Protein: BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)

Gene: BIG1, ARFGEF1
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q9Y6D6

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1378202

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

5

9

Small-scale

0.924

High

1303447

MYCBP
c-Myc-binding protein

3

1

Small-scale

0.683

High

1255554

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

3

1

High-throughput

0.667

High

1357948

LAMP3
Lysosome-associated membrane glycoprotein 3

3

7

High-throughput

0.667

High

1190625

KI21A
Kinesin-like protein KIF21A

2

2

Small-scale

0.621

High

1318634

DPY30
Protein dpy-30 homolog

2

1

Small-scale

0.619

High

776216

ARL1
ADP-ribosylation factor-like protein 1

1

20

High-throughput

0.618

High

913219

ARF6
ADP-ribosylation factor 6

1

16

High-throughput

0.618

High

498387

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

3

Small-scale

0.594

High

582583

NUCL
Nucleolin

2

0

Small-scale

0.585

High

740288

NUP62
Nuclear pore glycoprotein p62

2

0

Small-scale

0.585

High

914499

RB11A
Ras-related protein Rab-11A

2

7

High-throughput

0.584

High

623020

EDNRB
Endothelin receptor type B

2

7

High-throughput

0.574

High

824740

NPY2R
Neuropeptide Y receptor type 2

2

5

High-throughput

0.574

High

1237342

SIGL1
SIGLEC family-like protein 1

2

3

High-throughput

0.574

High

1057153

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

8

Small-scale

0.569

High

1030778

SLAF1
Signaling lymphocytic activation molecule

2

8

High-throughput

0.558

High

1331765

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.553

High

717471

CTNB1
Catenin beta-1

1

3

Small-scale

0.552

High

354626

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

6

High-throughput

0.552

High

1035159

MYO9B
Unconventional myosin-IXb

1

2

Small-scale

0.536

High

207679

AKA10
A-kinase anchor protein 10, mitochondrial

1

2

High-throughput

0.536

High

257123

DJC13
DnaJ homolog subfamily C member 13

1

5

High-throughput

0.536

High

403382

LA
Lupus La protein

1

1

Small-scale

0.536

High

726496

BASI
Basigin

1

8

High-throughput

0.536

High

794345

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.536

High

814320

GLR
Glucagon receptor

1

2

High-throughput

0.536

High

855586

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.536

High

1232107

LRC25
Leucine-rich repeat-containing protein 25

1

2

High-throughput

0.536

High

1299286

OPALI
Opalin

1

2

High-throughput

0.536

High

1349824

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

6

High-throughput

0.536

High

1377938

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

1377956

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.536

High

409291

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.515

High

962495

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.515

High

603825

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.513

High

1161460

BORA
Protein aurora borealis

1

0

High-throughput

0.513

High

1203156

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

1224676

AGRG2
Adhesion G-protein coupled receptor G2

1

0

High-throughput

0.513

High

645870

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

1

Small-scale

0.504

High

1053742

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

3

Small-scale

0.500

High

1240130

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.493

High

131988

UPK2
Uroplakin-2

1

3

High-throughput

0.489

High

172310

GP182
G-protein coupled receptor 182

1

16

High-throughput

0.489

High

595580

GRAH
Granzyme H

1

3

High-throughput

0.489

High

599036

FPR1
fMet-Leu-Phe receptor

1

10

High-throughput

0.489

High

639672

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

High-throughput

0.489

High

656392

DMB
HLA class II histocompatibility antigen, DM beta chain

1

6

High-throughput

0.489

High

864339

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

2

High-throughput

0.489

High

957967

EFNB1
Ephrin-B1

1

2

High-throughput

0.489

High

971845

HEN2
Helix-loop-helix protein 2

1

3

High-throughput

0.489

High

1020155

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

7

High-throughput

0.489

High

1031127

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

16

High-throughput

0.489

High

1059524

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.489

High

1082781

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.489

High

1083623

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.489

High

1198029

CLC14
C-type lectin domain family 14 member A

1

1

High-throughput

0.489

High

1202767

P2RY8
P2Y purinoceptor 8

1

20

High-throughput

0.489

High

1233083

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

3

High-throughput

0.489

High

1254699

HUMMR
Protein MGARP

1

3

High-throughput

0.489

High

1287791

ORAI1
Calcium release-activated calcium channel protein 1

1

1

High-throughput

0.489

High

1328372

F234A
Protein FAM234A

1

2

High-throughput

0.489

High

1343113

TMM9B
Transmembrane protein 9B

1

6

High-throughput

0.489

High

1344939

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

2

High-throughput

0.489

High

1355547

CLC2D
C-type lectin domain family 2 member D

1

5

High-throughput

0.489

High

1357812

KCNH4
Potassium voltage-gated channel subfamily H member 4

1

3

High-throughput

0.489

High

1377079

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

5

High-throughput

0.489

High

1378147

GPR45
Probable G-protein coupled receptor 45

1

5

High-throughput

0.489

High

1378171

NPTN
Neuroplastin

1

10

High-throughput

0.489

High

132649

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.479

High

169685

BET1
BET1 homolog

1

6

High-throughput

0.479

High

206239

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

213084

STX6
Syntaxin-6

1

6

High-throughput

0.479

High

339207

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

349771

RASH
GTPase HRas

1

11

High-throughput

0.479

High

527919

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

554186

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

567353

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

592090

RAB4A
Ras-related protein Rab-4A

1

16

High-throughput

0.479

High

721914

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

738154

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

750000

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

845394

RAB7A
Ras-related protein Rab-7a

1

19

High-throughput

0.479

High

845835

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

895339

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.479

High

1152235

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1163934

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1350600

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

505026

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

578374

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

849011

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

1035651

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1218663

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1239786

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1344878

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

1131044

SNP47
Synaptosomal-associated protein 47

1

0

Small-scale

0.438

High

199983

SPIT2
Kunitz-type protease inhibitor 2

1

2

High-throughput

0.437

High

260648

TP4A3
Protein tyrosine phosphatase type IVA 3

1

4

High-throughput

0.437

High

385813

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

484401

SCHI1
Schwannomin-interacting protein 1

1

1

High-throughput

0.437

High

1166120

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1172481

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1230448

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1259948

TB22A
TBC1 domain family member 22A

1

2

High-throughput

0.437

High

1318482

CD244
Natural killer cell receptor 2B4

1

6

High-throughput

0.437

High

1329342

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1348631

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.437

High

1345853

TB22B
TBC1 domain family member 22B

1

2

Small-scale

0.407

High

329063

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

1150419

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

957513

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1089290

TATD3
Putative deoxyribonuclease TATDN3

1

0

High-throughput

0.279

Low

1318994

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

354012

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024