Protein: S4A5
Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5)

Gene: S4A5, SLC4A5
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q9BY07

Gene Ontology (top 5):
GO:0002064 - epithelial cell development
GO:0003014 - renal system process
GO:0003073 - regulation of systemic arterial blood pressure
GO:0005452 - solute:inorganic anion antiporter activity
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1417610

CADM1
Cell adhesion molecule 1

1

1

High-throughput

0.575

High

1417611

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1371657

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.457

High

48773

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

253687

IMA7
Importin subunit alpha-7

1

1

High-throughput

0.445

High

401429

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

691391

1433T
14-3-3 protein theta

1

13

High-throughput

0.445

High

692126

MARK3
MAP/microtubule affinity-regulating kinase 3

1

5

High-throughput

0.445

High

730208

1433B
14-3-3 protein beta/alpha

1

13

High-throughput

0.445

High

790178

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

2

High-throughput

0.445

High

921769

COPB
Coatomer subunit beta

1

1

High-throughput

0.445

High

966833

1433G
14-3-3 protein gamma

1

13

High-throughput

0.445

High

971955

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.445

High

1010524

EREP3
Protein ENTREP3

1

1

High-throughput

0.445

High

1049735

1433F
14-3-3 protein eta

1

13

High-throughput

0.445

High

1186431

ASTRB
Protein Aster-B

1

2

High-throughput

0.445

High

1216311

MTCL3
Microtubule cross-linking factor 3

1

1

High-throughput

0.445

High

1270514

MARK2
Serine/threonine-protein kinase MARK2

1

5

High-throughput

0.445

High

1287432

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

6

High-throughput

0.445

High

1293289

LSR
Lipolysis-stimulated lipoprotein receptor

1

1

High-throughput

0.445

High

1312243

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.445

High

1386193

ASTRA
Protein Aster-A

1

2

High-throughput

0.445

High

1390709

DYL2
Dynein light chain 2, cytoplasmic

1

2

High-throughput

0.445

High

1393074

CREL1
Protein disulfide isomerase CRELD1

1

5

High-throughput

0.445

High

1417620

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

1

High-throughput

0.445

High

1417622

MARK1
Serine/threonine-protein kinase MARK1

1

6

High-throughput

0.445

High

1417625

TM59L
Transmembrane protein 59-like

1

1

High-throughput

0.445

High

1417627

PRP19
Pre-mRNA-processing factor 19

1

1

High-throughput

0.445

High

1417628

CBPC1
Cytosolic carboxypeptidase 1

1

1

High-throughput

0.445

High

128310

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.426

High

134141

IPO5
Importin-5

1

0

High-throughput

0.426

High

246313

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.426

High

562641

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.426

High

606033

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.426

High

608180

PYRG1
CTP synthase 1

1

0

High-throughput

0.426

High

813207

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.426

High

878705

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

0

High-throughput

0.426

High

900491

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.426

High

906595

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.426

High

959243

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.426

High

1165540

LY6K
Lymphocyte antigen 6K

1

0

High-throughput

0.426

High

1211342

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

0

High-throughput

0.426

High

1247741

PLPR3
Phospholipid phosphatase-related protein type 3

1

0

High-throughput

0.426

High

1290219

GP180
Integral membrane protein GPR180

1

0

High-throughput

0.426

High

1350770

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

0

High-throughput

0.426

High

1380527

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.426

High

1381340

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.426

High

1417612

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.426

High

1417615

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.426

High

1417626

AGO2
Protein argonaute-2

1

0

High-throughput

0.426

High

1417630

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.426

High

1417631

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.426

High

132509

CDC7
Cell division cycle 7-related protein kinase

1

2

High-throughput

0.407

High

165407

PSA7
Proteasome subunit alpha type-7

1

3

High-throughput

0.407

High

1126360

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.407

High

207873

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.407

High

282625

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.407

High

611324

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.407

High

681009

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.407

High

886578

CTCF
Transcriptional repressor CTCF

1

1

High-throughput

0.407

High

913901

ZN143
Zinc finger protein 143

1

1

High-throughput

0.407

High

954895

PSA6
Proteasome subunit alpha type-6

1

3

High-throughput

0.407

High

990686

1433Z
14-3-3 protein zeta/delta

1

13

High-throughput

0.407

High

1094806

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.407

High

1105552

OS9
Protein OS-9

1

3

High-throughput

0.407

High

1153665

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

1

High-throughput

0.407

High

1188015

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

1

High-throughput

0.407

High

1212611

HECD3
E3 ubiquitin-protein ligase HECTD3

1

5

High-throughput

0.407

High

1272055

ZN771
Zinc finger protein 771

1

2

High-throughput

0.407

High

1290294

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

2

High-throughput

0.407

High

1311166

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.407

High

1330223

ZN655
Zinc finger protein 655

1

1

High-throughput

0.407

High

1337000

DIK2A
Divergent protein kinase domain 2A

1

2

High-throughput

0.407

High

1388088

ERLEC
Endoplasmic reticulum lectin 1

1

3

High-throughput

0.407

High

1389750

C1GLC
C1GALT1-specific chaperone 1

1

3

High-throughput

0.407

High

1417616

FBX6
F-box only protein 6

1

1

High-throughput

0.407

High

1417618

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

1

High-throughput

0.407

High

1417623

FA8A1
Protein FAM8A1

1

1

High-throughput

0.407

High

1417624

SE1L1
Protein sel-1 homolog 1

1

1

High-throughput

0.407

High

1417629

DJC16
DnaJ homolog subfamily C member 16

1

2

High-throughput

0.407

High

1417632

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

1

High-throughput

0.407

High

482165

RET1
Retinol-binding protein 1

1

0

High-throughput

0.269

Low

1099770

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.249

Low

61616

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.232

Low

214618

WDR62
WD repeat-containing protein 62

1

0

High-throughput

0.232

Low

290715

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.232

Low

299576

TRIO
Triple functional domain protein

1

0

High-throughput

0.232

Low

423936

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

469331

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.232

Low

571511

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.232

Low

895645

SERPH
Serpin H1

1

0

High-throughput

0.232

Low

999554

NOMO3
BOS complex subunit NOMO3

1

0

High-throughput

0.232

Low

1038935

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

0

High-throughput

0.232

Low

1110046

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.232

Low

1130431

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low

1136587

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.232

Low

1179211

SGSM1
Small G protein signaling modulator 1

1

0

High-throughput

0.232

Low

1198753

MPPE1
Metallophosphoesterase 1

1

0

High-throughput

0.232

Low

1210391

TT39A
Tetratricopeptide repeat protein 39A

1

0

High-throughput

0.232

Low

1212368

GPTC4
G patch domain-containing protein 4

1

0

High-throughput

0.232

Low

1215360

DCAF8
DDB1- and CUL4-associated factor 8

1

0

High-throughput

0.232

Low

1245614

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.232

Low

1252602

DEFI8
Differentially expressed in FDCP 8 homolog

1

0

High-throughput

0.232

Low

1270331

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.232

Low

1281527

CENPV
Centromere protein V

1

0

High-throughput

0.232

Low

1332761

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.232

Low

1347579

ZN420
Zinc finger protein 420

1

0

High-throughput

0.232

Low

1385195

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.232

Low

1386355

FAF2
FAS-associated factor 2

1

0

High-throughput

0.232

Low

1392456

TECT2
Tectonic-2

1

0

High-throughput

0.232

Low

1393576

INT4
Integrator complex subunit 4

1

0

High-throughput

0.232

Low

1394404

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.232

Low

1415305

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.232

Low

1417609

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.232

Low

1417613

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.232

Low

1417614

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.232

Low

1417617

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.232

Low

1417619

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.232

Low

1417621

DTL
Denticleless protein homolog

1

0

High-throughput

0.232

Low

1417633

PXMP4
Peroxisomal membrane protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025