Protein: CCN1
CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)

Gene: CCN1
Organism: Homo sapiens
Interactions: 44
UniProt ID: O00622

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0002041 - intussusceptive angiogenesis
GO:0003181 - atrioventricular valve morphogenesis
GO:0003278 - apoptotic process involved in heart morphogenesis
GO:0003281 - ventricular septum development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

142040

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

142044

APOD
Apolipoprotein D

2

0

High-throughput

0.602

High

142062

NOTC2
Neurogenic locus notch homolog protein 2

2

4

High-throughput

0.601

High

142057

CDC42
Cell division control protein 42 homolog

2

4

High-throughput

0.595

High

142053

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.536

High

142075

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

1

High-throughput

0.536

High

142045

ITAV
Integrin alpha-V

1

1

Small-scale

0.501

High

142063

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.494

High

142069

CNTRB
Centrobin

1

1

High-throughput

0.489

High

142049

ITB5
Integrin beta-5

1

0

Small-scale

0.480

High

142034

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

142035

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

142043

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.479

High

142046

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

142048

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

142059

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.479

High

142072

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

142051

1433S
14-3-3 protein sigma

1

0

Small-scale

0.458

High

142054

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

142060

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

142066

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

142067

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

142076

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

142033

INSI1
Insulin-induced gene 1 protein

1

2

High-throughput

0.437

High

142037

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.437

High

142041

LDLR
Low-density lipoprotein receptor

1

6

High-throughput

0.437

High

142058

RHOA
Transforming protein RhoA

1

5

High-throughput

0.437

High

142061

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.437

High

142055

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

142064

CASP8
Caspase-8

1

0

High-throughput

0.426

High

142042

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

142036

NSMA
Sphingomyelin phosphodiesterase 2

2

0

High-throughput

0.316

High

142074

UBQL2
Ubiquilin-2

2

0

High-throughput

0.316

High

142047

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.313

High

142038

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.269

Low

142039

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

142050

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.249

Low

142052

BASI
Basigin

1

0

High-throughput

0.249

Low

142056

RAB25
Ras-related protein Rab-25

1

0

High-throughput

0.249

Low

142065

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

142068

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

142070

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.249

Low

142071

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.249

Low

142073

ANLN
Anillin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025