Protein: CPSF4
Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)

Gene: CPSF4
Organism: Homo sapiens
Interactions: 88
UniProt ID: O95639

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0006397 - mRNA processing
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

340756

FIP1
Pre-mRNA 3'-end-processing factor FIP1

8

6

Small-scale

0.974

High

340774

WDR33
pre-mRNA 3' end processing protein WDR33

5

4

Small-scale

0.919

High

340745

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

4

4

High-throughput

0.895

High

340729

CSTF2
Cleavage stimulation factor subunit 2

2

11

High-throughput

0.789

High

340775

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

15

Small-scale

0.737

High

340792

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

4

9

High-throughput

0.704

High

340767

SYMPK
Symplekin

4

2

High-throughput

0.699

High

340741

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

340744

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

340751

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.691

High

340752

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.691

High

340761

ZCH18
Zinc finger CCCH domain-containing protein 18

3

10

High-throughput

0.667

High

340787

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

3

9

High-throughput

0.667

High

191275

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

3

1

High-throughput

0.662

High

340772

EAF1
ELL-associated factor 1

3

0

High-throughput

0.638

High

340754

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

1

High-throughput

0.628

High

340784

SMYD2
N-lysine methyltransferase SMYD2

2

2

High-throughput

0.628

High

340722

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.618

High

340769

CELF1
CUGBP Elav-like family member 1

1

20

High-throughput

0.618

High

340795

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.618

High

340791

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

3

High-throughput

0.606

High

340725

MYOG
Myogenin

2

0

High-throughput

0.580

High

340749

RNPS1
RNA-binding protein with serine-rich domain 1

1

19

High-throughput

0.575

High

340779

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

3

Small-scale

0.575

High

340783

LN28A
Protein lin-28 homolog A

1

15

High-throughput

0.575

High

340740

HTRA4
Serine protease HTRA4

2

1

High-throughput

0.574

High

340773

LZTS2
Leucine zipper putative tumor suppressor 2

2

5

High-throughput

0.574

High

340735

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.573

High

340718

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

340766

CBP
CREB-binding protein

1

5

Small-scale

0.561

High

340753

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.553

High

180197

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.536

High

229921

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.536

High

244210

NUAK1
NUAK family SNF1-like kinase 1

1

1

High-throughput

0.536

High

340721

NPM
Nucleophosmin

1

1

Small-scale

0.536

High

340724

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.536

High

340733

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.536

High

340734

CLK2
Dual specificity protein kinase CLK2

1

6

High-throughput

0.536

High

340788

WRP73
WD repeat-containing protein WRAP73

1

2

Small-scale

0.514

High

340747

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

340755

CDC73
Parafibromin

1

0

Small-scale

0.513

High

340768

KLK6
Kallikrein-6

1

0

High-throughput

0.513

High

340770

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

340782

CSN7B
COP9 signalosome complex subunit 7b

1

0

High-throughput

0.513

High

340737

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.489

High

340746

MALL
MAL-like protein

1

1

High-throughput

0.489

High

340764

ANR49
Ankyrin repeat domain-containing protein 49

1

4

High-throughput

0.489

High

340771

SAHH3
Adenosylhomocysteinase 3

1

3

High-throughput

0.489

High

340780

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.489

High

340796

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.489

High

172371

XPO1
Exportin-1

1

7

High-throughput

0.479

High

217669

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

340717

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

340720

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

340723

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

340726

GATA1
Erythroid transcription factor

1

1

High-throughput

0.479

High

340727

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

340730

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

340732

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

340736

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

340739

H4
Histone H4

1

4

High-throughput

0.479

High

340742

VIGLN
Vigilin

1

10

High-throughput

0.479

High

340743

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

340748

MDC1
Mediator of DNA damage checkpoint protein 1

1

7

High-throughput

0.479

High

340750

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

340758

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

340759

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

4

Small-scale

0.479

High

340762

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

340763

SP7
Transcription factor Sp7

1

1

High-throughput

0.479

High

340765

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

340776

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

340781

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

340785

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

340786

NOP53
Ribosome biogenesis protein NOP53

1

5

High-throughput

0.479

High

340789

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

340790

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

340797

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

340719

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

340738

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.437

High

340778

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

340793

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

340757

NBEL2
Neurobeachin-like protein 2

1

4

High-throughput

0.407

High

340794

RHG26
Rho GTPase-activating protein 26

2

0

High-throughput

0.298

High

340716

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.279

Low

340731

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

340777

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

340760

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

High-throughput

0.249

Low

340728

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025