Protein: PE2R4
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)

Gene: PE2R4, PTGER4
Organism: Homo sapiens
Interactions: 47
UniProt ID: P35408

Gene Ontology (top 5):
GO:0001818 - negative regulation of cytokine production
GO:0001819 - positive regulation of cytokine production
GO:0004957 - prostaglandin E receptor activity
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

771057

ARRB1
Beta-arrestin-1

1

12

Small-scale

0.691

High

771078

VTM2A
V-set and transmembrane domain-containing protein 2A

1

0

High-throughput

0.663

High

732447

ARRB2
Beta-arrestin-2

1

12

Small-scale

0.618

High

557141

SRC
Proto-oncogene tyrosine-protein kinase Src

2

7

Small-scale

0.601

High

771083

FEM1A
Protein fem-1 homolog A

1

1

Small-scale

0.552

High

138455

BIN1
Myc box-dependent-interacting protein 1

1

1

High-throughput

0.541

High

224638

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.541

High

483884

HMOX1
Heme oxygenase 1

1

3

High-throughput

0.541

High

614660

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

High-throughput

0.541

High

719863

HMOX2
Heme oxygenase 2

1

3

High-throughput

0.541

High

771059

NU153
Nuclear pore complex protein Nup153

1

1

High-throughput

0.541

High

771065

DYST
Dystonin

1

4

High-throughput

0.541

High

771067

KLC1
Kinesin light chain 1

1

1

High-throughput

0.541

High

771068

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.541

High

771075

PPR3F
Protein phosphatase 1 regulatory subunit 3F

1

1

High-throughput

0.541

High

771085

S39A8
Metal cation symporter ZIP8

1

10

High-throughput

0.541

High

771086

T161A
Transmembrane protein 161A

1

1

High-throughput

0.541

High

771087

ATX10
Ataxin-10

1

1

High-throughput

0.541

High

771089

CTND2
Catenin delta-2

1

4

High-throughput

0.541

High

771090

NISCH
Nischarin

1

6

High-throughput

0.541

High

771063

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.518

High

771064

CRADD
Death domain-containing protein CRADD

1

0

High-throughput

0.518

High

771076

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.518

High

771077

WDR19
WD repeat-containing protein 19

1

0

High-throughput

0.518

High

123227

PDLI1
PDZ and LIM domain protein 1

1

20

High-throughput

0.494

High

281902

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.494

High

771060

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.494

High

771066

PRDX1
Peroxiredoxin-1

1

3

High-throughput

0.494

High

771072

CXG2
Gap junction gamma-2 protein

1

4

High-throughput

0.494

High

771079

DPF1
Zinc finger protein neuro-d4

1

1

High-throughput

0.494

High

771081

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

High-throughput

0.494

High

771091

SGT1
Protein SGT1 homolog

1

2

High-throughput

0.494

High

771092

ZN337
Zinc finger protein 337

1

1

High-throughput

0.494

High

771058

PSN1
Presenilin-1

1

0

Small-scale

0.458

High

522246

OSTP
Osteopontin

1

0

High-throughput

0.282

High

771061

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.282

High

771069

SEC20
Vesicle transport protein SEC20

1

0

High-throughput

0.282

High

771070

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.282

High

771071

CRY2
Cryptochrome-2

1

0

High-throughput

0.282

High

771073

RN220
E3 ubiquitin-protein ligase RNF220

1

0

High-throughput

0.282

High

771074

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

1

0

High-throughput

0.282

High

771080

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

1

0

High-throughput

0.282

High

771082

HOP
Homeodomain-only protein

1

0

High-throughput

0.282

High

771084

RTF2
Replication termination factor 2

1

0

High-throughput

0.282

High

771088

APC7
Anaphase-promoting complex subunit 7

1

0

High-throughput

0.282

High

771093

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.282

High

771062

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025