Protein: DCTN6
Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3)

Gene: DCTN6
Organism: Homo sapiens
Interactions: 69
UniProt ID: O00399

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005869 - dynactin complex
GO:0007052 - mitotic spindle organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

133342

CAZA2
F-actin-capping protein subunit alpha-2

5

1

High-throughput

0.716

High

133353

DCTN2
Dynactin subunit 2

5

1

High-throughput

0.716

High

133354

DCTN1
Dynactin subunit 1

5

1

High-throughput

0.716

High

133341

ACTY
Beta-centractin

4

2

High-throughput

0.691

High

133348

ACTZ
Alpha-centractin

3

2

High-throughput

0.662

High

133377

DCTN5
Dynactin subunit 5

3

2

High-throughput

0.662

High

133384

ARP10
Actin-related protein 10

3

1

High-throughput

0.662

High

133387

DCTN4
Dynactin subunit 4

3

1

High-throughput

0.662

High

133351

GPS2
G protein pathway suppressor 2

3

0

High-throughput

0.638

High

133370

SMIP6
Sperm microtubule inner protein 6

3

0

High-throughput

0.638

High

133390

ORC6
Origin recognition complex subunit 6

3

0

High-throughput

0.638

High

133329

DCTN3
Dynactin subunit 3

3

0

High-throughput

0.634

High

133343

CAPZB
F-actin-capping protein subunit beta

3

0

High-throughput

0.634

High

133383

MS18A
Protein Mis18-alpha

3

0

High-throughput

0.634

High

133368

AROS
Active regulator of SIRT1

2

0

High-throughput

0.602

High

133330

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

133360

CSPP1
Centrosome and spindle pole-associated protein 1

2

0

High-throughput

0.585

High

133326

ZBT43
Zinc finger and BTB domain-containing protein 43

2

1

High-throughput

0.574

High

133328

AVIL
Advillin

2

1

High-throughput

0.574

High

133361

INAVA
Innate immunity activator protein

2

1

High-throughput

0.574

High

133374

CC120
Coiled-coil domain-containing protein 120

2

1

High-throughput

0.574

High

133350

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.559

High

133333

GELS
Gelsolin

1

1

High-throughput

0.536

High

133344

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.536

High

133336

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.518

High

133372

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

133327

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

133340

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

133355

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.513

High

133357

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

133371

CC4L
C-C motif chemokine 4-like

1

1

High-throughput

0.489

High

133376

CCL19
C-C motif chemokine 19

1

1

High-throughput

0.489

High

133358

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.486

High

133325

DCTN6
Dynactin subunit 6

1

0

Small-scale

0.480

High

133332

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

133334

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

133386

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

133391

NCOA3
Nuclear receptor coactivator 3

1

0

Small-scale

0.460

High

133337

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

133347

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

133352

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.458

High

133389

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

133345

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.445

High

133338

RAC2
Ras-related C3 botulinum toxin substrate 2

1

0

High-throughput

0.426

High

94294

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

133339

C4BPB
C4b-binding protein beta chain

3

0

High-throughput

0.347

High

133378

PDGFD
Platelet-derived growth factor D

3

0

High-throughput

0.345

High

133335

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.328

High

133375

MERB1
bMERB domain-containing protein 1

2

0

High-throughput

0.328

High

133379

DB127
Beta-defensin 127

2

0

High-throughput

0.328

High

133388

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

0

High-throughput

0.328

High

133367

Q86V94
LOC554223 protein

2

0

High-throughput

0.318

High

133331

CXL14
C-X-C motif chemokine 14

1

0

High-throughput

0.279

Low

133349

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

133356

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.279

Low

133362

N42L1
NEDD4-binding protein 2-like 1

1

0

High-throughput

0.279

Low

133363

C102B
Coiled-coil domain-containing protein 102B

1

0

High-throughput

0.279

Low

133364

KLC3
Kinesin light chain 3

1

0

High-throughput

0.279

Low

133366

SEP14
Septin-14

1

0

High-throughput

0.279

Low

133369

ABRA
Actin-binding Rho-activating protein

1

0

High-throughput

0.279

Low

133380

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

133381

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.279

Low

133385

IL17B
Interleukin-17B

1

0

High-throughput

0.279

Low

133373

PMEPA
Protein TMEPAI

1

0

Small-scale

0.275

Low

133346

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

133365

LMTK1
Serine/threonine-protein kinase LMTK1

1

0

High-throughput

0.249

Low

133359

ZNF74
Zinc finger protein 74

1

0

High-throughput

0.232

Low

133382

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025