Protein: ZBP1
Z-DNA-binding protein 1 (DNA-dependent activator of IFN-regulatory factors) (DAI) (Tumor stroma and activated macrophage protein DLM-1)

Gene: ZBP1
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q9H171

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0003677 - DNA binding
GO:0003692 - left-handed Z-DNA binding
GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1430851

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

4

3

Small-scale

0.878

High

1430845

ZBP1
Z-DNA-binding protein 1

2

1

Small-scale

0.776

High

1109662

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

4

4

Small-scale

0.674

High

941551

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.578

High

1103367

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.578

High

1094980

TRAF3
TNF receptor-associated factor 3

1

0

High-throughput

0.554

High

1418710

TRI34
E3 ubiquitin-protein ligase TRIM34

1

0

Small-scale

0.554

High

1430850

PALD
Paladin

1

0

High-throughput

0.554

High

338187

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.513

High

828951

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1336946

ZN740
Zinc finger protein 740

1

0

High-throughput

0.513

High

246936

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.493

High

1365813

ZN516
Zinc finger protein 516

1

0

High-throughput

0.493

High

1400918

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.493

High

1430849

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.493

High

843971

HD
Huntingtin

1

0

High-throughput

0.493

High

1151646

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.481

High

1199035

KLH12
Kelch-like protein 12

1

1

High-throughput

0.481

High

1307792

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

High-throughput

0.481

High

167971

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

1

Small-scale

0.479

High

193046

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

Small-scale

0.479

High

214030

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

1132433

CASP8
Caspase-8

1

1

Small-scale

0.479

High

1418797

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

Small-scale

0.479

High

1429978

SHRPN
Sharpin

1

1

Small-scale

0.479

High

927539

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

1035907

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1056965

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.458

High

1107479

BIRC2
Baculoviral IAP repeat-containing protein 2

1

0

Small-scale

0.458

High

1140835

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1332989

MLKL
Mixed lineage kinase domain-like protein

1

0

Small-scale

0.458

High

1384818

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1389380

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

Small-scale

0.458

High

1391757

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

1430846

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1430847

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1430848

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

166697

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

High-throughput

0.437

High

1112171

KRR1
KRR1 small subunit processome component homolog

1

0

Small-scale

0.426

High

116354

H3BTL2
Protein-serine/threonine kinase

1

1

High-throughput

0.407

High

1249634

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.301

High

554839

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1419879

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025