Protein: TF3C1
General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)

Gene: TF3C1, GTF3C1
Organism: Homo sapiens
Interactions: 237
UniProt ID: Q12789

Gene Ontology (top 5):
GO:0000127 - transcription factor TFIIIC complex
GO:0000995 - RNA polymerase III general transcription initiation factor activity
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085805

ZN764
Zinc finger protein 764

4

1

High-throughput

0.793

High

69773

ZN785
Zinc finger protein 785

2

1

High-throughput

0.726

High

1085816

KLF6
Krueppel-like factor 6

1

2

High-throughput

0.698

High

1085850

TF3C4
General transcription factor 3C polypeptide 4

4

1

Small-scale

0.696

High

371881

MYC
Myc proto-oncogene protein

4

2

High-throughput

0.686

High

643807

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

0

High-throughput

0.682

High

1085789

TF3C2
General transcription factor 3C polypeptide 2

5

0

Small-scale

0.676

High

1085863

TF3C3
General transcription factor 3C polypeptide 3

4

0

Small-scale

0.658

High

998253

H31
Histone H3.1

3

2

High-throughput

0.640

High

226009

STX6
Syntaxin-6

3

0

High-throughput

0.638

High

686119

RL13
Large ribosomal subunit protein eL13

3

0

High-throughput

0.622

High

675479

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.618

High

1085860

KLF12
Krueppel-like factor 12

1

2

High-throughput

0.618

High

1085753

TEBP
Prostaglandin E synthase 3

2

0

High-throughput

0.602

High

1085755

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.588

High

334551

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

0

Small-scale

0.586

High

1085781

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.586

High

446953

NPM
Nucleophosmin

2

0

High-throughput

0.585

High

586658

RS2
Small ribosomal subunit protein uS5

2

0

High-throughput

0.585

High

919916

PLK1
Serine/threonine-protein kinase PLK1

2

0

High-throughput

0.585

High

648355

USF1
Upstream stimulatory factor 1

2

2

Small-scale

0.584

High

1085833

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

1

Small-scale

0.584

High

1085837

WDR76
WD repeat-containing protein 76

2

1

High-throughput

0.584

High

1085807

ZN668
Zinc finger protein 668

1

0

High-throughput

0.578

High

760432

SDC2
Syndecan-2

2

2

High-throughput

0.574

High

129019

MEN1
Menin

2

0

High-throughput

0.559

High

766495

PHB1
Prohibitin 1

2

0

Small-scale

0.559

High

972674

RS23
Small ribosomal subunit protein uS12

2

0

High-throughput

0.559

High

979563

H4
Histone H4

2

0

High-throughput

0.559

High

1085822

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.553

High

1085803

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.549

High

338829

CBX6
Chromobox protein homolog 6

1

2

High-throughput

0.536

High

407079

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

854018

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

1014077

CBX1
Chromobox protein homolog 1

1

2

High-throughput

0.536

High

1085739

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.536

High

1085844

FOXJ2
Forkhead box protein J2

1

2

High-throughput

0.536

High

1085852

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.536

High

241522

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.533

High

1085749

NFIX
Nuclear factor 1 X-type

2

1

High-throughput

0.533

High

1085793

ESR2
Estrogen receptor beta

2

0

High-throughput

0.528

High

923383

MK10
Mitogen-activated protein kinase 10

1

0

High-throughput

0.518

High

938340

NH2L1
NHP2-like protein 1

1

0

High-throughput

0.518

High

1085782

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.518

High

1085829

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

216675

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

599197

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.513

High

625341

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

785123

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

833728

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

858901

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

859802

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

958937

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

1085754

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.513

High

1085801

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1085804

AURKB
Aurora kinase B

1

0

High-throughput

0.513

High

1085819

RBM4B
RNA-binding protein 4B

1

0

High-throughput

0.513

High

1085823

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1085832

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

586980

CHIN
N-chimaerin

1

1

High-throughput

0.494

High

609874

IBP3
Insulin-like growth factor-binding protein 3

1

1

High-throughput

0.494

High

650142

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.494

High

258452

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.493

High

1085848

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

548989

KPSH1
Serine/threonine-protein kinase H1

1

1

High-throughput

0.489

High

726656

SDC4
Syndecan-4

1

2

High-throughput

0.489

High

1037912

HEN2
Helix-loop-helix protein 2

1

1

High-throughput

0.489

High

1085811

PNMA5
Paraneoplastic antigen-like protein 5

1

2

High-throughput

0.489

High

1085812

PSKH2
Serine/threonine-protein kinase H2

1

1

High-throughput

0.489

High

1085818

FOXB1
Forkhead box protein B1

1

4

High-throughput

0.489

High

1085824

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.489

High

885753

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.486

High

1085770

RBM23
Probable RNA-binding protein 23

1

1

High-throughput

0.481

High

507885

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

964248

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

190890

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

259861

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

277661

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.479

High

285240

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

406112

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

418958

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

487238

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

540007

BCR
Breakpoint cluster region protein

1

1

High-throughput

0.479

High

591616

H2AX
Histone H2AX

1

2

High-throughput

0.479

High

685174

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.479

High

765448

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

832515

ETV3
ETS translocation variant 3

1

1

High-throughput

0.479

High

862075

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

872260

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

881511

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

883522

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

1016808

H33
Histone H3.3

1

2

High-throughput

0.479

High

1026707

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

High-throughput

0.479

High

1067234

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

1085738

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1085740

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1085747

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1085773

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.479

High

1085776

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.479

High

1085780

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1085794

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1085813

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1085814

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1085826

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

1085828

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1085841

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1085855

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1085856

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

1085756

Q1RN33
Melanoma antigen A 4

1

1

High-throughput

0.470

High

131995

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

194160

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

218122

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

315518

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319714

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

472684

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

541976

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

588559

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

616174

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

620326

NUCL
Nucleolin

1

0

High-throughput

0.458

High

664723

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

695314

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

697090

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

768055

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799865

COIL
Coilin

1

0

High-throughput

0.458

High

830635

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

839251

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

846262

MATR3
Matrin-3

1

0

High-throughput

0.458

High

851535

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

883229

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

886801

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

897252

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

904649

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

925909

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

Small-scale

0.458

High

934530

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

980726

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1085741

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1085742

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1085745

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1085751

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1085769

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1085778

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

1085788

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1085791

DNJC9
DnaJ homolog subfamily C member 9

1

0

High-throughput

0.458

High

1085792

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1085796

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1085797

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1085800

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1085806

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1085810

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1085817

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1085821

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

Small-scale

0.458

High

1085825

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1085835

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1085840

ANLN
Anillin

1

0

High-throughput

0.458

High

1085842

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1085843

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1085845

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1085847

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1085849

MCM8
DNA helicase MCM8

1

0

High-throughput

0.458

High

1085857

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

1085859

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1050404

UBE3A
Ubiquitin-protein ligase E3A

1

1

Small-scale

0.457

High

62496

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.445

High

1085775

S35F3
Solute carrier family 35 member F3

1

1

High-throughput

0.445

High

1085862

TF3C5
General transcription factor 3C polypeptide 5

1

1

Small-scale

0.445

High

848322

MAGA4
Melanoma-associated antigen 4

1

1

High-throughput

0.439

High

1085820

HGH1
Protein HGH1 homolog

1

1

High-throughput

0.439

High

130450

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.438

High

226543

TLX2
T-cell leukemia homeobox protein 2

1

1

High-throughput

0.437

High

411824

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1085752

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.437

High

1085758

BRDT
Bromodomain testis-specific protein

1

3

High-throughput

0.437

High

1085815

FEV
Protein FEV

1

1

High-throughput

0.437

High

1085854

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

290547

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.426

High

337091

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

429791

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

841348

RBM34
RNA-binding protein 34

1

0

High-throughput

0.426

High

1037133

H11
Histone H1.1

1

0

High-throughput

0.426

High

1037469

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.426

High

1057987

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.426

High

1085743

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

1085744

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1085748

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1085762

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1085772

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1085786

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

1085795

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.426

High

1085827

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

1085838

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1085851

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

1085761

Q6IA98
RNPC4 protein

1

1

High-throughput

0.417

High

1085802

Q96BK8
Protein HGH1 homolog

1

1

High-throughput

0.417

High

616749

SDC1
Syndecan-1

1

2

High-throughput

0.407

High

1085777

LAT4
Large neutral amino acids transporter small subunit 4

1

1

High-throughput

0.407

High

1085783

S43A3
Equilibrative nucleobase transporter 1

1

1

High-throughput

0.407

High

591286

CD44
CD44 antigen

3

0

High-throughput

0.345

High

1085785

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

169245

CASQ2
Calsequestrin-2

2

0

High-throughput

0.318

High

1085861

NGN3
Neurogenin-3

2

0

Small-scale

0.318

High

1085764

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

599107

CBPE
Carboxypeptidase E

1

0

High-throughput

0.282

High

1085836

AKTIP
AKT-interacting protein

1

0

High-throughput

0.282

High

1085839

TBC17
TBC1 domain family member 17

1

0

High-throughput

0.282

High

849152

KSYK
Tyrosine-protein kinase SYK

1

0

High-throughput

0.279

Low

922377

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.279

Low

1085746

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1085759

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

1085774

CUL9
Cullin-9

1

0

High-throughput

0.279

Low

1085787

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1085790

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.279

Low

1085798

CPNE4
Copine-4

1

0

High-throughput

0.279

Low

1085799

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.279

Low

1085808

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.279

Low

1085831

TXNIP
Thioredoxin-interacting protein

1

0

High-throughput

0.279

Low

1085853

INTU
Protein inturned

1

0

High-throughput

0.279

Low

1085858

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

1085864

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

272121

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

318744

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

472304

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

1085750

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1085757

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1085760

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1085763

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1085765

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1085766

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

1085767

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.249

Low

1085768

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1085779

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1085784

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1085809

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1085830

DUS15
Dual specificity protein phosphatase 15

1

0

High-throughput

0.249

Low

1085834

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1085846

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.249

Low

912665

CTR2
Cationic amino acid transporter 2

1

0

High-throughput

0.232

Low

1085771

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025