Protein: DCTN5
Dynactin subunit 5 (Dynactin subunit p25)

Gene: DCTN5
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9BTE1

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0003281 - ventricular septum development
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1413457

DCTN4
Dynactin subunit 4

2

2

High-throughput

0.776

High

1110710

DCTN2
Dynactin subunit 2

6

2

High-throughput

0.735

High

866804

CAZA2
F-actin-capping protein subunit alpha-2

5

3

High-throughput

0.716

High

837250

ACTY
Beta-centractin

4

6

High-throughput

0.691

High

1123797

DCTN1
Dynactin subunit 1

4

3

High-throughput

0.691

High

133377

DCTN6
Dynactin subunit 6

3

2

High-throughput

0.662

High

867388

CAPZB
F-actin-capping protein subunit beta

3

1

High-throughput

0.650

High

1186186

INAVA
Innate immunity activator protein

2

3

High-throughput

0.628

High

1413451

MS18A
Protein Mis18-alpha

2

1

High-throughput

0.628

High

1413458

NINL
Ninein-like protein

2

1

High-throughput

0.614

High

329099

KLHL2
Kelch-like protein 2

2

1

High-throughput

0.611

High

1169032

CSPP1
Centrosome and spindle pole-associated protein 1

2

1

High-throughput

0.611

High

1413445

PDGFD
Platelet-derived growth factor D

3

1

High-throughput

0.604

High

298221

DCTN3
Dynactin subunit 3

2

1

High-throughput

0.601

High

958502

ACTZ
Alpha-centractin

2

6

High-throughput

0.601

High

1413452

ARP10
Actin-related protein 10

2

4

High-throughput

0.601

High

991691

DYL1
Dynein light chain 1, cytoplasmic

2

0

High-throughput

0.580

High

462803

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

1

High-throughput

0.574

High

1392982

CC120
Coiled-coil domain-containing protein 120

2

3

High-throughput

0.574

High

1413446

DB127
Beta-defensin 127

2

1

High-throughput

0.574

High

396840

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1413454

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

1372059

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.549

High

442460

GELS
Gelsolin

1

2

High-throughput

0.536

High

915175

CAZA1
F-actin-capping protein subunit alpha-1

1

3

High-throughput

0.536

High

953065

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

993315

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.536

High

1007238

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.536

High

1146467

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.536

High

1149705

MED22
Mediator of RNA polymerase II transcription subunit 22

1

1

High-throughput

0.536

High

1152232

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

1363685

TCPW
T-complex protein 1 subunit zeta-2

1

1

High-throughput

0.536

High

540648

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.513

High

610861

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.513

High

721061

CLIP1
CAP-Gly domain-containing linker protein 1

1

0

High-throughput

0.513

High

1124032

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

1413459

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

343158

CXL14
C-X-C motif chemokine 14

1

1

High-throughput

0.489

High

1215576

N42L1
NEDD4-binding protein 2-like 1

1

1

High-throughput

0.489

High

1256421

SEP14
Septin-14

1

1

High-throughput

0.489

High

1413447

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.489

High

1413449

RIC8A
Chaperone Ric-8A

1

1

High-throughput

0.489

High

1413456

IL17B
Interleukin-17B

1

1

High-throughput

0.489

High

1381451

PMEPA
Protein TMEPAI

1

1

Small-scale

0.481

High

242762

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

1367150

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

158308

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

1100314

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1413455

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

530306

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1413448

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1196908

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.426

High

94327

D6R9G5
Kelch like family member 2

1

3

High-throughput

0.407

High

1413450

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.407

High

1379874

FATE1
Fetal and adult testis-expressed transcript protein

1

0

High-throughput

0.299

High

1160739

DREB
Drebrin

1

0

High-throughput

0.279

Low

1191956

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.279

Low

1413453

CRNN
Cornulin

1

0

High-throughput

0.279

Low

1271826

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

255193

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

1390782

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025