Protein: MPPE1
Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5)

Gene: MPPE1
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q53F39

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005794 - Golgi apparatus
GO:0006506 - GPI anchor biosynthetic process
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0030145 - manganese ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1198730

BT2A2
Butyrophilin subfamily 2 member A2

2

0

High-throughput

0.679

High

1198748

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

2

0

High-throughput

0.679

High

1198754

LRRC3
Leucine-rich repeat-containing protein 3

2

0

High-throughput

0.679

High

230798

EXTL3
Exostosin-like 3

2

2

High-throughput

0.628

High

1157359

EXT1
Exostosin-1

2

2

High-throughput

0.628

High

1198722

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

2

3

High-throughput

0.628

High

1198726

GALT4
Polypeptide N-acetylgalactosaminyltransferase 4

2

3

High-throughput

0.628

High

1198733

PIGB
GPI alpha-1,2-mannosyltransferase 3

2

2

High-throughput

0.628

High

1198738

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

2

1

High-throughput

0.628

High

1198767

POMT2
Protein O-mannosyl-transferase 2

2

1

High-throughput

0.628

High

1198719

AMGO1
Amphoterin-induced protein 1

1

1

High-throughput

0.618

High

161042

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

2

0

High-throughput

0.602

High

1198713

TM214
Transmembrane protein 214

2

0

High-throughput

0.602

High

1198723

TM192
Transmembrane protein 192

2

0

High-throughput

0.602

High

1198725

LARG2
Xylosyl- and glucuronyltransferase LARGE2

2

0

High-throughput

0.602

High

1198729

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

1198745

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.602

High

1198747

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

2

0

High-throughput

0.602

High

1198755

FUT8
Alpha-(1,6)-fucosyltransferase

2

0

High-throughput

0.602

High

1198758

FKRP
Ribitol 5-phosphate transferase FKRP

2

0

High-throughput

0.602

High

1198764

B4GT7
Beta-1,4-galactosyltransferase 7

2

0

High-throughput

0.602

High

1198770

BACE2
Beta-secretase 2

2

0

High-throughput

0.602

High

269676

PLXA2
Plexin-A2

2

1

High-throughput

0.574

High

283692

GPC4
Glypican-4

2

1

High-throughput

0.574

High

320986

SUN1
SUN domain-containing protein 1

2

1

High-throughput

0.574

High

1164335

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

2

1

High-throughput

0.574

High

1187813

UD3A2
UDP-glucuronosyltransferase 3A2

2

1

High-throughput

0.574

High

1198727

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

1

High-throughput

0.574

High

1198752

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

2

2

High-throughput

0.574

High

1198757

ALG9
Alpha-1,2-mannosyltransferase ALG9

2

2

High-throughput

0.574

High

1198765

SUN2
SUN domain-containing protein 2

2

1

High-throughput

0.574

High

1198768

CCPG1
Cell cycle progression protein 1

2

1

High-throughput

0.574

High

1198771

POMT1
Protein O-mannosyl-transferase 1

2

1

High-throughput

0.574

High

1083107

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

3

High-throughput

0.536

High

1198718

GALT7
N-acetylgalactosaminyltransferase 7

1

3

High-throughput

0.536

High

1198735

EXT2
Exostosin-2

1

2

High-throughput

0.536

High

60722

F234B
Protein FAM234B

1

0

High-throughput

0.513

High

1198741

P121A
Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.513

High

1198762

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

0

High-throughput

0.513

High

175376

PLXB2
Plexin-B2

1

2

High-throughput

0.489

High

1198763

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.489

High

1198711

Q53SE7
Germ cell-less homolog 1

1

1

High-throughput

0.470

High

1198742

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.439

High

1198731

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

1198732

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.426

High

380551

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

1

High-throughput

0.407

High

341317

ECEL1
Endothelin-converting enzyme-like 1

2

0

High-throughput

0.328

High

698726

CALX
Calnexin

2

0

High-throughput

0.328

High

1010474

EREP3
Protein ENTREP3

2

0

High-throughput

0.328

High

1125848

FZD2
Frizzled-2

2

0

High-throughput

0.328

High

1126019

GAS6
Growth arrest-specific protein 6

2

0

High-throughput

0.328

High

1132157

ICAM4
Intercellular adhesion molecule 4

2

0

High-throughput

0.328

High

1198712

DIK1A
Divergent protein kinase domain 1A

2

0

High-throughput

0.328

High

1198714

SUSD1
Sushi domain-containing protein 1

2

0

High-throughput

0.328

High

1198716

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

0

High-throughput

0.328

High

1198720

DYR2
Dihydrofolate reductase 2, mitochondrial

2

0

High-throughput

0.328

High

1198721

GLBL2
Beta-galactosidase-1-like protein 2

2

0

High-throughput

0.328

High

1198728

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

1198734

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

2

0

High-throughput

0.328

High

1198736

HMR1
Major histocompatibility complex class I-related protein 1

2

0

High-throughput

0.328

High

1198737

NXPE3
NXPE family member 3

2

0

High-throughput

0.328

High

1198739

TM186
Transmembrane protein 186

2

0

High-throughput

0.328

High

1198746

ABCA3
Phospholipid-transporting ATPase ABCA3

2

0

High-throughput

0.328

High

1198749

LMF2
Lipase maturation factor 2

2

0

High-throughput

0.328

High

1198750

HTAI2
Protein HTATIP2

2

0

High-throughput

0.328

High

1198756

SEM6A
Semaphorin-6A

2

0

High-throughput

0.328

High

1198759

CHSTC
Carbohydrate sulfotransferase 12

2

0

High-throughput

0.328

High

1198760

GINM1
Glycoprotein integral membrane protein 1

2

0

High-throughput

0.328

High

1198761

TM39A
Transmembrane protein 39A

2

0

High-throughput

0.328

High

1198766

TM59L
Transmembrane protein 59-like

2

0

High-throughput

0.328

High

1198769

LRP12
Low-density lipoprotein receptor-related protein 12

2

0

High-throughput

0.328

High

1198751

ZN426
Zinc finger protein 426

1

0

High-throughput

0.299

High

535144

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.279

Low

934212

BI1
Bax inhibitor 1

1

0

High-throughput

0.279

Low

1089104

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.279

Low

1175802

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

1198715

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.279

Low

1198717

FRMD5
FERM domain-containing protein 5

1

0

High-throughput

0.279

Low

1198724

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

1

0

High-throughput

0.279

Low

1198743

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.279

Low

1198740

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.249

Low

1198744

CNT3B
Contactin-associated protein-like 3B

1

0

High-throughput

0.232

Low

1198753

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025