Protein: TIM23
Mitochondrial import inner membrane translocase subunit Tim23

Gene: TIM23, TIMM23
Organism: Homo sapiens
Interactions: 86
UniProt ID: O14925

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005744 - TIM23 mitochondrial import inner membrane translocase complex
GO:0005758 - mitochondrial intermembrane space
GO:0006626 - protein targeting to mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168061

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

3

2

Small-scale

0.858

High

168113

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

168060

MOT2
Monocarboxylate transporter 2

2

1

High-throughput

0.553

High

168133

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.513

High

168118

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

1

Small-scale

0.500

High

168116

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.489

High

168064

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

High-throughput

0.479

High

168067

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

168069

ADT1
ADP/ATP translocase 1

1

3

Small-scale

0.479

High

168093

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

Small-scale

0.479

High

168124

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

168062

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

168084

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

168086

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

168119

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

168121

BRD8
Bromodomain-containing protein 8

1

0

High-throughput

0.458

High

168122

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.458

High

168139

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

168072

RHOQ
Rho-related GTP-binding protein RhoQ

1

1

High-throughput

0.437

High

168097

PKHG4
Puratrophin-1

1

1

High-throughput

0.437

High

168138

FYV1
1-phosphatidylinositol 3-phosphate 5-kinase

1

1

High-throughput

0.437

High

137

A0A024R6X4
PLEKHG4

1

1

High-throughput

0.407

High

96862

E9PDH4
Phosphoinositide kinase, FYVE-type zinc finger containing

1

1

High-throughput

0.407

High

168073

TSN8
Tetraspanin-8

2

0

High-throughput

0.316

High

168087

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

168089

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.316

High

168090

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

168098

RNK
Ribonuclease kappa

2

0

High-throughput

0.316

High

168099

TMM88
Transmembrane protein 88

2

0

High-throughput

0.316

High

168102

GOT1A
Vesicle transport protein GOT1A

2

0

High-throughput

0.316

High

168103

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.316

High

168105

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

168106

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.316

High

168111

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.316

High

168115

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.316

High

168127

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

168132

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.316

High

168088

CUL3
Cullin-3

2

0

High-throughput

0.305

High

168092

RHG31
Rho GTPase-activating protein 31

2

0

High-throughput

0.298

High

168075

PML
Protein PML

1

0

High-throughput

0.279

Low

168080

ATX3
Ataxin-3

1

0

High-throughput

0.279

Low

168081

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.279

Low

168085

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

0

High-throughput

0.279

Low

168109

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.279

Low

168110

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

168128

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.279

Low

168131

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

0

High-throughput

0.279

Low

168134

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.279

Low

168142

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low

168117

TIRR
Tudor-interacting repair regulator protein

1

0

High-throughput

0.269

Low

168070

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

168141

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

168059

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

168063

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.249

Low

168065

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

168066

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

168068

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

168071

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

168074

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

168076

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

168078

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

168079

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

168082

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.249

Low

168083

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.249

Low

168091

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.249

Low

168095

MIDN
Midnolin

1

0

High-throughput

0.249

Low

168100

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

168101

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

168107

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

168112

FAF2
FAS-associated factor 2

1

0

High-throughput

0.249

Low

168114

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

168120

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

168123

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

168125

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.249

Low

168126

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

168129

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.249

Low

168135

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

168137

L10K
Leydig cell tumor 10 kDa protein homolog

1

0

Small-scale

0.249

Low

168140

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

168077

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

168094

SV2C
Synaptic vesicle glycoprotein 2C

1

0

High-throughput

0.232

Low

168096

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

168104

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.232

Low

168108

S35G2
Solute carrier family 35 member G2

1

0

High-throughput

0.232

Low

168130

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.232

Low

168136

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025