Protein: SH22A
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)

Gene: SH22A, SH2D2A
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q9NP31

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0017124 - SH3 domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440224

LCK
Tyrosine-protein kinase Lck

3

19

Small-scale

0.848

High

699864

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

High-throughput

0.819

High

1051062

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.819

High

1364881

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.819

High

1445803

ASB3
Ankyrin repeat and SOCS box protein 3

2

10

High-throughput

0.819

High

363894

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.778

High

411068

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

155968

SOCS3
Suppressor of cytokine signaling 3

2

20

High-throughput

0.767

High

827931

STAT3
Signal transducer and activator of transcription 3

2

16

High-throughput

0.767

High

855764

CRK
Adapter molecule crk

2

19

High-throughput

0.767

High

849251

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.740

High

472132

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532104

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1445802

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

14

High-throughput

0.692

High

557481

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.681

High

778104

VGFR2
Vascular endothelial growth factor receptor 2

1

20

Small-scale

0.681

High

1435583

PEAK1
Inactive tyrosine-protein kinase PEAK1

3

20

High-throughput

0.667

High

641683

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

1145785

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1381901

TET5B
Terminal nucleotidyltransferase 5B

2

2

High-throughput

0.634

High

1394303

TET5A
Terminal nucleotidyltransferase 5A

2

2

High-throughput

0.634

High

1133177

LASP1
LIM and SH3 domain protein 1

2

20

High-throughput

0.628

High

1333172

KDM1B
Lysine-specific histone demethylase 2

3

3

High-throughput

0.609

High

1445799

PKHB1
Pleckstrin homology domain-containing family B member 1

2

0

High-throughput

0.607

High

540278

SPTB1
Spectrin beta chain, erythrocytic

2

20

High-throughput

0.594

High

1181280

LRRF1
Leucine-rich repeat flightless-interacting protein 1

2

1

High-throughput

0.594

High

1348520

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.594

High

1364997

TSC1
Hamartin

2

20

High-throughput

0.594

High

1433681

ZHX3
Zinc fingers and homeoboxes protein 3

2

4

High-throughput

0.594

High

1445800

DP13A
DCC-interacting protein 13-alpha

2

20

High-throughput

0.594

High

935162

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.586

High

1218141

DC121
DDB1- and CUL4-associated factor 12-like protein 1

2

1

High-throughput

0.579

High

1236181

NAA16
N-alpha-acetyltransferase 16, NatA auxiliary subunit

2

7

High-throughput

0.576

High

1153922

SMAD2
Mothers against decapentaplegic homolog 2

1

6

Small-scale

0.573

High

1014629

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.561

High

1445801

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

16

Small-scale

0.552

High

1333249

ZSCA1
Zinc finger and SCAN domain-containing protein 1

2

9

High-throughput

0.542

High

1097166

MK07
Mitogen-activated protein kinase 7

1

9

High-throughput

0.541

High

520389

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

920508

DAPK1
Death-associated protein kinase 1

1

18

High-throughput

0.536

High

1106512

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

1044710

ARI5A
AT-rich interactive domain-containing protein 5A

2

1

High-throughput

0.526

High

1445804

RA54B
DNA repair and recombination protein RAD54B

1

9

High-throughput

0.504

High

1182866

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

7

High-throughput

0.501

High

1220827

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.479

High

1116033

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

18

High-throughput

0.445

High

1351534

HAVR2
Hepatitis A virus cellular receptor 2

1

7

Small-scale

0.442

High

1251843

PPR21
Protein phosphatase 1 regulatory subunit 21

2

0

High-throughput

0.310

High

1293449

CQ082
Putative uncharacterized protein LINC02875

2

0

High-throughput

0.300

High

907696

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.279

Low

326193

FSBP
Fibrinogen silencer-binding protein

1

0

High-throughput

0.272

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025