Protein: DCTN4
Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)

Gene: DCTN4
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q9UJW0

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0001725 - stress fiber
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

958538

ACTZ
Alpha-centractin

5

5

Small-scale

0.915

High

837267

ACTY
Beta-centractin

4

5

High-throughput

0.895

High

1452952

ARP10
Actin-related protein 10

3

4

High-throughput

0.843

High

953171

ACTB
Actin, cytoplasmic 1

2

2

High-throughput

0.789

High

993375

ACTG
Actin, cytoplasmic 2

2

2

High-throughput

0.789

High

1413457

DCTN5
Dynactin subunit 5

2

2

High-throughput

0.776

High

1110758

DCTN2
Dynactin subunit 2

6

1

High-throughput

0.736

High

1123864

DCTN1
Dynactin subunit 1

6

2

High-throughput

0.733

High

866860

CAZA2
F-actin-capping protein subunit alpha-2

5

1

High-throughput

0.716

High

867500

CAPZB
F-actin-capping protein subunit beta

4

1

High-throughput

0.683

High

995883

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.665

High

133387

DCTN6
Dynactin subunit 6

3

1

High-throughput

0.662

High

1104279

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

3

2

High-throughput

0.656

High

1063686

GOGA2
Golgin subfamily A member 2

3

0

High-throughput

0.652

High

1206021

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.640

High

915215

CAZA1
F-actin-capping protein subunit alpha-1

2

1

High-throughput

0.611

High

1452755

MS18A
Protein Mis18-alpha

2

0

High-throughput

0.602

High

1460701

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

0

High-throughput

0.602

High

1460700

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.586

High

329118

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

1098608

GPS2
G protein pathway suppressor 2

2

0

High-throughput

0.585

High

1124083

DYHC1
Cytoplasmic dynein 1 heavy chain 1

2

0

High-throughput

0.585

High

1152291

MARE1
Microtubule-associated protein RP/EB family member 1

2

0

High-throughput

0.585

High

1169045

CSPP1
Centrosome and spindle pole-associated protein 1

2

0

High-throughput

0.585

High

1095842

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.573

High

631547

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

243241

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1336497

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.549

High

991759

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

564532

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.528

High

217294

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

442519

GELS
Gelsolin

1

0

High-throughput

0.513

High

721083

CLIP1
CAP-Gly domain-containing linker protein 1

1

0

High-throughput

0.513

High

997557

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.513

High

1085938

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

1149720

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.513

High

1278228

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.513

High

1292982

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

1322396

ABRA
Actin-binding Rho-activating protein

1

0

High-throughput

0.513

High

1371026

TNPO1
Transportin-1

1

0

High-throughput

0.513

High

1446619

RIC8A
Chaperone Ric-8A

1

0

High-throughput

0.513

High

1460703

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

844073

HD
Huntingtin

1

0

High-throughput

0.493

High

1445909

HM20A
High mobility group protein 20A

1

1

High-throughput

0.481

High

156677

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

2

High-throughput

0.479

High

425862

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.479

High

425975

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.479

High

674371

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.479

High

901661

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

1094280

ACACA
Acetyl-CoA carboxylase 1

1

2

High-throughput

0.479

High

1158200

MK14
Mitogen-activated protein kinase 14

1

1

High-throughput

0.479

High

1201968

BRDT
Bromodomain testis-specific protein

1

1

High-throughput

0.479

High

1219368

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.479

High

1256016

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1326375

NIN
Ninein

1

1

High-throughput

0.479

High

1401781

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

1460702

NINL
Ninein-like protein

1

1

High-throughput

0.479

High

129530

MEN1
Menin

1

0

High-throughput

0.458

High

294503

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

298245

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.458

High

352587

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

373443

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

613220

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

630083

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

696811

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

722762

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.458

High

723137

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

761060

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

799560

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

845358

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

0

High-throughput

0.458

High

860048

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.458

High

897557

BPL1
Biotin--protein ligase

1

0

High-throughput

0.458

High

937960

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

976646

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

1030709

ANK2
Ankyrin-2

1

0

Small-scale

0.458

High

1052123

CALD1
Caldesmon

1

0

High-throughput

0.458

High

1100509

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1121365

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1275744

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.458

High

1307949

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

1364666

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1365262

HS105
Heat shock protein 105 kDa

1

0

High-throughput

0.458

High

1367538

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1368192

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1380685

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1391208

BICD1
Protein bicaudal D homolog 1

1

0

High-throughput

0.458

High

1397538

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1405904

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1434182

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1435424

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1453958

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.458

High

1459240

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1460433

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1251976

LMTK1
Serine/threonine-protein kinase LMTK1

1

1

High-throughput

0.437

High

1450968

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

935263

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1159278

ZNF74
Zinc finger protein 74

1

0

High-throughput

0.426

High

1209773

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

94340

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

635435

C4BPB
C4b-binding protein beta chain

3

0

High-throughput

0.347

High

1397950

MERB1
bMERB domain-containing protein 1

2

0

High-throughput

0.328

High

1428289

PDGFD
Platelet-derived growth factor D

2

0

High-throughput

0.328

High

1431170

DB127
Beta-defensin 127

2

0

High-throughput

0.328

High

775782

ATP7B
Copper-transporting ATPase 2

1

0

Small-scale

0.288

High

462819

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

1215579

N42L1
NEDD4-binding protein 2-like 1

1

0

High-throughput

0.279

Low

1340720

CC4L
C-C motif chemokine 4-like

1

0

High-throughput

0.279

Low

106822

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

377774

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

412777

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1192139

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.249

Low

219391

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.232

Low

255272

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

262336

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.232

Low

1451746

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025