Protein: CPNE2
Copine-2 (Copine II)

Gene: CPNE2
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q96FN4

Gene Ontology (top 5):
GO:0005544 - calcium-dependent phospholipid binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

250312

VINEX
Vinexin

3

4

High-throughput

0.871

High

1390827

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.742

High

572128

TRI27
Zinc finger protein RFP

4

2

High-throughput

0.700

High

1048960

REL
Proto-oncogene c-Rel

3

1

High-throughput

0.675

High

1348707

UBA3
NEDD8-activating enzyme E1 catalytic subunit

3

2

High-throughput

0.675

High

135680

DNM1L
Dynamin-1-like protein

3

1

High-throughput

0.662

High

1390831

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

3

3

High-throughput

0.662

High

1390817

OSBL3
Oxysterol-binding protein-related protein 3

3

0

High-throughput

0.634

High

131004

HIP1
Huntingtin-interacting protein 1

2

2

High-throughput

0.628

High

188020

EIF3H
Eukaryotic translation initiation factor 3 subunit H

2

5

High-throughput

0.628

High

821175

TXLNA
Alpha-taxilin

2

6

High-throughput

0.628

High

908440

HDGF
Hepatoma-derived growth factor

2

2

High-throughput

0.628

High

908887

NEK3
Serine/threonine-protein kinase Nek3

2

3

High-throughput

0.628

High

936410

AFAD
Afadin

2

11

High-throughput

0.628

High

1121844

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

2

High-throughput

0.628

High

1390811

NEK1
Serine/threonine-protein kinase Nek1

2

5

High-throughput

0.628

High

1390818

COE3
Transcription factor COE3

2

2

High-throughput

0.628

High

1338672

T185A
Transmembrane protein 185A

3

1

High-throughput

0.609

High

1361446

THAP4
Peroxynitrite isomerase THAP4

3

1

High-throughput

0.607

High

1390824

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1390819

RABE2
Rab GTPase-binding effector protein 2

3

5

High-throughput

0.604

High

1390829

RABX5
Rab5 GDP/GTP exchange factor

3

1

High-throughput

0.604

High

192841

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

667402

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.602

High

912212

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.602

High

1229188

INT3
Integrator complex subunit 3

2

0

High-throughput

0.602

High

1313028

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.602

High

1361130

PIBF1
Progesterone-induced-blocking factor 1

2

0

High-throughput

0.602

High

1390832

NOC2L
Nucleolar complex protein 2 homolog

2

0

High-throughput

0.602

High

130574

SPT5H
Transcription elongation factor SPT5

2

3

High-throughput

0.601

High

587181

ITF2
Transcription factor 4

2

0

High-throughput

0.580

High

1356620

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.580

High

1390816

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.580

High

271286

CPNE3
Copine-3

1

15

High-throughput

0.575

High

1231948

MRCKG
Serine/threonine-protein kinase MRCK gamma

1

3

High-throughput

0.575

High

1390825

TXLNG
Gamma-taxilin

2

4

High-throughput

0.574

High

1390826

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.573

High

1348418

LNX1
E3 ubiquitin-protein ligase LNX

1

7

High-throughput

0.573

High

1390833

NEMO
NF-kappa-B essential modulator

1

4

High-throughput

0.561

High

1390823

ANLN
Anillin

2

2

High-throughput

0.558

High

1206420

EFHC2
EF-hand domain-containing family member C2

2

1

High-throughput

0.553

High

48053

RBM47
RNA-binding protein 47

1

3

High-throughput

0.536

High

756302

MCM7
DNA replication licensing factor MCM7

1

8

High-throughput

0.536

High

789196

NUP62
Nuclear pore glycoprotein p62

1

5

High-throughput

0.536

High

1229153

FRPD2
FERM and PDZ domain-containing protein 2

1

2

High-throughput

0.536

High

1370286

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.536

High

1371497

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.536

High

1390815

CNTP3
Contactin-associated protein-like 3

1

1

High-throughput

0.536

High

1232516

Q6FHY5
MEOX2 protein

1

4

High-throughput

0.515

High

723046

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

787769

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

1033141

EWS
RNA-binding protein EWS

1

0

High-throughput

0.513

High

1334764

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1337189

POPD1
Popeye domain-containing protein 1

1

0

High-throughput

0.513

High

1357974

RN138
E3 ubiquitin-protein ligase RNF138

1

0

High-throughput

0.513

High

1390810

ZN317
Zinc finger protein 317

1

0

High-throughput

0.513

High

1390822

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

1390830

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.513

High

628005

ANXA7
Annexin A7

1

3

High-throughput

0.508

High

808141

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.508

High

1315322

ZDH23
Palmitoyltransferase ZDHHC23

1

2

High-throughput

0.489

High

1390820

SYNCI
Syncoilin

1

1

High-throughput

0.489

High

894088

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.481

High

347865

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

372825

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

406494

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

862367

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

888250

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

1086285

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

1255033

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1291129

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.479

High

1390828

SEPT9
Septin-9

1

0

Small-scale

0.458

High

430230

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

537699

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.445

High

564199

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

862690

UTRN
Utrophin

1

5

High-throughput

0.445

High

1272858

TAOK1
Serine/threonine-protein kinase TAO1

1

2

High-throughput

0.445

High

1357878

CTF18
Chromosome transmission fidelity protein 18 homolog

1

2

High-throughput

0.445

High

884382

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

4

High-throughput

0.437

High

517491

GLI2
Zinc finger protein GLI2

1

0

High-throughput

0.426

High

583883

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

High-throughput

0.426

High

1092619

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

505967

MYZAP
Myocardial zonula adherens protein

1

4

High-throughput

0.407

High

1156571

CCDC6
Coiled-coil domain-containing protein 6

1

5

High-throughput

0.407

High

1390813

DCC1
Sister chromatid cohesion protein DCC1

1

1

High-throughput

0.407

High

1216189

DDI2
Protein DDI1 homolog 2

3

0

High-throughput

0.345

High

1276143

NUP54
Nucleoporin p54

3

0

High-throughput

0.345

High

1390814

NUP58
Nucleoporin p58/p45

3

0

High-throughput

0.345

High

1218212

ZN318
Zinc finger protein 318

2

0

High-throughput

0.328

High

1390821

ZDBF2
DBF4-type zinc finger-containing protein 2

2

0

High-throughput

0.328

High

71522

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

1331398

GBP7
Guanylate-binding protein 7

2

0

High-throughput

0.316

High

1232001

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

0

High-throughput

0.305

High

1325592

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

0

High-throughput

0.279

Low

1366358

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.279

Low

1390809

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

1390812

APC13
Anaphase-promoting complex subunit 13

1

0

High-throughput

0.279

Low

418349

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

506018

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

506705

CTF8
Chromosome transmission fidelity protein 8 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025