Protein: CCM2
Cerebral cavernous malformations 2 protein (Malcavernin)

Gene: CCM2
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q9BSQ5

Gene Ontology (top 5):
GO:0001570 - vasculogenesis
GO:0001701 - in utero embryonic development
GO:0001885 - endothelial cell development
GO:0003158 - endothelium development
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1407231

M3K3
Mitogen-activated protein kinase kinase kinase 3

3

0

Small-scale

0.825

High

139138

KRIT1
Krev interaction trapped protein 1

11

1

Small-scale

0.761

High

161574

ITBP1
Integrin beta-1-binding protein 1

4

0

Small-scale

0.661

High

1116692

RIN1
Ras and Rab interactor 1

3

0

High-throughput

0.636

High

1412844

PDC10
Programmed cell death protein 10

3

0

Small-scale

0.632

High

1412853

STK26
Serine/threonine-protein kinase 26

2

1

High-throughput

0.628

High

1412848

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

1

Small-scale

0.624

High

1412842

CCM2
Cerebral cavernous malformations 2 protein

1

0

Small-scale

0.614

High

1353330

DOK4
Docking protein 4

2

0

High-throughput

0.607

High

1358159

TWST2
Twist-related protein 2

2

0

High-throughput

0.607

High

1398667

VTM2L
V-set and transmembrane domain-containing protein 2-like protein

2

0

High-throughput

0.607

High

1412854

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.602

High

1006666

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.527

High

1333810

RDH13
Retinol dehydrogenase 13

1

0

High-throughput

0.513

High

1390258

NRBF2
Nuclear receptor-binding factor 2

1

0

High-throughput

0.513

High

1402512

NEB2
Neurabin-2

1

0

High-throughput

0.513

High

138867

STK25
Serine/threonine-protein kinase 25

1

1

Small-scale

0.479

High

978258

RHOB
Rho-related GTP-binding protein RhoB

1

3

High-throughput

0.479

High

988660

RAC1
Ras-related C3 botulinum toxin substrate 1

1

1

High-throughput

0.479

High

1412846

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

1

Small-scale

0.479

High

468749

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.458

High

540647

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

1255298

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

126772

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.437

High

962428

RHOA
Transforming protein RhoA

1

3

Small-scale

0.437

High

1412847

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.437

High

457657

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

714648

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

0

High-throughput

0.426

High

1061286

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.426

High

1219175

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.426

High

1242443

WDR73
Integrator complex assembly factor WDR73

1

0

High-throughput

0.426

High

1412843

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.426

High

1412852

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.426

High

1412856

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.426

High

1412845

TLRN1
Talin rod domain-containing protein 1

4

0

High-throughput

0.359

High

238599

RAD21
Double-strand-break repair protein rad21 homolog

2

0

High-throughput

0.328

High

940569

AP1S2
AP-1 complex subunit sigma-2

2

0

High-throughput

0.328

High

1280105

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.328

High

725107

HXC8
Homeobox protein Hox-C8

2

0

High-throughput

0.316

High

1412855

KLDC2
Kelch domain-containing protein 2

2

0

High-throughput

0.313

High

1412850

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

165723

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

0

High-throughput

0.279

Low

582114

PGAM2
Phosphoglycerate mutase 2

1

0

High-throughput

0.279

Low

1218857

GP107
Protein GPR107

1

0

High-throughput

0.279

Low

1400384

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1410205

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

956463

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.249

Low

1346907

SNIP1
Smad nuclear-interacting protein 1

1

0

Small-scale

0.249

Low

317475

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.232

Low

1208273

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low

1294987

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

High-throughput

0.232

Low

1386161

FWCH2
FLYWCH family member 2

1

0

High-throughput

0.232

Low

1412849

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.232

Low

1412851

ING3
Inhibitor of growth protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025