Protein: LCE4A
Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A)

Gene: LCE4A
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q5TA78

Gene Ontology (top 5):
GO:0031424 - keratinization
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

950788

KR109
Keratin-associated protein 10-9

4

19

High-throughput

0.639

High

1215120

KRA92
Keratin-associated protein 9-2

3

20

High-throughput

0.619

High

303147

RGS20
Regulator of G-protein signaling 20

3

2

High-throughput

0.616

High

685874

KRA59
Keratin-associated protein 5-9

3

20

High-throughput

0.616

High

885282

HXA1
Homeobox protein Hox-A1

3

1

High-throughput

0.616

High

950281

KR107
Keratin-associated protein 10-7

3

17

High-throughput

0.616

High

950520

KR108
Keratin-associated protein 10-8

3

17

High-throughput

0.616

High

1215114

KR412
Keratin-associated protein 4-12

3

20

High-throughput

0.616

High

1215124

KRA42
Keratin-associated protein 4-2

3

20

High-throughput

0.616

High

1215126

KRA32
Keratin-associated protein 3-2

3

2

High-throughput

0.616

High

1213895

LCE1C
Late cornified envelope protein 1C

2

2

High-throughput

0.606

High

1213980

LCE1E
Late cornified envelope protein 1E

2

1

High-throughput

0.606

High

1214297

LCE1B
Late cornified envelope protein 1B

2

1

High-throughput

0.606

High

1215095

LCE2C
Late cornified envelope protein 2C

2

2

High-throughput

0.606

High

159062

LCE2B
Late cornified envelope protein 2B

2

0

High-throughput

0.580

High

652329

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.580

High

1214254

LCE1A
Late cornified envelope protein 1A

2

0

High-throughput

0.580

High

1215093

LCE4A
Late cornified envelope protein 4A

2

0

High-throughput

0.580

High

1215097

LCE5A
Late cornified envelope protein 5A

2

0

High-throughput

0.580

High

221364

SPY1
Protein sprouty homolog 1

2

1

High-throughput

0.553

High

890631

RGS19
Regulator of G-protein signaling 19

2

2

High-throughput

0.553

High

949561

KR123
Keratin-associated protein 12-3

2

1

High-throughput

0.553

High

950166

KR106
Keratin-associated protein 10-6

2

17

High-throughput

0.553

High

1059657

KRA11
Keratin-associated protein 1-1

2

18

High-throughput

0.553

High

1215099

KR511
Keratin-associated protein 5-11

2

18

High-throughput

0.553

High

1215100

KRA57
Keratin-associated protein 5-7

2

16

High-throughput

0.553

High

1215102

KRA54
Keratin-associated protein 5-4

2

13

High-throughput

0.553

High

1215103

KRA53
Keratin-associated protein 5-3

2

16

High-throughput

0.553

High

1215109

KRA13
Keratin-associated protein 1-3

2

18

High-throughput

0.553

High

1215117

KRA98
Keratin-associated protein 9-8

2

20

High-throughput

0.553

High

1215119

KRA93
Keratin-associated protein 9-3

2

20

High-throughput

0.553

High

1215121

KR411
Keratin-associated protein 4-11

2

20

High-throughput

0.553

High

1215122

KRA45
Keratin-associated protein 4-5

2

20

High-throughput

0.553

High

1215123

KRA44
Keratin-associated protein 4-4

2

20

High-throughput

0.553

High

1215125

KRA33
Keratin-associated protein 3-3

2

2

High-throughput

0.553

High

1215127

KRA31
Keratin-associated protein 3-1

2

2

High-throughput

0.553

High

1215128

KRA15
Keratin-associated protein 1-5

2

20

High-throughput

0.553

High

1215130

PLS3
Phospholipid scramblase 3

2

1

High-throughput

0.553

High

180535

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.523

High

221142

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.523

High

948338

KR122
Keratin-associated protein 12-2

1

20

High-throughput

0.523

High

1215118

KRA94
Keratin-associated protein 9-4

1

20

High-throughput

0.523

High

1215131

RGS17
Regulator of G-protein signaling 17

1

2

High-throughput

0.523

High

1215033

LCE3A
Late cornified envelope protein 3A

1

1

High-throughput

0.481

High

1215094

LCE2A
Late cornified envelope protein 2A

1

1

High-throughput

0.481

High

1215096

LCE2D
Late cornified envelope protein 2D

1

2

High-throughput

0.481

High

517028

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

950073

KR105
Keratin-associated protein 10-5

1

19

High-throughput

0.470

High

1212895

LCE3C
Late cornified envelope protein 3C

1

0

High-throughput

0.460

High

1213937

LCE1D
Late cornified envelope protein 1D

1

0

High-throughput

0.460

High

1214017

LCE1F
Late cornified envelope protein 1F

1

0

High-throughput

0.460

High

949714

KR101
Keratin-associated protein 10-1

1

19

High-throughput

0.439

High

1215107

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.439

High

892210

MCSP
Sperm mitochondrial-associated cysteine-rich protein

3

0

High-throughput

0.352

High

1215104

ATL4
ADAMTS-like protein 4

3

0

High-throughput

0.352

High

1215113

MDFI
MyoD family inhibitor

3

0

High-throughput

0.352

High

70268

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.320

High

705391

GRN
Progranulin

2

0

High-throughput

0.320

High

165180

TSN4
Tetraspanin-4

2

0

High-throughput

0.316

High

452286

PDIA1
Protein disulfide-isomerase

2

0

High-throughput

0.316

High

949658

KR124
Keratin-associated protein 12-4

2

0

High-throughput

0.316

High

1039757

CREB5
Cyclic AMP-responsive element-binding protein 5

2

0

High-throughput

0.316

High

1180098

VWC2
Brorin

2

0

High-throughput

0.316

High

1215098

VASN
Vasorin

2

0

High-throughput

0.316

High

1215101

KRA56
Keratin-associated protein 5-6

2

0

High-throughput

0.316

High

1215110

TRI42
Tripartite motif-containing protein 42

2

0

High-throughput

0.316

High

1215111

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

1215112

S39A7
Zinc transporter SLC39A7

2

0

High-throughput

0.316

High

1215115

FUCO2
Plasma alpha-L-fucosidase

2

0

High-throughput

0.316

High

1215116

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.316

High

1215129

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

0

High-throughput

0.316

High

1215132

CRCT1
Cysteine-rich C-terminal protein 1

2

0

High-throughput

0.316

High

733160

OTX1
Homeobox protein OTX1

1

0

High-throughput

0.299

High

893917

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.299

High

1145976

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.299

High

1215105

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.299

High

542

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

426099

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.251

Low

1215106

KRA52
Keratin-associated protein 5-2

1

0

High-throughput

0.251

Low

1215108

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025