Protein: DTL
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)

Gene: DTL
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q9NZJ0

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082431

DDB1
DNA damage-binding protein 1

13

14

Small-scale

0.981

High

1343544

KMT5A
N-lysine methyltransferase KMT5A

3

20

Small-scale

0.861

High

1043267

CUL4A
Cullin-4A

13

20

Small-scale

0.760

High

1043621

CUL4B
Cullin-4B

11

20

Small-scale

0.756

High

517505

PCNA
Proliferating cell nuclear antigen

7

1

Small-scale

0.749

High

1271459

KAT2A
Histone acetyltransferase KAT2A

1

19

Small-scale

0.724

High

758349

CDN1A
Cyclin-dependent kinase inhibitor 1

5

3

Small-scale

0.716

High

1272650

CSN5
COP9 signalosome complex subunit 5

5

6

Small-scale

0.709

High

1329452

PDCL3
Phosducin-like protein 3

1

4

High-throughput

0.691

High

1184997

CSN6
COP9 signalosome complex subunit 6

4

2

Small-scale

0.691

High

1328968

CDT1
DNA replication factor Cdt1

4

1

Small-scale

0.686

High

903563

WDR5
WD repeat-containing protein 5

1

19

Small-scale

0.665

High

387632

P53
Cellular tumor antigen p53

3

4

Small-scale

0.664

High

1314404

DDA1
DET1- and DDB1-associated protein 1

3

2

Small-scale

0.656

High

849464

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

9

Small-scale

0.647

High

896553

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

9

Small-scale

0.647

High

1038185

ATR
Serine/threonine-protein kinase ATR

1

8

Small-scale

0.647

High

1311908

CSN4
COP9 signalosome complex subunit 4

3

2

Small-scale

0.640

High

1069236

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

1233656

CARME
Carnosine N-methyltransferase

3

0

High-throughput

0.638

High

154253

CHK1
Serine/threonine-protein kinase Chk1

2

1

Small-scale

0.629

High

826921

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.628

High

1273411

GLMN
Glomulin

2

2

High-throughput

0.628

High

1306712

TCPH
T-complex protein 1 subunit eta

2

20

High-throughput

0.628

High

1349193

PFD2
Prefoldin subunit 2

2

4

High-throughput

0.628

High

1204477

FBX11
F-box only protein 11

2

2

Small-scale

0.624

High

910100

1433E
14-3-3 protein epsilon

2

3

Small-scale

0.620

High

211262

BUB3
Mitotic checkpoint protein BUB3

1

16

Small-scale

0.618

High

331893

NSD2
Histone-lysine N-methyltransferase NSD2

1

19

Small-scale

0.618

High

851896

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

9

Small-scale

0.618

High

896239

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.618

High

930422

UBC9
SUMO-conjugating enzyme UBC9

1

11

High-throughput

0.618

High

1254034

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

7

High-throughput

0.618

High

1265907

DDB2
DNA damage-binding protein 2

1

16

Small-scale

0.618

High

1282356

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

9

Small-scale

0.618

High

1297374

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

9

Small-scale

0.618

High

1024229

CSN1
COP9 signalosome complex subunit 1

2

7

Small-scale

0.611

High

1305354

CSN8
COP9 signalosome complex subunit 8

2

0

High-throughput

0.602

High

921449

RBX1
E3 ubiquitin-protein ligase RBX1

2

3

Small-scale

0.595

High

228922

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.584

High

684362

1433S
14-3-3 protein sigma

2

20

Small-scale

0.584

High

1061787

SHPRH
E3 ubiquitin-protein ligase SHPRH

2

17

Small-scale

0.584

High

1349194

CSN3
COP9 signalosome complex subunit 3

2

6

Small-scale

0.584

High

1309073

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

19

Small-scale

0.575

High

225069

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.574

High

1134442

KPRP
Keratinocyte proline-rich protein

2

3

High-throughput

0.558

High

1331480

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.553

High

1039494

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.537

High

243642

DNJA2
DnaJ homolog subfamily A member 2

1

12

High-throughput

0.536

High

596331

FILA
Filaggrin

1

2

High-throughput

0.536

High

821444

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

943519

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

1039183

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.536

High

1075468

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

2

High-throughput

0.536

High

1266431

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.536

High

1349195

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

772186

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.515

High

617223

LORI
Loricrin

1

0

High-throughput

0.513

High

787793

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

415088

CDK1
Cyclin-dependent kinase 1

1

7

Small-scale

0.501

High

625618

CDK2
Cyclin-dependent kinase 2

1

7

Small-scale

0.501

High

841401

TOB1
Protein Tob1

1

1

Small-scale

0.501

High

246052

PFD1
Prefoldin subunit 1

1

3

High-throughput

0.489

High

836340

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

1165495

SBSN
Suprabasin

1

1

High-throughput

0.489

High

1169030

DEFI8
Differentially expressed in FDCP 8 homolog

1

4

High-throughput

0.489

High

1218307

SPA12
Serpin A12

1

4

High-throughput

0.489

High

1261829

POF1B
Protein POF1B

1

1

High-throughput

0.489

High

1336539

DPOD4
DNA polymerase delta subunit 4

1

0

Small-scale

0.480

High

63529

ARGFX
Arginine-fifty homeobox

1

6

High-throughput

0.479

High

434042

LYN
Tyrosine-protein kinase Lyn

1

1

Small-scale

0.479

High

529814

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

573507

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.479

High

598354

FLNA
Filamin-A

1

12

High-throughput

0.479

High

640282

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

4

High-throughput

0.479

High

647330

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

683763

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.479

High

714443

HSP74
Heat shock 70 kDa protein 4

1

9

Small-scale

0.479

High

780224

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

794325

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.479

High

855568

MSH6
DNA mismatch repair protein Msh6

1

5

Small-scale

0.479

High

897319

CSN2
COP9 signalosome complex subunit 2

1

6

Small-scale

0.479

High

905191

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

927593

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

963002

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.479

High

982557

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

992972

SRSF1
Serine/arginine-rich splicing factor 1

1

19

High-throughput

0.479

High

1042699

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1055174

HLTF
Helicase-like transcription factor

1

10

Small-scale

0.479

High

1120023

PDCD4
Programmed cell death protein 4

1

2

Small-scale

0.479

High

1153524

SDE2
Splicing regulator SDE2

1

4

Small-scale

0.479

High

1292261

AURKB
Aurora kinase B

1

6

Small-scale

0.479

High

1296932

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1345440

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

Small-scale

0.479

High

1349192

CSN7A
COP9 signalosome complex subunit 7a

1

2

High-throughput

0.479

High

560422

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

590228

CCNA2
Cyclin-A2

1

0

Small-scale

0.458

High

1146200

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

1161845

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1245072

FBH1
F-box DNA helicase 1

1

0

Small-scale

0.458

High

1316780

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.437

High

179273

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

245851

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

1239479

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

1328675

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

1166012

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1349196

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024