Protein: SIK3
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)

Gene: SIK3
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q9Y2K2

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

883243

SIK1
Serine/threonine-protein kinase SIK1

2

18

High-throughput

0.811

High

568839

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

2

13

High-throughput

0.793

High

927683

1433Z
14-3-3 protein zeta/delta

5

20

Small-scale

0.726

High

910187

1433E
14-3-3 protein epsilon

4

20

Small-scale

0.694

High

982643

1433F
14-3-3 protein eta

4

20

Small-scale

0.694

High

432384

HS90A
Heat shock protein HSP 90-alpha

1

12

High-throughput

0.691

High

438641

HS90B
Heat shock protein HSP 90-beta

1

12

High-throughput

0.691

High

1035062

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.691

High

1273247

TNPO1
Transportin-1

1

1

High-throughput

0.691

High

1316239

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.691

High

683838

1433B
14-3-3 protein beta/alpha

3

20

Small-scale

0.671

High

819183

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

3

12

High-throughput

0.667

High

994124

PP2BA
Protein phosphatase 3 catalytic subunit alpha

3

10

High-throughput

0.667

High

1076574

TRIP6
Thyroid receptor-interacting protein 6

2

3

High-throughput

0.640

High

647402

1433T
14-3-3 protein theta

2

20

Small-scale

0.621

High

1297570

CANB2
Calcineurin subunit B type 2

1

10

High-throughput

0.618

High

1318015

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.618

High

201476

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.618

High

398146

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.618

High

1025243

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

17

Small-scale

0.618

High

1172341

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

684412

1433S
14-3-3 protein sigma

2

20

Small-scale

0.584

High

1023841

TRAF1
TNF receptor-associated factor 1

1

6

High-throughput

0.573

High

905284

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

573536

TCPA
T-complex protein 1 subunit alpha

1

7

High-throughput

0.536

High

709121

MCM7
DNA replication licensing factor MCM7

1

3

High-throughput

0.536

High

821470

TCPE
T-complex protein 1 subunit epsilon

1

8

High-throughput

0.536

High

826947

TCPG
T-complex protein 1 subunit gamma

1

8

High-throughput

0.536

High

843104

TCPQ
T-complex protein 1 subunit theta

1

10

High-throughput

0.536

High

843438

TCPD
T-complex protein 1 subunit delta

1

6

High-throughput

0.536

High

847120

SMCA4
Transcription activator BRG1

1

2

High-throughput

0.536

High

929733

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.536

High

943548

TCPB
T-complex protein 1 subunit beta

1

8

High-throughput

0.536

High

1306748

TCPH
T-complex protein 1 subunit eta

1

8

High-throughput

0.536

High

1332798

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1347429

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1357482

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.536

High

950333

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.515

High

1078701

SMAD2
Mothers against decapentaplegic homolog 2

1

3

Small-scale

0.515

High

792108

HD
Huntingtin

1

1

High-throughput

0.515

High

1059952

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.513

High

1120159

CRTC2
CREB-regulated transcription coactivator 2

1

6

Small-scale

0.501

High

1357900

HDAC5
Histone deacetylase 5

1

12

Small-scale

0.501

High

168991

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.489

High

685124

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.489

High

725613

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.489

High

1069571

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.489

High

1272280

GSLG1
Golgi apparatus protein 1

1

1

High-throughput

0.489

High

1377291

SGT1
Protein SGT1 homolog

1

2

High-throughput

0.489

High

377817

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

815306

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

1348533

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.479

High

497840

TAU
Microtubule-associated protein tau

1

10

Small-scale

0.445

High

1334611

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

101300

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

164510

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.437

High

352319

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

1183053

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.437

High

1245047

NEUA
N-acylneuraminate cytidylyltransferase

1

1

High-throughput

0.437

High

1291745

BICD1
Protein bicaudal D homolog 1

1

11

High-throughput

0.437

High

61505

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.279

Low

150280

AP3D1
AP-3 complex subunit delta-1

1

0

High-throughput

0.279

Low

224668

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.279

Low

873773

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1335140

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.279

Low

1343968

SAS10
Something about silencing protein 10

1

0

High-throughput

0.279

Low

1122776

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.269

Low

335699

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024