Protein: UBE3D
E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein)

Gene: UBE3D
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q7Z6J8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006513 - protein monoubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1280108

KTU
Protein kintoun

6

0

High-throughput

0.702

High

276702

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

0

High-throughput

0.638

High

1280114

MEMO1
Protein MEMO1

3

0

High-throughput

0.638

High

731423

STIP1
Stress-induced-phosphoprotein 1

2

0

High-throughput

0.602

High

776980

PPM1A
Protein phosphatase 1A

2

0

High-throughput

0.602

High

997007

TBA4A
Tubulin alpha-4A chain

2

0

High-throughput

0.602

High

1244402

BORA
Protein aurora borealis

2

0

High-throughput

0.602

High

1280112

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.602

High

1280113

KLDC2
Kelch domain-containing protein 2

2

0

High-throughput

0.602

High

848889

MAGAB
Melanoma-associated antigen 11

2

0

High-throughput

0.580

High

551127

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

1100064

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.537

High

682053

RBTN1
Rhombotin-1

1

1

High-throughput

0.536

High

1280099

LMO3
LIM domain only protein 3

1

1

High-throughput

0.536

High

1201984

H90B4
Putative heat shock protein HSP 90-beta 4

2

0

High-throughput

0.528

High

573850

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.513

High

1280103

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.513

High

144182

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

0

Small-scale

0.480

High

1280098

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

Small-scale

0.480

High

750439

CSTF2
Cleavage stimulation factor subunit 2

1

0

High-throughput

0.458

High

867248

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1113543

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1280101

SYMPK
Symplekin

1

0

High-throughput

0.458

High

1280109

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

1280110

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1280111

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

4

0

High-throughput

0.367

High

948001

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.328

High

1280105

CCM2
Cerebral cavernous malformations 2 protein

2

0

High-throughput

0.328

High

1280106

GTPB2
GTP-binding protein 2

2

0

High-throughput

0.328

High

73826

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.279

Low

190411

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

946312

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

1280100

LCN9
Epididymal-specific lipocalin-9

1

0

High-throughput

0.279

Low

1280102

TECT2
Tectonic-2

1

0

High-throughput

0.279

Low

340760

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

0

High-throughput

0.249

Low

1280104

Q9BPW0
Serine/threonine-protein phosphatase

1

0

High-throughput

0.249

Low

1280107

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025