Protein: HACD3
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)

Gene: HACD3
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q9P035

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005925 - focal adhesion
GO:0007249 - canonical NF-kappaB signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

529822

CFTR
Cystic fibrosis transmembrane conductance regulator

4

3

High-throughput

0.678

High

228934

PRKN
E3 ubiquitin-protein ligase parkin

3

4

High-throughput

0.640

High

1349536

VAPA
Vesicle-associated membrane protein-associated protein A

2

2

Small-scale

0.611

High

123744

PGRC1
Membrane-associated progesterone receptor component 1

2

0

Small-scale

0.585

High

1316784

ACE2
Angiotensin-converting enzyme 2

3

1

Small-scale

0.585

High

323237

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

848574

CAV2
Caveolin-2

2

1

High-throughput

0.571

High

1062020

RHG19
Rho GTPase-activating protein 19

2

3

High-throughput

0.571

High

1130675

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

411512

INSR
Insulin receptor

2

8

Small-scale

0.549

High

1224238

DOCK3
Dedicator of cytokinesis protein 3

2

0

High-throughput

0.547

High

385633

NTRK1
High affinity nerve growth factor receptor

2

6

High-throughput

0.543

High

370591

ESR1
Estrogen receptor

1

9

High-throughput

0.536

High

654855

CALX
Calnexin

1

2

High-throughput

0.536

High

714700

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.536

High

847701

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.536

High

891345

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.536

High

990720

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.536

High

1121719

RHG15
Rho GTPase-activating protein 15

1

3

High-throughput

0.536

High

206091

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.533

High

1042708

CUL3
Cullin-3

2

2

High-throughput

0.533

High

1146908

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.533

High

1200870

PAQR2
Adiponectin receptor protein 2

2

2

Small-scale

0.533

High

763120

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

834362

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

1235336

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.513

High

1328620

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

879857

TPTE
Putative tyrosine-protein phosphatase TPTE

1

2

High-throughput

0.506

High

987303

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

8

High-throughput

0.500

High

1088149

DDR2
Discoidin domain-containing receptor 2

1

7

High-throughput

0.500

High

1291489

TSN17
Tetraspanin-17

1

0

High-throughput

0.493

High

1313323

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.493

High

175265

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.489

High

858678

PPP5
Serine/threonine-protein phosphatase 5

1

3

High-throughput

0.489

High

903564

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.489

High

921068

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.489

High

1067637

P2RY6
P2Y purinoceptor 6

1

5

High-throughput

0.489

High

1253917

SPP2B
Signal peptide peptidase-like 2B

1

3

High-throughput

0.489

High

1267202

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.489

High

1329917

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.489

High

48543

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

120681

RHOD
Rho-related GTP-binding protein RhoD

1

11

High-throughput

0.479

High

159409

PLD2
Phospholipase D2

1

2

High-throughput

0.479

High

164020

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.479

High

168066

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

169642

BET1
BET1 homolog

1

2

High-throughput

0.479

High

196359

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

Small-scale

0.479

High

298846

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

310848

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

Small-scale

0.479

High

329983

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

375005

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

387637

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

390584

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

391222

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

436547

RHOC
Rho-related GTP-binding protein RhoC

1

9

High-throughput

0.479

High

545665

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

561701

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

4

High-throughput

0.479

High

587733

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.479

High

719202

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

787178

RHG25
Rho GTPase-activating protein 25

1

2

High-throughput

0.479

High

830302

CASP4
Caspase-4

1

4

High-throughput

0.479

High

892640

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

894526

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

900988

RHOA
Transforming protein RhoA

1

10

High-throughput

0.479

High

916032

RHOB
Rho-related GTP-binding protein RhoB

1

10

High-throughput

0.479

High

925679

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

999155

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1036158

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1053233

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

10

Small-scale

0.479

High

1076791

RHOH
Rho-related GTP-binding protein RhoH

1

10

High-throughput

0.479

High

1101588

RHG31
Rho GTPase-activating protein 31

1

2

High-throughput

0.479

High

1148248

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.479

High

1166015

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1169988

RHG36
Rho GTPase-activating protein 36

1

3

High-throughput

0.479

High

1217111

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1240342

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1240814

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.479

High

1251933

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.479

High

1255709

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1269794

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1281437

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

1286090

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.479

High

1294086

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1302777

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

1303607

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

1335353

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

1349019

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1349539

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.479

High

1349544

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1038105

SERC3
Serine incorporator 3

1

1

High-throughput

0.470

High

1334982

BRF2
Transcription factor IIIB 50 kDa subunit

1

1

High-throughput

0.470

High

1335903

NEK6
Serine/threonine-protein kinase Nek6

1

4

High-throughput

0.470

High

119546

LEG9
Galectin-9

1

0

High-throughput

0.458

High

507280

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

553925

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

795315

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

825579

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

833361

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.458

High

845778

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.458

High

873162

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.458

High

897193

TM258
Transmembrane protein 258

1

0

High-throughput

0.458

High

961865

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

1030650

CLN3
Battenin

1

0

Small-scale

0.458

High

1124463

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

1140818

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1313085

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1348599

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

435785

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.457

High

665673

EPHB2
Ephrin type-B receptor 2

1

5

High-throughput

0.457

High

1081630

NTRK3
NT-3 growth factor receptor

1

6

High-throughput

0.457

High

1315375

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

1349540

KLF15
Krueppel-like factor 15

1

1

High-throughput

0.457

High

402561

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

497699

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1328051

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

1330648

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

256114

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

260623

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.437

High

295334

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

302025

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.437

High

320232

ERR2
Steroid hormone receptor ERR2

1

7

High-throughput

0.437

High

398119

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.437

High

488820

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.437

High

509740

UBL4A
Ubiquitin-like protein 4A

1

3

High-throughput

0.437

High

548759

VAV
Proto-oncogene vav

1

1

High-throughput

0.437

High

588681

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

6

High-throughput

0.437

High

591429

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.437

High

665537

EPHA8
Ephrin type-A receptor 8

1

3

High-throughput

0.437

High

685066

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.437

High

718534

NOS2
Nitric oxide synthase, inducible

1

2

High-throughput

0.437

High

780231

CCNF
Cyclin-F

1

2

High-throughput

0.437

High

824474

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

828036

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.437

High

870914

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

909248

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

941523

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

961302

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.437

High

965870

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

983254

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.437

High

1035027

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.437

High

1049666

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.437

High

1064788

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

1077353

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.437

High

1116594

LARP7
La-related protein 7

1

1

High-throughput

0.437

High

1119649

MIDN
Midnolin

1

1

High-throughput

0.437

High

1138667

ARHGG
Rho guanine nucleotide exchange factor 16

1

1

High-throughput

0.437

High

1148830

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

1156737

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1159310

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.437

High

1166877

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1172047

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1188965

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1192606

FLIP1
Filamin-A-interacting protein 1

1

2

High-throughput

0.437

High

1199701

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.437

High

1201729

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

1204852

GOLI
E3 ubiquitin-protein ligase RNF130

1

4

High-throughput

0.437

High

1216851

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.437

High

1221793

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.437

High

1222115

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.437

High

1256444

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

1270213

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

2

High-throughput

0.437

High

1292263

AURKB
Aurora kinase B

1

3

High-throughput

0.437

High

1292888

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

1296754

RHOV
Rho-related GTP-binding protein RhoV

1

8

High-throughput

0.437

High

1304946

NECD
Necdin

1

3

High-throughput

0.437

High

1315891

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

1319093

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.437

High

1329103

VP33B
Vacuolar protein sorting-associated protein 33B

1

2

High-throughput

0.437

High

1331492

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1333724

AKTIP
AKT-interacting protein

1

3

Small-scale

0.437

High

1335212

RC3H2
Roquin-2

1

1

High-throughput

0.437

High

1342806

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.437

High

1349537

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

1349538

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

1349543

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

1349545

E41L3
Band 4.1-like protein 3

1

2

High-throughput

0.437

High

1349546

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

1036956

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

1282494

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.426

High

1283309

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.426

High

92804

E9PS44
Interferon induced transmembrane protein 3

1

3

High-throughput

0.407

High

99691

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.407

High

240224

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

306341

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.407

High

384007

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.407

High

625620

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.407

High

709088

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.407

High

924912

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.407

High

1200014

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.407

High

927890

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

0

High-throughput

0.305

High

1061653

CUL7
Cullin-7

2

0

High-throughput

0.305

High

1349542

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

1310735

PELO
Protein pelota homolog

1

0

High-throughput

0.269

Low

643409

HMGB2
High mobility group protein B2

1

0

High-throughput

0.265

Low

123053

MEN1
Menin

1

0

High-throughput

0.249

Low

326799

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.249

Low

348098

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

541289

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

545052

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

652462

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

718260

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.249

Low

721644

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

742572

SYUA
Alpha-synuclein

1

0

High-throughput

0.249

Low

777277

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.249

Low

829215

SYAC
Alanine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

868351

ATX3
Ataxin-3

1

0

High-throughput

0.249

Low

1045369

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

1049165

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

1053677

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1054635

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

1080415

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1086002

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.249

Low

1135481

CCD18
Coiled-coil domain-containing protein 18

1

0

High-throughput

0.249

Low

1202160

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.249

Low

1230406

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1231497

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1260935

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1299946

FMNL2
Formin-like protein 2

1

0

High-throughput

0.249

Low

1315163

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1327132

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1335504

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

1335683

LFG4
Protein lifeguard 4

1

0

High-throughput

0.249

Low

1343725

ANLN
Anillin

1

0

High-throughput

0.249

Low

1346603

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.249

Low

1347715

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1349541

FBXL2
F-box/LRR-repeat protein 2

1

0

Small-scale

0.249

Low

1349547

5MP1
eIF5-mimic protein 1

1

0

High-throughput

0.249

Low

1147

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1047298

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

1240551

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1329438

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.232

Low

1334579

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024