Protein: ORC3
Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo)

Gene: ORC3
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9UBD5

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104374

ORC2
Origin recognition complex subunit 2

13

4

Small-scale

0.982

High

1104333

ORC1
Origin recognition complex subunit 1

7

13

Small-scale

0.965

High

230925

ORC5
Origin recognition complex subunit 5

6

18

Small-scale

0.945

High

231526

ORC4
Origin recognition complex subunit 4

6

13

Small-scale

0.935

High

1458321

ORC6
Origin recognition complex subunit 6

5

2

Small-scale

0.722

High

1406954

CDC6
Cell division control protein 6 homolog

1

12

High-throughput

0.692

High

1434838

STN1
CST complex subunit STN1

3

0

High-throughput

0.638

High

980477

H4
Histone H4

3

1

High-throughput

0.631

High

756389

MCM7
DNA replication licensing factor MCM7

2

2

Small-scale

0.614

High

1458315

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

0

Small-scale

0.585

High

397126

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1219901

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.537

High

355354

CCNE2
G1/S-specific cyclin-E2

1

2

High-throughput

0.536

High

1272268

MCM10
Protein MCM10 homolog

1

1

High-throughput

0.536

High

133139

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.536

High

1091365

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.536

High

1420512

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.536

High

1458320

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.536

High

281260

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.513

High

920330

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

1111330

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1150266

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

1253808

QSOX2
Sulfhydryl oxidase 2

1

0

High-throughput

0.513

High

1404470

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1413472

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

Small-scale

0.513

High

288530

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

1

Small-scale

0.501

High

756076

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.501

High

853426

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.501

High

799540

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.493

High

1430849

ZBP1
Z-DNA-binding protein 1

1

0

High-throughput

0.493

High

1458317

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

755810

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.481

High

964487

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1150013

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.480

High

1458318

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

1089588

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.479

High

404507

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

419251

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

487844

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

558463

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

559529

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

755014

H2B1B
Histone H2B type 1-B

1

3

High-throughput

0.479

High

883723

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

981154

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

1097605

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

1129770

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1260633

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.479

High

1367482

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1401423

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

1436817

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.479

High

248124

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

260566

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

316106

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

373384

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

589930

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696749

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769406

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

879569

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

1005202

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1114531

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1140980

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1155857

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1276905

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1329919

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1387615

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1415895

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1452450

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1453011

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1458316

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1458319

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1209753

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1162065

H31T
Histone H3.1t

1

2

High-throughput

0.408

High

887290

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1458322

SNX11
Sorting nexin-11

3

0

High-throughput

0.347

High

1369268

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

0

High-throughput

0.328

High

182815

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

1060582

KLC1
Kinesin light chain 1

1

0

High-throughput

0.279

Low

1158832

CART

1

0

High-throughput

0.279

Low

1254141

CAN12
Calpain-12

1

0

High-throughput

0.279

Low

1287789

NOP9
Nucleolar protein 9

1

0

High-throughput

0.279

Low

1369542

KIFA3
Kinesin-associated protein 3

1

0

High-throughput

0.279

Low

1398896

RILP
Rab-interacting lysosomal protein

1

0

High-throughput

0.279

Low

1414168

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1452173

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

High-throughput

0.279

Low

1453820

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

1458323

TACC3
Transforming acidic coiled-coil-containing protein 3

1

0

High-throughput

0.279

Low

423375

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

157948

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

400033

CATA
Catalase

1

0

High-throughput

0.249

Low

412742

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1255919

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1360836

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

1434124

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1094997

TRAF3
TNF receptor-associated factor 3

1

0

High-throughput

0.232

Low

1180754

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025