Protein: TIRR
Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)

Gene: TIRR, NUDT16L1
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q9BRJ7

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0030515 - snoRNA binding
GO:2001033 - negative regulation of double-strand break repair via nonhomologous end joining

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1088996

TP53B
TP53-binding protein 1

5

1

Small-scale

0.935

High

1387364

NUD16
U8 snoRNA-decapping enzyme

3

2

Small-scale

0.861

High

729426

HNRH1
Heterogeneous nuclear ribonucleoprotein H

3

2

High-throughput

0.665

High

384720

CRYAB
Alpha-crystallin B chain

3

0

High-throughput

0.638

High

1090881

TRAF2
TNF receptor-associated factor 2

3

3

High-throughput

0.616

High

913024

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

2

High-throughput

0.606

High

1231190

TRI68
E3 ubiquitin-protein ligase TRIM68

2

1

High-throughput

0.606

High

1411220

TRAF4
TNF receptor-associated factor 4

2

2

High-throughput

0.606

High

1411224

NEK6
Serine/threonine-protein kinase Nek6

2

1

High-throughput

0.606

High

938787

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

2

2

High-throughput

0.601

High

1081457

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1392041

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.580

High

1392866

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1411227

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.580

High

1411229

IKZF3
Zinc finger protein Aiolos

2

0

High-throughput

0.580

High

831322

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

411025

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

0

High-throughput

0.551

High

1112690

CUL1
Cullin-1

1

2

High-throughput

0.536

High

1114136

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1115390

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

485719

RU2A
U2 small nuclear ribonucleoprotein A'

1

1

High-throughput

0.515

High

647640

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.513

High

1115962

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1143855

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.513

High

1154918

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.513

High

1291170

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1370336

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1411233

NGN3
Neurogenin-3

1

0

High-throughput

0.513

High

1411232

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

765837

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

920241

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

1404729

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1243357

Q6P9E2
RECK protein

1

1

High-throughput

0.470

High

125595

LEG9
Galectin-9

1

0

High-throughput

0.458

High

170317

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

320765

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

401388

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

406570

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

473025

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

589542

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696348

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

872686

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

888288

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

905081

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1244822

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1367137

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1411228

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1399998

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

High-throughput

0.457

High

430293

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

352037

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

1

1

High-throughput

0.439

High

292209

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.437

High

1255278

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1260624

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

1390288

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

Small-scale

0.437

High

1411221

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.437

High

1411222

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

1411226

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

414515

P53
Cellular tumor antigen p53

1

0

Small-scale

0.426

High

635373

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.426

High

1235736

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

1

High-throughput

0.407

High

887178

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

889934

VEGFB
Vascular endothelial growth factor B

4

0

High-throughput

0.360

High

1146125

K1H1
Keratin, type I cuticular Ha1

2

0

High-throughput

0.316

High

1411223

MET17
Ribosome assembly protein METTL17, mitochondrial

2

0

High-throughput

0.316

High

1411225

CABP2
Calcium-binding protein 2

2

0

High-throughput

0.316

High

1182860

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

0

High-throughput

0.314

High

1411231

NTNG1
Netrin-G1

2

0

High-throughput

0.313

High

1336454

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.299

High

867384

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

168117

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

0

High-throughput

0.269

Low

422997

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

769021

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

861269

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

879404

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1135071

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1156840

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1162517

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1347853

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.249

Low

328135

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

369740

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.232

Low

1119281

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

1411230

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025