Protein: MED22
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)

Gene: MED22
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q15528

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1149708

MED18
Mediator of RNA polymerase II transcription subunit 18

6

1

Small-scale

0.950

High

1149714

MED17
Mediator of RNA polymerase II transcription subunit 17

6

1

Small-scale

0.945

High

1149702

MED30
Mediator of RNA polymerase II transcription subunit 30

5

1

Small-scale

0.935

High

1149718

MED11
Mediator of RNA polymerase II transcription subunit 11

4

2

Small-scale

0.911

High

1149710

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

Small-scale

0.897

High

287790

MED6
Mediator of RNA polymerase II transcription subunit 6

3

3

High-throughput

0.861

High

1149700

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

High-throughput

0.861

High

881529

CDK8
Cyclin-dependent kinase 8

9

3

Small-scale

0.752

High

1149709

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

666834

CCNC
Cyclin-C

6

1

High-throughput

0.729

High

1149690

MED27
Mediator of RNA polymerase II transcription subunit 27

5

1

Small-scale

0.721

High

1149713

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.718

High

48960

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.717

High

1149707

MED10
Mediator of RNA polymerase II transcription subunit 10

8

0

Small-scale

0.717

High

1149715

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.705

High

1149716

MED29
Mediator of RNA polymerase II transcription subunit 29

6

0

Small-scale

0.702

High

1149712

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.699

High

1149684

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.699

High

1108345

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

219487

MED7
Mediator of RNA polymerase II transcription subunit 7

5

0

Small-scale

0.689

High

1149698

MED12
Mediator of RNA polymerase II transcription subunit 12

4

2

High-throughput

0.686

High

239579

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

High-throughput

0.667

High

335988

MED26
Mediator of RNA polymerase II transcription subunit 26

3

1

High-throughput

0.667

High

1149692

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

1

High-throughput

0.667

High

1149719

MED13
Mediator of RNA polymerase II transcription subunit 13

3

1

High-throughput

0.662

High

1149723

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

High-throughput

0.646

High

282382

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

High-throughput

0.638

High

1149722

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.638

High

1149694

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.611

High

1149703

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.611

High

155759

TXND9
Thioredoxin domain-containing protein 9

2

1

High-throughput

0.606

High

188681

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

1149724

FBX7
F-box only protein 7

2

0

High-throughput

0.592

High

621647

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

912179

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

1149721

MED23
Mediator of RNA polymerase II transcription subunit 23

2

0

High-throughput

0.585

High

259996

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

1149701

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1149705

DCTN5
Dynactin subunit 5

1

1

High-throughput

0.536

High

192817

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

872357

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

1149693

MED25
Mediator of RNA polymerase II transcription subunit 25

1

0

High-throughput

0.513

High

1149706

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.513

High

1149720

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.513

High

843582

HD
Huntingtin

1

0

High-throughput

0.493

High

954479

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

1149689

THOC7
THO complex subunit 7

1

0

Small-scale

0.480

High

143008

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

404074

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

474004

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

520075

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

674169

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.479

High

1087752

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1149685

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1149686

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

283481

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.458

High

621882

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.458

High

667311

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

722969

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

787748

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

830797

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

912062

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

919983

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

976092

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

1088850

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1149691

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1149695

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1149699

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1149704

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1149687

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1149711

CENPH
Centromere protein H

1

0

High-throughput

0.426

High

76424

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

95745

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

886885

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

352626

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

169563

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

1149696

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.282

High

133356

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.279

Low

298174

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

1149697

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1149717

ARP10
Actin-related protein 10

1

0

High-throughput

0.279

Low

301434

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1149688

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025