Protein: K2C80
Keratin, type II cytoskeletal 80 (Cytokeratin-80) (CK-80) (Keratin-80) (K80) (Type-II keratin Kb20)

Gene: K2C80, KRT80
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q6KB66

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0030280 - structural constituent of skin epidermis
GO:0031424 - keratinization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618048

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.871

High

777400

K1C20
Keratin, type I cytoskeletal 20

3

20

High-throughput

0.871

High

475603

K1C19
Keratin, type I cytoskeletal 19

2

20

High-throughput

0.794

High

1127790

K1H2
Keratin, type I cuticular Ha2

2

20

High-throughput

0.794

High

300386

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

300581

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

300774

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.783

High

385127

K1C14
Keratin, type I cytoskeletal 14

2

20

High-throughput

0.783

High

476339

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

1127651

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

1145987

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.783

High

1178737

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

1235611

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

1235616

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

1235612

K1C25
Keratin, type I cytoskeletal 25

1

20

High-throughput

0.621

High

563916

CFTR
Cystic fibrosis transmembrane conductance regulator

2

15

High-throughput

0.611

High

1235632

AIRIM
AFG2-interacting ribosome maturation factor

2

2

High-throughput

0.606

High

1235635

CSN3
COP9 signalosome complex subunit 3

2

0

High-throughput

0.580

High

893939

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.573

High

337221

LCA5L
Lebercilin-like protein

2

2

High-throughput

0.553

High

681840

RBTN2
Rhombotin-2

2

7

High-throughput

0.553

High

1090718

TRAF2
TNF receptor-associated factor 2

1

13

High-throughput

0.536

High

1235618

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

1235619

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.536

High

643367

OSBP1
Oxysterol-binding protein 1

1

0

High-throughput

0.513

High

1235615

STYX
Serine/threonine/tyrosine-interacting protein

1

0

Small-scale

0.513

High

1235636

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

7

Small-scale

0.501

High

1235626

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

10

High-throughput

0.489

High

1235629

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.489

High

1235631

IFT57
Intraflagellar transport protein 57 homolog

1

1

High-throughput

0.489

High

1235633

RRBP1
Ribosome-binding protein 1

1

2

High-throughput

0.489

High

141530

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

Small-scale

0.479

High

227590

SPOP
Speckle-type POZ protein

1

8

High-throughput

0.479

High

247962

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

293848

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.479

High

302554

RNF8
E3 ubiquitin-protein ligase RNF8

1

10

High-throughput

0.479

High

324927

HEXI1
Protein HEXIM1

1

17

High-throughput

0.479

High

342916

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

414028

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

485212

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

537348

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

664767

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.479

High

1045405

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1088399

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

17

High-throughput

0.479

High

1118062

DX39B
Spliceosome RNA helicase DDX39B

1

15

High-throughput

0.479

High

1132761

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

17

High-throughput

0.479

High

1235609

RICTR
Rapamycin-insensitive companion of mTOR

1

4

High-throughput

0.479

High

1235613

ARMC8
Armadillo repeat-containing protein 8

1

2

High-throughput

0.479

High

1235617

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.479

High

1235620

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

5

Small-scale

0.479

High

1235624

DDX24
ATP-dependent RNA helicase DDX24

1

16

High-throughput

0.479

High

1235625

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1235627

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

8

High-throughput

0.479

High

1235628

ANLN
Anillin

1

9

High-throughput

0.479

High

1235634

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

487432

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

284583

ECI2
Enoyl-CoA delta isomerase 2

1

3

High-throughput

0.445

High

765624

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

952208

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

1209270

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

297636

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.437

High

1235610

MEPCE
7SK snRNA methylphosphate capping enzyme

1

8

High-throughput

0.437

High

1235621

CIC
Protein capicua homolog

1

5

High-throughput

0.437

High

1235623

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.437

High

1063789

LG3BP
Galectin-3-binding protein

1

6

High-throughput

0.407

High

1235614

SULF2
Extracellular sulfatase Sulf-2

1

8

High-throughput

0.407

High

1235622

PSF3
DNA replication complex GINS protein PSF3

2

0

High-throughput

0.316

High

423969

CP17A
Steroid 17-alpha-hydroxylase/17,20 lyase

1

0

High-throughput

0.279

Low

1235630

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low

1219481

RNLS
Renalase

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025