Protein: IBTK
Inhibitor of Bruton tyrosine kinase (IBtk)

Gene: IBTK
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9P2D0

Gene Ontology (top 5):
GO:0001933 - negative regulation of protein phosphorylation
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016020 - membrane
GO:0019901 - protein kinase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042716

CUL3
Cullin-3

10

20

Small-scale

0.972

High

892922

IF4A1
Eukaryotic initiation factor 4A-I

5

7

High-throughput

0.932

High

986402

BTK
Tyrosine-protein kinase BTK

3

8

Small-scale

0.870

High

836048

GSK3B
Glycogen synthase kinase-3 beta

2

9

Small-scale

0.754

High

408693

KPCB
Protein kinase C beta type

1

7

Small-scale

0.724

High

616563

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.691

High

1184073

DHX30
ATP-dependent RNA helicase DHX30

1

3

High-throughput

0.691

High

1344145

DDX21
Nucleolar RNA helicase 2

1

7

High-throughput

0.691

High

1051926

IF4A2
Eukaryotic initiation factor 4A-II

2

8

High-throughput

0.675

High

275666

POP7
Ribonuclease P protein subunit p20

3

1

High-throughput

0.656

High

1068514

KPCD1
Serine/threonine-protein kinase D1

1

8

Small-scale

0.648

High

134233

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

High-throughput

0.618

High

375012

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

566495

KPCA
Protein kinase C alpha type

1

8

Small-scale

0.618

High

581068

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.618

High

682047

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.618

High

708376

TTK
Dual specificity protein kinase TTK

1

10

High-throughput

0.618

High

835548

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.618

High

969117

KPCE
Protein kinase C epsilon type

1

7

Small-scale

0.618

High

984546

KPCD
Protein kinase C delta type

1

7

Small-scale

0.618

High

1071710

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.618

High

1147670

FTM
Protein fantom

1

9

High-throughput

0.618

High

1167331

BCOR
BCL-6 corepressor

1

15

High-throughput

0.618

High

1350231

IBTK
Inhibitor of Bruton tyrosine kinase

1

18

Small-scale

0.618

High

323240

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

6

High-throughput

0.584

High

1120024

PDCD4
Programmed cell death protein 4

1

1

Small-scale

0.561

High

397185

KPCG
Protein kinase C gamma type

1

10

Small-scale

0.553

High

996574

ITK
Tyrosine-protein kinase ITK/TSK

1

8

Small-scale

0.553

High

1206078

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.553

High

1296311

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

8

High-throughput

0.553

High

1350234

HECD1
E3 ubiquitin-protein ligase HECTD1

1

13

High-throughput

0.553

High

401158

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

722050

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.536

High

722306

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.536

High

778046

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.536

High

807038

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.536

High

907574

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

1058311

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

High-throughput

0.536

High

1069545

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

1164156

WDR74
WD repeat-containing protein 74

1

11

High-throughput

0.536

High

1327371

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.536

High

328982

TOP3B
DNA topoisomerase 3-beta-1

2

2

High-throughput

0.533

High

1219254

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

14

High-throughput

0.533

High

782059

RGS2
Regulator of G-protein signaling 2

1

2

High-throughput

0.515

High

133716

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

400406

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.513

High

788933

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.513

High

973270

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.513

High

1056821

ESPL1
Separin

1

0

High-throughput

0.513

High

1102186

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

906175

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.508

High

283615

SRP72
Signal recognition particle subunit SRP72

1

2

High-throughput

0.489

High

949184

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.489

High

61487

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

High-throughput

0.479

High

398123

ISG15
Ubiquitin-like protein ISG15

1

20

High-throughput

0.479

High

476494

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.479

High

553938

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

607179

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

6

Small-scale

0.479

High

649797

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

652478

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

721657

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

844269

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.479

High

897320

CSN2
COP9 signalosome complex subunit 2

1

5

Small-scale

0.479

High

921452

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.479

High

928036

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

High-throughput

0.479

High

967992

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

1030528

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.479

High

1035030

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.479

High

1051496

DCTN1
Dynactin subunit 1

1

4

High-throughput

0.479

High

1054006

CAPR1
Caprin-1

1

3

High-throughput

0.479

High

1063657

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1066807

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1068960

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

1080419

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

1139456

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

High-throughput

0.479

High

1148060

MSL1
Male-specific lethal 1 homolog

1

1

High-throughput

0.479

High

1183782

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.479

High

1187834

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

High-throughput

0.479

High

1192397

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.479

High

1200712

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1202161

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

Small-scale

0.479

High

1238081

CE120
Centrosomal protein of 120 kDa

1

8

High-throughput

0.479

High

1240474

POC1A
POC1 centriolar protein homolog A

1

12

High-throughput

0.479

High

1241047

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1254292

BICD2
Protein bicaudal D homolog 2

1

8

High-throughput

0.479

High

1256447

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1260938

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1261435

NUDC2
NudC domain-containing protein 2

1

16

High-throughput

0.479

High

1268186

LAR4B
La-related protein 4B

1

2

High-throughput

0.479

High

1269809

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1281793

IGSF8
Immunoglobulin superfamily member 8

1

6

High-throughput

0.479

High

1311554

PCGF1
Polycomb group RING finger protein 1

1

9

High-throughput

0.479

High

1311909

CSN4
COP9 signalosome complex subunit 4

1

1

Small-scale

0.479

High

1332712

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1333004

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

1334429

NANOG
Homeobox protein NANOG

1

5

High-throughput

0.479

High

1335846

CENPJ
Centromere protein J

1

2

High-throughput

0.479

High

1347403

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.479

High

1350232

TRM7
tRNA

1

2

High-throughput

0.479

High

1350235

CSN3
COP9 signalosome complex subunit 3

1

6

Small-scale

0.479

High

1350236

CP131
Centrosomal protein of 131 kDa

1

3

High-throughput

0.479

High

1350237

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.479

High

313361

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

887974

CD81
CD81 antigen

1

0

High-throughput

0.458

High

893184

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

928703

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

1200068

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.458

High

1308506

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

1319331

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

111426

J3QQY0
MSL complex subunit 1

1

1

High-throughput

0.445

High

1124641

ODFP2
Outer dense fiber protein 2

1

2

High-throughput

0.437

High

1145964

CP135
Centrosomal protein of 135 kDa

1

4

High-throughput

0.437

High

1172777

CE128
Centrosomal protein of 128 kDa

1

4

High-throughput

0.437

High

1335990

MOV10
Helicase MOV-10

1

4

High-throughput

0.437

High

87586

C9JYM0
POP7 homolog, ribonuclease P/MRP subunit

1

1

High-throughput

0.407

High

1234794

RP25L
Ribonuclease P protein subunit p25-like protein

3

0

High-throughput

0.347

High

1350233

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.251

Low

304889

MFN2
Mitofusin-2

1

0

High-throughput

0.249

Low

940659

F193A
Protein FAM193A

1

0

High-throughput

0.249

Low

1137803

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.249

Low

1297927

CBPC4
Cytosolic carboxypeptidase 4

1

0

High-throughput

0.249

Low

1347616

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024