606

High

991572

KRA11
Keratin-associated protein 1-1

2

7

High-throughput

0.606

High

1020700

TRAF2
TNF receptor-associated factor 2

2

2

High-throughput

0.606

High

1023680

TRAF1
TNF receptor-associated factor 1

2

2

High-throughput

0.606

High

1115726

KRA57
Keratin-associated protein 5-7

2

8

High-throughput

0.606

High

1115727

KRA54
Keratin-associated protein 5-4

2

6

High-throughput

0.606

High

1115729

KRA51
Keratin-associated protein 5-1

2

1

High-throughput

0.606

High

1115735

KRA13
Keratin-associated protein 1-3

2

6

High-throughput

0.606

High

1115752

KRA98
Keratin-associated protein 9-8

2

6

High-throughput

0.606

High

1115753

KRA42
Keratin-associated protein 4-2

2

6

High-throughput

0.606

High

1115759

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1115757

TXNIP
Thioredoxin-interacting protein

2

0

High-throughput

0.602

High

126133

BMAL1
Basic helix-loop-helix ARNT-like protein 1

2

18

Small-scale

0.586

High

181527

CLOCK
Circadian locomoter output cycles protein kaput

2

15

Small-scale

0.586

High

1115766

FXL21
Putative F-box/LRR-repeat protein 21

2

7

Small-scale

0.586

High

162811

XPO1
Exportin-1

2

4

High-throughput

0.584

High

1082211

DDB1
DNA damage-binding protein 1

2

2

Small-scale

0.584

High

1115744

FBXW7
F-box/WD repeat-containing protein 7

2

3

Small-scale

0.584

High

70980

ZBT42
Zinc finger and BTB domain-containing protein 42

2

0

High-throughput

0.580

High

175687

TRI18
E3 ubiquitin-protein ligase Midline-1

2

0

High-throughput

0.580

High

316253

NADK
NAD kinase

2

0

High-throughput

0.580

High

1109380

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.580

High

1115724

K1C40
Keratin, type I cytoskeletal 40

2

0

High-throughput

0.580

High

1115730

KRA52
Keratin-associated protein 5-2

2

0

High-throughput

0.580

High

1115756

SDCB2
Syntenin-2

2

0

High-throughput

0.580

High

931666

CSK2B
Casein kinase II subunit beta

1

3

Small-scale

0.561

High

471692

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

1

High-throughput

0.553

High

1102864

VWC2
Brorin

2

1

High-throughput

0.553

High

1079082

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.541

High

617568

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.536

High

1041021

CUL1
Cullin-1

1

2

Small-scale

0.536

High

868527

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

1115768

TIM
Protein timeless homolog

1

2

Small-scale

0.515

High

484615

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.515

High

660529

GRN
Progranulin

1

1

High-throughput

0.515

High

966561

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

1115761

SRTD4
SERTA domain-containing protein 4

1

0

High-throughput

0.513

High

1109289

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

527

NBPFJ
Neuroblastoma breakpoint family member 19

1

1

High-throughput

0.481

High

360001

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.481

High

672430

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

4

High-throughput

0.481

High

1058672

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

High-throughput

0.481

High

1080003

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.481

High

1082506

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

3

High-throughput

0.481

High

1115728

KRA53
Keratin-associated protein 5-3

1

8

High-throughput

0.481

High

1115732

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.481

High

1115747

TTC1
Tetratricopeptide repeat protein 1

1

7

Small-scale

0.481

High

1115749

NPAS2
Neuronal PAS domain-containing protein 2

1

16

High-throughput

0.481

High

1115754

BHE41
Class E basic helix-loop-helix protein 41

1

10

High-throughput

0.481

High

121779

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.479

High

134067

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

High-throughput

0.479

High

162064

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

5

High-throughput

0.479

High

181705

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

6

High-throughput

0.479

High

195456

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.479

High

197317

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.479

High

198643

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

270647

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.479

High

272163

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

5

High-throughput

0.479

High

304192

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

High-throughput

0.479

High

311557

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.479

High

430970

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

431919

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

438230

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

499794

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

504179

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

514015

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.479

High

523799

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

531170

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

541371

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

550805

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

572975

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.479

High

582321

NUCL
Nucleolin

1

4

High-throughput

0.479

High

598149

FLNA
Filamin-A

1

1

High-throughput

0.479

High

606431

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

616348

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

646945

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

649538

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

653988

MAP4
Microtubule-associated protein 4

1

1

High-throughput

0.479

High

677984

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.479

High

708458

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.479

High

708668

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.479

High

708937

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.479

High

730273

PRS7
26S proteasome regulatory subunit 7

1

5

High-throughput

0.479

High

770864

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

782917

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.479

High

783049

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

789819

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

793986

MATR3
Matrin-3

1

3

High-throughput

0.479

High

798680

PRS6B
26S proteasome regulatory subunit 6B

1

5

High-throughput

0.479

High

821238

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.479

High

825966

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

827406

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

834760

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.479

High

842893

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

843224

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.479

High

850079

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

6

High-throughput

0.479

High

852946

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.479

High

853613

IMA5
Importin subunit alpha-5

1

4

High-throughput

0.479

High

862405

ACLY
ATP-citrate synthase

1

1

High-throughput

0.479

High

874522

XPO2
Exportin-2

1

1

High-throughput

0.479

High

877292

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

880124

SYMC
Methionine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

892821

IF4A1
Eukaryotic initiation factor 4A-I

1

6

High-throughput

0.479

High

903969

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

907048

PRS8
26S proteasome regulatory subunit 8

1

6

High-throughput

0.479

High

909626

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

910448

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

915206

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.479

High

919101

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

927823

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.479

High

932733

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

934210

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.479

High

943257

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.479

High

944272

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

984360

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.479

High

991783

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

High-throughput

0.479

High

1027672

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

1051872

IF4A2
Eukaryotic initiation factor 4A-II

1

9

High-throughput

0.479

High

1064368

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1069693

NONO
Non-POU domain-containing octamer-binding protein

1

4

High-throughput

0.479

High

1071890

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

1115723

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.479

High

1115731

DET1
DET1 homolog

1

1

Small-scale

0.479

High

1115733

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1115734

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.479

High

1115739

GCN1
Stalled ribosome sensor GCN1

1

5

High-throughput

0.479

High

1115740

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

High-throughput

0.479

High

1115741

FUBP2
Far upstream element-binding protein 2

1

4

High-throughput

0.479

High

1115742

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.479

High

1115743

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.479

High

1115746

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

1115748

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.479

High

1115750

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1115760

SMC4
Structural maintenance of chromosomes protein 4

1

1

High-throughput

0.479

High

1115763

DDX20
Probable ATP-dependent RNA helicase DDX20

1

7

High-throughput

0.479

High

1115765

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

1115769

DICER
Endoribonuclease Dicer

1

4

High-throughput

0.479

High

1115770

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1115771

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.479

High

749560

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.460

High

158802

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

164912

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

215639

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

323800

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

390265

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

444176

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.458

High

451907

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.458

High

585965

SPEE
Spermidine synthase

1

0

High-throughput

0.458

High

785944

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

802848

CRKL
Crk-like protein

1

0

High-throughput

0.458

High

863451

COPA
Coatomer subunit alpha

1

0

High-throughput

0.458

High

874995

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

916621

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1051559

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1115725

NXN
Nucleoredoxin

1

0

High-throughput

0.458

High

1115736

GEMI5
Gem-associated protein 5

1

0

High-throughput

0.458

High

1115758

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.458

High

1115764

APC7
Anaphase-promoting complex subunit 7

1

0

High-throughput

0.458

High

1115762

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

393229

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

530898

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.437

High

990471

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.437

High

67109

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1115738

KLHL6
Kelch-like protein 6

2

0

High-throughput

0.316

High

723251

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

High-throughput

0.282

High

1115721

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

1115722

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1115751

DDA1
DET1- and DDB1-associated protein 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024